A5022798532- Salmonella and Campylobacter epidemiology
- Vibrio bacteria research studies
- interferon and immune responses
- Cancer Research and Treatments
- Cellular transport and secretion
- Macrophage Migration Inhibitory Factor
- Ubiquitin and proteasome pathways
- Immune cells in cancer
- Viral gastroenteritis research and epidemiology
- Toxoplasma gondii Research Studies
- Immunotherapy and Immune Responses
- Neutrophil, Myeloperoxidase and Oxidative Mechanisms
- Gut microbiota and health
- Pancreatic and Hepatic Oncology Research
- Bacteriophages and microbial interactions
- Cancer Cells and Metastasis
- Endoplasmic Reticulum Stress and Disease
- Autophagy in Disease and Therapy
- Trace Elements in Health
- Immune responses and vaccinations
- Adenosine and Purinergic Signaling
- Cholangiocarcinoma and Gallbladder Cancer Studies
Université Libre de Bruxelles
2023
Institut Jules Bordet
2023
Regional Centre for Biotechnology
2015-2021
Manipal Academy of Higher Education
2017-2021
Posttranslational modifications (PTMs) can alter many fundamental properties of a protein. One or combinations them have been known to regulate the dynamics cellular pathways and consequently all vital processes. Understandably, pathogens evolved sophisticated strategies subvert these mechanisms achieve instantaneous control over host functions. Here, we present first report modulation by intestinal pathogen Salmonella enterica serovar Typhimurium (S. Typhimurium) SUMOylation, PTM pathway...
Post-translational modification pathways such as SUMOylation are integral to all cellular processes and tissue homeostasis. We investigated the possible involvement of in epithelial signalling Crohn's disease (CD) ulcerative colitis (UC), two major forms inflammatory bowel (IBD). Initially a murine model IBD, induced by dextran-sulfate-sodium (DSS mice), we observed inflammation accompanied lowering global colonic epithelium. The alteration was due decrease sole SUMO E2 enzyme (Ubc9)....
Salmonella Typhimurium (ST) is an intracellular pathogen that causes gastroenteritis in humans. Aided by a battery of effector proteins, ST resides intracellularly specialized vesicle, called Salmonella-containing vacuole (SCV) utilizes the host endocytic vesicular-transport pathway (VTP). Here we probed possible role SUMOylation, post-translation modification pathway, SCV biology. Proteome analysis complex mass-spectrometry (MS/MS) revealed dramatically altered SUMO-proteome (SUMOylome)...
Non-typhoidal Salmonella (NTS) infections result in self limiting gastroenteritis except rare cases wherein manifestations of chronic can occur. Strategies employed by to thrive hostile environments host during are complex and multifaceted. In state, a coordinated action bacterial effectors allows reprogramming macrophages M2 subtype thereby creating permissible replicative niche. The mechanistic details these processes not fully known. the current study we identified, histone H3-lysine 27...
One of the mechanisms shaping pathophysiology during infection enteric pathogen Salmonella Typhimurium is host PTM machinery utilization by encoded effectors. ( S . Tm) in cells thrives a vacuolated compartment, containing vacuole (SCV), which sequentially acquires endosomal and lysosomal markers. Long tubular structures, called as induced filaments (SIFs), are further generated Tm, known to be required for SCV’s nutrient acquisition, membrane maintenance stability. A tightly coordinated...
Abstract Gastroenteritis causing pathogen Salmonella Typhimurium ( S. Tm) during its infection in host cells thrives a vacuolated compartment, Containing Vacuole (SCV), which sequentially acquires endosomal and lysosomal markers. Long tubular structures, called as induced filaments (SIFs), are known to be required for SCV’s nutrient acquisition, membrane maintenance stability. A tightly coordinated interactions involving prominent effector SifA various adapters PLEKHM1, PLEKHM2 Rab GTPases...