A5083272314- Bacterial Genetics and Biotechnology
- SARS-CoV-2 and COVID-19 Research
- Viral Infections and Immunology Research
- Viral gastroenteritis research and epidemiology
- Bacteriophages and microbial interactions
- Glycosylation and Glycoproteins Research
- Microbial bioremediation and biosurfactants
- Microtubule and mitosis dynamics
- Mitochondrial Function and Pathology
- Microbial Metabolic Engineering and Bioproduction
- Biochemical and Molecular Research
- Photosynthetic Processes and Mechanisms
ETH Zurich
2020
Imperial College London
2019
Plants, algae, and cyanobacteria fix carbon dioxide to organic with the Calvin–Benson (CB) cycle. Phosphoribulokinase (PRK) glyceraldehyde 3-phosphate dehydrogenase (GAPDH) are essential CB-cycle enzymes that control substrate availability for carboxylation enzyme Rubisco. PRK consumes ATP produce Rubisco ribulose bisphosphate (RuBP). GAPDH catalyzes reduction step of CB cycle NADPH sugar (GAP), which is used regeneration RuBP main exit point coregulated by redox state a conditionally...
Abstract The non-structural protein 1 (Nsp1), also referred to as the host shutoff factor, is first viral that synthesized in SARS-CoV-2 infected human cells suppress innate immune functions 1,2 . By combining cryo-electron microscopy and biochemical experiments, we show Nsp1 binds 40S subunit ribosomal complexes including 43S pre-initiation complex. inserts its C-terminal domain at entrance mRNA channel where it interferes with binding. We observe potent translation inhibition presence of...
An amendment to this paper has been published and can be accessed via a link at the top of paper.
FimA is the main structural subunit of adhesive type 1 pili from uropathogenic Escherichia coli strains. Up to 3000 copies assemble helical pilus rod through a mechanism termed donor strand complementation, in which incomplete immunoglobulin-like fold each complemented by N-terminal extension (Nte) next subunit. The Nte FimA, exhibits pseudo-palindromic sequence, inserted an antiparallel orientation relative last β-strand preceding pilus. resulting subunit-subunit interactions are...