A5071865916- Experimental Learning in Engineering
- Dynamics and Control of Mechanical Systems
- Tuberculosis Research and Epidemiology
- Engineering Education and Pedagogy
- Modeling and Simulation Systems
- Robotic Mechanisms and Dynamics
- Mycobacterium research and diagnosis
- Photovoltaic System Optimization Techniques
- Mechatronics Education and Applications
- Immune cells in cancer
- Advanced Battery Technologies Research
- Simulation Techniques and Applications
- Immunotherapy and Immune Responses
- Immunodeficiency and Autoimmune Disorders
- Advanced Control Systems Optimization
- Iterative Learning Control Systems
- Neonatal Respiratory Health Research
- Vehicle Dynamics and Control Systems
- Pneumocystis jirovecii pneumonia detection and treatment
- Smart Grid Energy Management
- Solar Radiation and Photovoltaics
- Industrial Automation and Control Systems
- Insect Resistance and Genetics
- Energy Harvesting in Wireless Networks
- Electric Vehicles and Infrastructure
University of Klagenfurt
2024
FH Kärnten
2024
Northern Illinois University
2015-2024
Texas Biomedical Research Institute
2017-2024
Laurentian University
2024
BRAC University
2013-2022
University of Leeds
2020
Cochin University of Science and Technology
2020
University of Illinois Chicago
2020
Andhra University
2020
Mycobacterium tuberculosis (M.tb) survives in macrophages part by limiting phagosome–lysosome (P-L) fusion. M.tb mannose-capped lipoarabinomannan (ManLAM) blocks phagosome maturation. The pattern recognition mannose receptor (MR) binds to the ManLAM caps and mediates phagocytosis of bacilli human macrophages. Using quantitative electron confocal microscopy, we report that engagement MR during phagocytic process is a key step P-L fusion microspheres was significantly reduced an MR-expressing...
Pseudomonas aeruginosa causes chronic lung infections in the airways of cystic fibrosis (CF) patients. Psl is an extracellular polysaccharide expressed by non-mucoid P. strains, which are believed to be initial colonizers. We hypothesized that protects from host defences within CF prior their conversion mucoid phenotype. discovered serum opsonization significantly increased production reactive oxygen species (ROS) neutrophils exposed a psl-deficient mutant, compared with wild-type (WT) and...
Abstract Mycobacterium tuberculosis enhances its survival in macrophages by suppressing immune responses part through complex cell wall structures. Peroxisome proliferator-activated receptor γ (PPARγ), a nuclear superfamily member, is transcriptional factor that regulates inflammation and has high expression alternatively activated alveolar macrophage-derived foam cells, both types relevant to pathogenesis. In this study, we show virulent M. mannose-capped lipoarabinomannan induce PPARγ...
The macrophage mannose receptor (MR, CD206) is a C-type lectin expressed predominantly by most tissue macrophages, dendritic cells and specific lymphatic or endothelial cells. It functions in endocytosis phagocytosis, plays an important role immune homeostasis scavenging unwanted mannoglycoproteins. More attention being paid to its particularly high expression pathology sites during disease such the tumor microenvironment. MR recognizes variety of microorganisms their mannan-coated cell...
Abstract The Mycobacterium tuberculosis (M.tb) envelope is highly mannosylated with phosphatidyl-myo-inositol mannosides (PIMs), lipomannan, and mannose-capped lipoarabinomannan (ManLAM). Little known regarding the interaction between specific PIM types host cell C-type lectin pattern recognition receptors. macrophage mannose receptor (MR) dendritic cell-specific ICAM-3-grabbing nonintegrin on cells engage ManLAM caps regulate several responses. In this study, we analyzed association of...
Abstract The pulmonary innate immune system responds to various airborne microbes. Although its specificity is broad and based on the recognition of pathogen-associated molecular patterns, it uniquely regulated limit inflammation thereby prevent damage gas-exchanging alveoli. Macrophages, critical cell determinants this system, recognize microbes through pattern receptors such as TLRs, which typically mediate proinflammatory responses. lung collectin, surfactant protein A (SP-A), has emerged...
Summary Mycobacterium tuberculosis (M.tb), which causes tuberculosis, is a host-adapted intracellular pathogen of macrophages. Intracellular pattern recognition receptors in macrophages such as nucleotide-binding oligomerization domain (NOD) proteins regulate pro-inflammatory cytokine production. NOD2-mediated signalling pathways response to M.tb have been studied primarily mouse models and cell lines but not primary human Thus we sought determine the role NOD2 regulating production growth...
Granulomas sit at the center of tuberculosis (TB) immunopathogenesis. Progress in biomarkers and treatment specific to human granuloma environment is hindered by lack a relevant tractable infection model that better accounts for complexity host immune response as well pathogen counterresponses subvert immunity granulomas. Here we developed characterized an vitro derived from peripheral blood mononuclear cells (PBMCs) autologous serum. Importantly, interrogated this its ability discriminate...
ABSTRACT Mycobacterium abscessus has emerged as an important pathogen in people with chronic inflammatory lung diseases such cystic fibrosis, and recent reports suggest that it may be transmissible by fomites. M. exhibits two major colony morphology variants: a smooth morphotype ( Ma Sm ) rough Rg ). Biofilm formation, prolonged intracellular survival, variant diversity can each contribute to the persistence of other bacterial pathogens pulmonary diseases. A prevailing paradigm infection is...
The purpose of this article is to provide information on the history, accomplishments, and future direction Bt brinjal (eggplant) program in Bangladesh, formerly under Agricultural Biotechnology Support Project II, now South Asia Eggplant Improvement Partnership (SAEIP). India-based Maharashtra Hybrid Seed Company (Mahyco) developed an eggplant expressing Cry1Ac (EE-1) for control fruit shoot borer (EFSB). In a partnership among Mahyco, USAID, Sathguru Management Consultants Cornell...
Surface-exposed unusual lipids containing phthiocerol and phenolphthiocerol are found only in the cell wall of slow-growing pathogenic mycobacteria thought to play important roles host-pathogen interaction. The enzymology molecular genetics biosynthesis unknown. We postulate domain organization a set multifunctional enzymes cluster genes (pps) that would encode these for phenolphthiocerol. A cosmid postulated ppsgene was identified by screening genomic library ofMycobacterium bovis BCG with...
γ-Tilmanocept ((99m)Tc-labeled-tilmanocept or [(99m)Tc]-tilmanocept) is the first mannose-containing, receptor-directed, radiolabeled tracer for highly sensitive imaging of sentinel lymph nodes in solid tumor staging. To elucidate mannose-binding receptor that retains tilmanocept this microenvironment, human macrophages were used have high expression C-type lectin mannose (MR; CD206). Cy3-labeled exhibited specificity binding to was nearly abolished competitive inhibition experiments....
Peroxisome proliferator-activated receptor (PPAR)γ is a global transcriptional regulator associated with anti-inflammatory actions. It highly expressed in alveolar macrophages (AMs), which are unable to clear the intracellular pathogen Mycobacterium tuberculosis (M.tb). Although M.tb infection induces PPARγ human macrophages, contributes growth, mechanisms underlying this largely unknown. We undertook NanoString gene expression analysis identify novel effectors that condition be more...
As we age, there is an increased risk for the development of tuberculosis (TB) caused by Mycobacterium (Mtb) infection. Few studies consider that age-associated changes in alveolar lining fluid (ALF) may increase susceptibility altering soluble mediators innate immunity. We assessed impact adult or elderly human ALF during Mtb infection vitro and vivo. identified amplification pro-oxidative proinflammatory pathways decreased binding capability surfactant-associated surfactant protein A...
Lead halide perovskites have distinct physiochemical properties and demonstrate remarkable power conversion efficiency. We used density functional theory to investigate the electrical, optical, structural, elastic features of non-toxic InGeCl3 InGeBr3 perovskite compounds at different hydrostatic pressures, from 0 8 GPa. exhibit noteworthy changes in their electronic optical under pressure conditions. When is GPa, direct bandgap for 0.886 eV, it 0.536 eV. This gap decreases as rises....
ABSTRACT Lung surfactant protein D (SP-D) binds to Mycobacterium tuberculosis surface lipoarabinomannan and results in bacterial agglutination, reduced uptake, inhibition of growth human macrophages. Here we show that SP-D limits the intracellular bacilli macrophages by increasing phagosome-lysosome fusion but not generating a respiratory burst.
ABSTRACT The ability of pathogenic mycobacteria to block phagosome-lysosome fusion is critical for its pathogenesis. molecules expressed by that inhibit phagosome maturation and the mechanism this inhibition have been extensively studied. Recent work has indicated mannosylated lipoarabinomannan (ManLAM) isolated from Mycobacterium tuberculosis can function delay requires interaction ManLAM with mannose receptor (MR). However, other not well described. In present study, we show phagosomes...