A5071185748- Per- and polyfluoroalkyl substances research
- Toxic Organic Pollutants Impact
- Atmospheric chemistry and aerosols
- Effects and risks of endocrine disrupting chemicals
- Fluoride Effects and Removal
- Forensic Fingerprint Detection Methods
Oregon State University
2021-2024
Per- and polyfluoroalkyl substances (PFAS) are a class of widely used chemicals with limited human health effects data relative to the diversity structures manufactured. To help fill this gap, an extensive in vivo developmental toxicity screen was performed on 139 PFAS provided by US EPA. Dechorionated embryonic zebrafish were exposed 10 nominal water concentrations (0.015-100 µM) from 6 120 h post-fertilization (hpf). The embryos assayed for photomotor response (EPR), larval (LPR), 13...
Per- and polyfluoroalkyl substances (PFAS) are ubiquitously detected in the environment, some pose significant human environmental health concerns globally. While PFAS induce adverse effects, relatively few toxicological studies adequately address broad structural diversity of this chemical class. In current study, we evaluated 58 individual spanning 14 subclasses 2 mixtures at single concentrations for developmental toxicity zebrafish using highly sensitive behavior endpoints. Following...
This study elucidates per- and polyfluoroalkyl substance (PFAS) fingerprints for specific PFAS source types. Ninety-two samples were collected from aqueous film-forming foam impacted groundwater (AFFF-GW), landfill leachate, biosolids municipal wastewater treatment plant effluent (WWTP), the pulp paper power generation industries. High-resolution mass spectrometry operated with electrospray ionization in negative mode was used to quantify up 50 target PFASs screen semi-quantify 2,266 suspect...
Semiquantitation of suspect per- and polyfluoroalkyl substances (PFAS) in complex mixtures is challenging due to the increasing number PFAS. Traditional 1:1 matching strategies require selecting calibrants (target-surrogate standard pairs) based on head group, fluorinated chain length, retention time, which time-consuming requires expert knowledge. Lack uniformity calibrant selection for estimating concentrations among different laboratories makes comparing reported difficult. In this study,...
Ubiquitous anthropogenic contaminants of concern, per- and polyfluoroalkyl substances (PFAS) are frequently detected in the environment human populations around world. Diet is a predominate route exposure, PFAS measured food. Manufacturing trends have shifted from legacy to shorter-chain alternatives that suggested be safer, such as perfluorohexanoic acid (PFHxA). However, current amount data support safety assessments these not yet sufficient. The present study investigated effects 42-day...
The unpredictable biodegradation of fluorotelomer (FT)-based per- and polyfluoroalkyl substances (PFAS) causes complicated risk management PFAS-impacted sites. Here, we have successfully used redundancy analysis to link FT-based precursor key microbes genes soil microbiomes shaped by different classes carbon sources: alcohols (C2–C4), alkanes (C6 C8), an aromatic compound (phenol), or a hydrocarbon surfactant (cocamidopropyl betaine [CPB]). All the enrichments defluorinated (n:2 FtOH; n = 4,...