A5035724219- Agriculture Sustainability and Environmental Impact
- Bone health and treatments
- Sustainable Agricultural Systems Analysis
- Agricultural Economics and Policy
- Radiopharmaceutical Chemistry and Applications
- Insect-Plant Interactions and Control
- Ovarian cancer diagnosis and treatment
- Pesticide Residue Analysis and Safety
- Medical Imaging and Pathology Studies
- Greenhouse Technology and Climate Control
- Land Use and Ecosystem Services
- Mycorrhizal Fungi and Plant Interactions
- Pesticide and Herbicide Environmental Studies
- Soil Carbon and Nitrogen Dynamics
- Environmental Impact and Sustainability
- Angiogenesis and VEGF in Cancer
- Climate change impacts on agriculture
- Insect and Pesticide Research
- Nitrogen and Sulfur Effects on Brassica
- Organic Food and Agriculture
- PI3K/AKT/mTOR signaling in cancer
- Insect Pest Control Strategies
- Multiple Myeloma Research and Treatments
- Agriculture and Rural Development Research
- Cancer Diagnosis and Treatment
Syngenta (United Kingdom)
2024
University of Hertfordshire
2013-2022
And Technology Research (United Kingdom)
2022
Amgen (United States)
2012-2018
Ibero American University
2018
Austrian Breast & Colorectal Cancer Study Group
2016
Medical University of Vienna
2016
Medical University of Graz
2016
AC Camargo Hospital
2016
The Royal Melbourne Hospital
2016
Despite a changing world in terms of data sharing, availability, and transparency, there are still major resource issues associated with collating datasets that will satisfy the requirements comprehensive pesticide risk assessments, especially those undertaken at regional or national scale. In 1996, long-term project was initiated to begin formatting eventually create free-to-all repository would provide transparent, harmonized, managed extensive dataset for all types assessments. Over last...
Trebananib, an investigational recombinant peptide-Fc fusion protein, neutralizes the receptor-ligand interaction between Tie2 and angiopoietin-1/2. This phase II study was conducted to evaluate trebananib plus sunitinib, a vascular endothelial growth factor receptor inhibitor, in patients with metastatic clear cell renal carcinoma.Adults carcinoma were enrolled sequentially onto two cohorts that received sunitinib 50 mg once per day for 4 weeks on 2 off intravenous week at dose of 10 mg/kg...
Arbuscular Mycorrhizal (AM) fungi form mutualistic symbiotic relationships with approximately 80% of terrestrial plant species, while producing the glycoprotein glomalin as a structural support molecule along their mycelial network. Glomalin confers two benefits for soils: (1) acting carbon and nitrogen storage molecule; (2) binding soil microaggregates (<250 µm) to larger, more stable structures. The present study aimed test hypothesis that correlation between aggregation exists this is...
Abstract Purpose: Bone antiresorptive agents can significantly reduce bone turnover markers (BTM) in patients with advanced cancer. We evaluated association of changes BTMs overall survival (OS), disease progression (DP), and (DPB) cancer metastases following denosumab or zoledronic acid treatment. Experimental Design: This is an integrated analysis patient-level data from three identically designed, blinded, phase III trials randomized to subcutaneous intravenous acid. Levels the urinary...
1080 Background: Zotatifin (eFT226) is a first-in-class, potent and sequence selective inhibitor of RNA helicase eIF4A that promotes stable mRNA:eIF4A:drug ternary complex at specific polypurine motifs within the 5’-UTR, preventing translation select transcripts. In preclinical models zotatifin treatment simultaneously down-regulated numerous oncogenes including CDK4, ERα, ERBB2, KRAS, CCND1. Methods: Following 3+3 dose escalation portion protocol (Part 1), Part 2 Simon’s two-stage design...
ABSTRACT Objective : To evaluate the utility of a modified calculation alveolar dead space fraction (Vd/Vt), combined with plasma D‐dimers, to aid in exclusion acute pulmonary embolism (PE). Methods A prospective comparison screening modalities was performed metropolitan teaching ED. Ambulatory patients evaluated for PE underwent simultaneous end‐tidal CO 2 and arterial blood gas determinations, as well venous latex‐agglutination D‐dimer quantification. The Bohr equation used calculate Vd/Vt...
Abstract Background: Adjuvant endocrine therapy compromises bone health in pre- and postmenopausal breast cancer (BC) patients. Bisphosphonates have been shown to prevent counteract these side effects of therapy, improve disease-free overall survival outcomes (natural or induced) BC patients (EBCTCG meta-analysis, Lancet 2015). The aim ABCSG-18 was investigate the adjuvant anti-RANK-ligand Denosumab on disease with early hormone receptor+ (HR+) receiving AI treatment. Patients Methods: 3,425...
<title>Abstract</title> We assembled a European bread wheat (Triticum aestivum L.) association mapping panel (n=480) genotyped using 90,000 single nucleotide polymorphism array, with the aim of identifying genetic loci controlling resistance to four fungal diseases: yellow (stripe) rust (YR), brown (leaf) (BR), Septoria tritici blotch (ST) and powdery mildew (PM). Simulations showed our have good power detect loci, >50% probability as little 5% variance when heritability was 0.6 or more....
Zero till cropping systems typically apply broad-spectrum herbicides such as glyphosate an alternative weed control strategy to the physical inversion of soil provided by cultivation. Glyphosate targets 5-enolpyruvylshikimate-3-phosphate (EPSP) synthase in plants. There is growing evidence that this may have a detrimental impact on non-target organisms those present microbiome. Species commercial importance, arbuscular mycorrhizal (AM) fungi form symbiotic relationship with plant roots are...
Arbuscular mycorrhizal (AM) fungi are one of the most common fungal organisms to exist in symbiosis with terrestrial plants, facilitating growth and maintenance arable crops. Wheat has been studied extensively for AM using carcinogen trypan blue as identifying stain components, namely arbuscles, vesicles hyphal structures. The present study uses Sheaffer ink a lower risk an alternative this carcinogenic stain. Justification is determined by stained wheat root sections ( n =120),...
Abstract The within‐field spatio‐temporal distributions and relationships of two pest insects with stem‐mining larvae, Psylliodes chrysocephala (L.) (Coleoptera: Chrysomelidae) Ceutorhynchus pallidactylus (Marsham) Curculionidae), their larval endoparasitoids, Tersilochus microgaster (Szépligeti) obscurator Aubert (Hymenoptera: Ichneumonidae), respectively, were studied in a crop winter oilseed rape [ Brassica napus L. (Brassicaceae)]. sampled, at different life stages, 40 spatially...
Ecological focus areas are one of three greening measures that were introduced into the European Common Agricultural Policy by reform in 2014, with aim enhancing ecological function agricultural landscapes. However, there concerns they will provide little or no additional benefit (enhanced biodiversity and ecosystem services) as those declared may already exist and/or any new be implemented on basis farm management burdens rather than criteria, such which easiest least costly to implement....
Abstract The majority of human breast cancers are dependent on hormone-stimulated estrogen receptor alpha (ER) and sensitive to its inhibition. Treatment resistance arises in most advanced due genetic alterations that promote ligand independent activation ER itself or target genes. Whereas re-targeting the binding domain (LBD) with newer antagonists can work some cases, these drugs largely ineffective many backgrounds including fusions lose LBD hyperactivate targets. By identifying mechanism...
The brassica pod midge (Dasineura brassicae) is an important and widespread pest of winter spring oilseed rape throughout Europe. Pods infested by D brassicae larvae split prematurely, releasing seeds, the drop to soil into which they burrow pupate. At this stage in its lifecycle potentially vulnerable predation carabid beetles foraging on surface. This first study UK focus as predators crop. spatio-temporal distributions dropping from crop canopy adult active surface were analysed two...
SUMMARY Reducing greenhouse gas emissions and optimizing energy consumption are important for mitigating climate change improving resource use efficiency. Strawberry ( Fragaria xananassa Duch) crops a key component of the UK soft fruit sector potentially resource-intensive crops. This is first study to undertake detailed environmental impact assessment all methods strawberry production. A total 14 systems with six additional sub-systems grown between 1 3 years were identified. They defined...