A5100413829- Neuroscience and Neuropharmacology Research
- Alzheimer's disease research and treatments
- Neuroinflammation and Neurodegeneration Mechanisms
- Medicinal Plants and Neuroprotection
- Cholinesterase and Neurodegenerative Diseases
- Neurogenesis and neuroplasticity mechanisms
- Tryptophan and brain disorders
- Memory and Neural Mechanisms
- Traditional Chinese Medicine Analysis
- Phytochemistry and Biological Activities
- Natural product bioactivities and synthesis
- Neurological Disease Mechanisms and Treatments
- Ziziphus Jujuba Studies and Applications
- Receptor Mechanisms and Signaling
- Stress Responses and Cortisol
- GABA and Rice Research
- Nerve injury and regeneration
- Flavonoids in Medical Research
- Neuroendocrine regulation and behavior
- Inflammatory mediators and NSAID effects
- Biochemical effects in animals
- Traditional Chinese Medicine Studies
- Aquaculture disease management and microbiota
- Phosphodiesterase function and regulation
- Biological and pharmacological studies of plants
Konkuk University
2021-2024
Ajou University
2024
Dong-A University
2014-2023
Medipost (South Korea)
2018
University of Bristol
2012-2018
Convergence
2017
Kyung Hee University
2007-2014
Oriental University
2009
Yonsei University
2003
Adult hippocampal neurogenesis is important in mediating hippocampal-dependent learning and memory. Exogenous ghrelin known to stimulate progenitor cell proliferation the dentate gyrus of adult hippocampus. The aim this study was investigate role endogenous regulating vivo differentiation newly generating cells hippocampus using knockout (GKO) mice. Targeted deletion gene resulted reduced numbers subgranular zone (SGZ) hippocampus, while treatment restored those wild-type controls. We also...
Alzheimer's disease (AD) is an incurable neurodegenerative characterised clinically by learning and memory impairments. Amyloid beta (Aβ) peptide-induced synaptic dysfunction a pathological process associated with early-stage AD. Here, we show that paracrine action of human umbilical cord blood-derived-mesenchymal stem cells (hUCB-MSCs) protects the hippocampus from synaptic-density loss in vitro vivo AD models. To identify factors underlying this rescue effect, analysed hUCB-MSCs' secretome...
Amyloid beta (Aβ) peptide, one of the most important pathogenic traits Alzheimer’s disease (AD), invokes a cascade oxidative damage and eventually leads to neuronal death. In present study, baicalein, wogonin, oroxylin A, main active flavones in Scutellaria baicalensis, were evaluated for their neuroprotective effects against Aβ25–35-stimulated damage. All tested compounds decreased Aβ25–35-induced ROS generation cell cycle arrest. particular, baicalein exhibited strongest antioxidant...
The G-protein coupled receptor family of glutamate receptors, termed metabotropic receptors (mGluRs), are implicated in numerous cellular mechanisms ranging from neural development to the processing cognitive, sensory, and motor information. Over last decade, multiple mGluR-related signal cascades have been identified at excitatory synapses, indicating their potential roles various forms synaptic function dysfunction. This review highlights recent studies investigating mGluR5, a subtype...
One of the major neurodegenerative features Alzheimer's disease (AD) is presence neurotoxic amyloid plaques composed beta peptide (Aβ). β-Secretase (BACE1) and acetylcholinesterase (AChE), which promote Aβ fibril formation, have become attractive therapeutic targets for AD. P-glycoprotein (P-gp), efflux pump blood-brain barrier (BBB), plays a critical role in limiting molecules. In pursuit discovering natural anti-AD candidate, bioactivity, physicochemical, drug-likeness, molecular docking...
The intracellular signalling kinase, extracellular signal-regulated kinase 1/2 (ERK1/2) is required for new memory formation, suggesting that control of ERK might be a target the treatment cognitive dysfunction. Previously, we reported tanshinone congeners have ameliorating effects on drug-induced impairment in mice. Here, investigated possible modes action I learning and memory, associated with phosphorylation.Using immunohistochemical, Western blot techniques, behavioural testing, studied...
Mouse models of Alzheimer's disease (AD) have been developed to study the pathophysiology amyloid β protein (Aβ) toxicity, which is thought cause severe clinical symptoms such as memory impairment in AD patients. However, inconsistencies exist between studies using these animal models, specifically terms effects on synaptic plasticity, a major cellular model learning and memory. Whereas some find impairments plasticity others do not. We show that long-term potentiation (LTP), CA1 region...