A5019976583- Cancer Immunotherapy and Biomarkers
- Radiomics and Machine Learning in Medical Imaging
- Colorectal and Anal Carcinomas
- Inflammatory Biomarkers in Disease Prognosis
- Esophageal Cancer Research and Treatment
- Multiple and Secondary Primary Cancers
- Lung Cancer Research Studies
- Bladder and Urothelial Cancer Treatments
- Cancer Genomics and Diagnostics
- Immune Cell Function and Interaction
- Pancreatic and Hepatic Oncology Research
- Colorectal Cancer Treatments and Studies
- Microbial bioremediation and biosurfactants
- Lymphoma Diagnosis and Treatment
- Adipokines, Inflammation, and Metabolic Diseases
- Biochemical and biochemical processes
- Metal-Catalyzed Oxygenation Mechanisms
- Ferroptosis and cancer prognosis
- Lung Cancer Treatments and Mutations
- Genetic factors in colorectal cancer
- Immunotherapy and Immune Responses
- Neutrophil, Myeloperoxidase and Oxidative Mechanisms
- Adipose Tissue and Metabolism
- Drug Transport and Resistance Mechanisms
- Health Systems, Economic Evaluations, Quality of Life
University of Michigan
2007-2020
University of Iowa
2006-2018
Obesity produces a chronic inflammatory state involving the NFκB pathway, resulting in persistent elevation of noncanonical IκB kinases IKKε and TBK1. In this study, we report that these attenuate β-adrenergic signaling white adipose tissue. Treatment 3T3-L1 adipocytes with specific inhibitors restored lipolysis attenuated by TNFα Poly (I:C). Conversely, overexpression reduced induction Ucp1, lipolysis, cAMP levels, phosphorylation hormone sensitive lipase response to isoproterenol or...
ABSTRACT Rieske oxygenase (RO) systems are two- and three-component enzyme that catalyze the formation of cis -dihydrodiols from aromatic substrates. Degradation pollutants in contaminated soil generation chiral synthons have been major foci RO research. Substrate specificity product regio- stereoselectivity shown to vary between individual ROs. While directed evolution methods for altering function successful past, rational engineering these enzymes still poses a challenge due lack...
Curacin A is a mixed polyketide/nonribosomal peptide possessing anti-mitotic and anti-proliferative activity. In the biosynthesis of curacin A, N-terminal domain CurF multifunctional protein catalyzes decarboxylation 3-methylglutaconyl-acyl carrier (ACP) to 3-methylcrotonyl-ACP, postulated precursor cyclopropane ring A. This decarboxylase encoded within an “HCS cassette” that used by several other polyketide biosynthetic systems generate chemical diversity introduction β-branch functional...
Abstract Ipilimumab, nivolumab, and pembrolizumab represent a new class of immunotherapeutic drugs for treating patients with advanced cancer. Known as checkpoint inhibitors, these act to upregulate the cellular humoral immune response tumor antigens by inhibiting T-cell autoregulation. As consequence, they can be associated immune-related adverse events (irAEs) due loss self-tolerance, including rare cases cytopenias. We performed retrospective clinical chart review, serologic, hematology,...
Aims Distinguishing true oesophageal Candida infections from oral contaminants is a common diagnostic issue. Historically, histological features believed to indicate infection included epithelial invasion by pseudohyphae and intraepithelial neutrophils. Whether or not these correlate with endoscopic lesions, symptoms response therapy has never been tested in large cohort. The aim of this study was determine whether specific clinical findings when found biopsies. Methods results We reviewed...
Immunotherapy response score (IRS) integrates tumor mutation burden (TMB) and quantitative expression biomarkers to predict anti-PD-1/PD-L1 [PD-(L)1] monotherapy benefit. Here, we evaluated IRS in additional cohorts. Patients from an observational trial (NCT03061305) treated with anti-PD-(L)1 were included assigned IRS-High (-H) versus -Low (-L) groups. Associations real-world progression-free survival (rwPFS) overall (OS) determined by Cox proportional hazards (CPH) modeling. Those...
467 Background: Angiogenesis inhibitors, including vascular endothelial growth factor receptor (VEGFR) tyrosine kinase inhibitors (TKIs), are standard of care therapy (alone and in combination) for several advanced cancers, RCC. There is an unmet need a biomarker to identify patients with RCC most likely benefit from VEGFR TKIs guide individualized treatment decision making. Hence, we sought develop validate predicting single-agent systemic TKI Methods: Candidate biomarkers were selected by...
Abstract Background: Antibody-drug conjugates (ADCs), including trastuzumab deruxtecan (T-DXd; targeting HER2) and sacituzumab govitecan (SG; TROP2), have transformed the management of metastatic breast cancer, with additional ADCs approved in other solid tumors or late-stage development. To date, expression ADC target alone has been poorly predictive objective response rates (ORRs) both cancer tumors. Hence, there is an urgent need to develop better biomarkers guide vs. treatments, T-DXd SG...
<p>Supplementary Figure S8. shows overlap weighting propensity score analysis of the chemotherapy, anti-PD-(L)1, and chemotherapy + anti-PD-(L)1 validation cohort</p>
<p>Supplementary Data S1 shows the REMARK checklist for study</p>
<p>Supplementary Figure S5 shows robustness of Immunotherapy Response Score to self-reported race</p>