A5054567062- Analytical Chemistry and Sensors
- 3D Printing in Biomedical Research
- Molecular Sensors and Ion Detection
- Photoreceptor and optogenetics research
- Electrochemical sensors and biosensors
- Photochemistry and Electron Transfer Studies
- Microfluidic and Capillary Electrophoresis Applications
- Mass Spectrometry Techniques and Applications
- Nanoplatforms for cancer theranostics
- Spectroscopy and Quantum Chemical Studies
- Innovative Microfluidic and Catalytic Techniques Innovation
- Cancer Cells and Metastasis
- Urologic and reproductive health conditions
- Cancer Genomics and Diagnostics
- Carbon and Quantum Dots Applications
- Analytical Chemistry and Chromatography
- Cancer, Hypoxia, and Metabolism
- Lipid Membrane Structure and Behavior
- Redox biology and oxidative stress
- Genital Health and Disease
- bioluminescence and chemiluminescence research
- Nanocluster Synthesis and Applications
- Urological Disorders and Treatments
- Nanopore and Nanochannel Transport Studies
- Medical Imaging Techniques and Applications
Istituto di Nanotecnologia
2020-2022
National Research Council
2021-2022
Institute of Nanotechnology
2020
Istituto Nanoscienze
2020
National Academies of Sciences, Engineering, and Medicine
2020
Vardhman Mahavir Medical College & Safdarjung Hospital
2018
Indian Institute of Technology Guwahati
2016-2017
We report 250–800 nm UV-Vis monomeric protein absorption originating from backbone–sidechain and sidechain–sidechain charge transfer transitions involving Lys/Glu residues.
The detection of extracellular pH at single cell resolution is challenging and requires advanced sensibility. Sensing high spatial temporal might provide crucial information in understanding the role its fluctuations a wide range physio-pathological cellular processes, including cancer. Here, method to embed silica-based fluorescent sensors into alginate-based three-dimensional (3D) microgels tumour models, coupled with computational for fine data analysis, presented. By means confocal laser...
Pyranine (HPTS) is a remarkably interesting pH-sensitive dye that has been used for plenty of applications. Its high quantum yield and extremely sensitive ratiometric fluorescence against pH change makes it very favorable pH-sensing applications the development nano-/microsensors. However, its strong negative charge lack easily modifiable functional groups difficult to use with charged substrates such as silica. This study reports methodology noncovalent HPTS immobilization on silica...
pH balance and regulation within organelles are fundamental to cell homeostasis proliferation. The ability track in cells becomes significantly important understand these processes detail. Fluorescent sensors based on micro- nanoparticles have been applied measure intracellular pH; however, an accurate methodology precisely monitor acidification kinetics of living has not established, limiting the scope this class sensors. Here, silica-based fluorescent microparticles were utilized probe...
The homeostatic control of their environment is an essential task living cells. It has been hypothesized that, when microenvironmental pH inhomogeneities are induced by high cellular metabolic activity, diffusing protons act as signaling molecules, driving the establishment exchange networks sustained cell-to-cell shuttling overflow products such lactate. Despite fundamental role, extent and dynamics largely unknown due to lack methods in single-cell flux analysis. In this study, we provide...
Abstract Invited for the cover of this issue are Anil Chandra, Loretta L. del Mercato and co‐workers at Institute Nanotechnology National Research Council University Salento. The image depicts how negatively charged pH‐sensitive pyranine (HPTS) molecules were successfully immobilized on silica microparticles (SMPs) without compromising molecules′ pH sensitivity. These resulting sensors can be used to measure in vitro vivo due cytocompatibility HPTS SMPs. Read full text article...
Acrochordon commonly known as skin tag is a benign mesenchymal lesion which appears on keratinized surface of folds.Most them are 2 to 5 mm in dimension.Females have greater predilection for the vulvovaginal region compared with cervix.The diagnosis may be misunderstood being malignant due its clinical picture and hence, histopathology report necessary confirmation.This case reports rarest kind regard size measuring 55 × 10 20 cm.Thus, it becomes largest acrochordon reported till date.
Abstract While 3D cell cultures have been used as suitable representatives of in vivo conditions compared to 2D systems, scalability and flexibility designing such platforms has a major challenge1. Micron-sized culture offer the possibility high throughput analysis, however challenges exist with respect their overall design. Technical obstacles include difficulties supporting multiple types (e.g. co-cultures cancer associated fibroblasts (CAFs) tumor cells) well enabling monitoring important...
Abstract Pancreatic ductal adenocarcinoma (PDAC) is known to be one of the deadliest cancers due its late diagnosis and faster metastasis rate1. Thus, time required test patient-derived cancer cells against different therapeutics becomes extremely crucial. Gene expression analysis using real-time PCR vital, typically when designing patient-specific therapeutics. 2D tumor models do not represent true picture in vivo. In order perform these gene studies, robust 3D are required2. The...
Abstract The homeostatic control of their environment is an essential task living cells. It has been hypothesized that when microenvironmental pH inhomogeneities are induced by high cellular metabolic activity, diffusing protons act as signaling molecules, driving the establishment cross-feeding networks sustained cell-to-cell shuttling overflow products such lactate. Despite fundamental role, extent and dynamics largely unknown due to lack methods in single cell flux analysis. In this study...