A5053326284- Organoboron and organosilicon chemistry
- Catalytic Cross-Coupling Reactions
- Asymmetric Synthesis and Catalysis
- Catalytic C–H Functionalization Methods
- Advanced Synthetic Organic Chemistry
Center for Research in Molecular Medicine and Chronic Diseases
2023-2024
Universidade de Santiago de Compostela
2023-2024
A catalytic asymmetric reaction between allenes, bis(pinacolato)diboron, and allylic gem-dichlorides is reported. The method involves the coupling of a catalytically generated allyl copper species with gem-dichloride provides chiral internal 1,5-dienes featuring (Z)-configured alkenyl boronate chloride units high levels chemo-, regio-, enantio-, diastereoselectivity. synthetic utility products demonstrated synthesis range optically active compounds. DFT calculations reveal key noncovalent...
A Cu/Pd-catalyzed borylative coupling of allenes with allyl carbonates is reported. Synergistic Cu/Pd catalysis enables a divergent selectivity compared to Cu and allows for the regio-, diastereo-, enantioselective formation synthetically versatile chiral borylated 1,5-dienes featuring two adjacent tertiary stereocenters. DFT calculations support closed inner-sphere S