A5012639732- Nonmelanoma Skin Cancer Studies
- Hedgehog Signaling Pathway Studies
- Ophthalmology and Eye Disorders
- Botulinum Toxin and Related Neurological Disorders
- Cutaneous Melanoma Detection and Management
- Cancer and Skin Lesions
- Facial Rejuvenation and Surgery Techniques
- Nasolacrimal Duct Obstruction Treatments
- Neurological disorders and treatments
- Ocular Oncology and Treatments
- Facial Nerve Paralysis Treatment and Research
- Ocular Surface and Contact Lens
- Glaucoma and retinal disorders
- Cardiac tumors and thrombi
- Neurosurgical Procedures and Complications
- Intracerebral and Subarachnoid Hemorrhage Research
- Dermatologic Treatments and Research
- melanin and skin pigmentation
- Genetic and rare skin diseases.
- Optical Coherence Tomography Applications
- Gastrointestinal Tumor Research and Treatment
- Cerebral Venous Sinus Thrombosis
- Genetics and Neurodevelopmental Disorders
- Genetic and Clinical Aspects of Sex Determination and Chromosomal Abnormalities
- Hair Growth and Disorders
Queen Victoria Hospital
2011-2023
King's College Hospital NHS Foundation Trust
2021-2023
Queen Mary University of London
2018-2021
King's College Hospital
2020
Queen Victoria Hospital NHS Foundation Trust
2020
Moorfields Eye Hospital
2011-2018
Queen Victoria Hospital
2018
University College London
2011-2018
Charing Cross Hospital
2012
Chelsea and Westminster Hospital
2009
Platinum chains are thinner than gold weights (GWs) and may confer a better eyelid curvature profile with reduced visibility. Outcomes compared measurements, cosmesis, complications.Forty-two primary GW 17 platinum chain insertions were identified subsequently matched for laterality, pathology, weight of implant. Twenty-two patients randomly allocated into 2 groups comparison; those receiving (n = 11) or to formulate retrospective case-controlled study. Primary upper loading surgery both...
<h3>Background</h3> Gold weights are effective for upper eyelid loading in patients with lagophthalmos. Complications include poor cosmesis, migration, extrusion, allergy and astigmatism. The authors looked at indications revision of primary gold inserted using a high pretarsal placement outcomes following correction. <h3>Methods</h3> A retrospective review 107 consecutive weight implants 95 lagophthalmos single centre over 5-year period. Implant utilised combined placement, levator...
The CRB1 gene plays a role in retinal development and its maintenance. When disrupted, it gives range of phenotypes such as early-onset severe dystrophy/Leber congenital amaurosis (EOSRD/LCA), retinitis pigmentosa (RP), cone-rod dystrophy (CORD) macular (MD). Studies retinopathies have shown thickening coarse lamination layers resembling an immature retina. Its foveal has not yet been described; however, this retrospective study is the first to report hypoplasia (FH) presence CRB1-related...
Sebaceous gland carcinoma (SGC) is a rare, but life-threatening condition with predilection for the periocular region. Eyelid SGC can be broadly categorised into two subtypes, namely either nodular or pagetoid latter being more aggressive and requiring radical excision to save life. We have identified key altered microRNAs (miRNA) involved in shared by both hsa-miR-34a-5p hsa-miR-16-5p. However, their gene targets BCL2 MYC were differentially expressed overexpressed unchanged suggesting...
Sebaceous carcinoma (SC) is a clinical masquerader of benign conditions resulting in significant eye morbidity, sometimes leading to extensive surgical treatment including exenteration, and even mortality. Little known about the genetic or molecular basis SC. This study identifies involvement Hedgehog (Hh) signaling periocular Fifteen patients with SC were compared 15 eyelid nodular basal cell (nBCC; Hh tumor), alongside four normal individuals as control for physiological expression....
Purpose: To report the occurrence of dry eye after Lester Jones tube (LJT) insertion. Methods: Retrospective case series from a single unit. The dacrocystorhinostomy (DCR) was carried out using both endoscopic and external approachs; however, insertion LJT used same method as either primary or secondary procedure. Dry an outcome measure only confirmed three separate visits presence patient symptoms signs with none preceding Results: Fifty-four patients underwent consecutive over 5-year...
obstruction.Multiple strictures (2-25) are often present, with frequent relapse following resection.Steroid responsiveness is typical but steroid dependence occurs.Limited experience immunosuppressants (azathioprine and methotrexate) suggests lack of benefit. 4Weight loss was a feature in about half the cases described systemic symptoms such as fever arthralgia may also be present.Iron deficiency anaemia has not, we think, been previously presenting complaint.
Purpose: Poor levator function (LF) blepharoptosis can be corrected surgically using frontalis muscle suspension with a variety of materials. Autogenous grafts such as fascia lata are commonly used. The need for remote surgical site and the risk an unattractive leg scar makes use autogenous temporalis (ATF) graft appealing is concealed in hair. We describe pleated, lengthened ATF that easy to prepare insert, provides cosmetically acceptable outcome.Methods: Prospective case series describing...
(1) Background: Meibomian gland dysfunction (MGD) among patients with diabetes mellitus (DM) is a common manifestation of dry eye syndrome (DES). (2) Methods: The purpose this study to identify clinical parameters and biomarkers useful improve the follow-up treatment these patients. We have used an ocular surface disease index (OSDI) questionnaire, Schirmer test I/II, tear film break-up time (TF-BUT), fluorescein plus lissamine green staining, Marx's line (ML), meibomian (MGs) morphology...
When making a cost-saving it is important to ensure there no loss of efficacy.Clinical effectiveness and efficiency incobotulinumtoxinA compared onabotulinumtoxinA in facial dystonia unclear. Our aim evaluate switching from the treatment essential blepharospasm (EB), hemifacial spasm (HFS) aberrant nerve regeneration (AFR).A retrospective study prospective, single-masked switchover audit incobotulinumtoxinA.Twenty EB, 12 HFS six AFR patients.A stable using 1:1 unit ratio contemporaneous...
To report the etiology, management, and possible risk factors for diplopia after canalicular bypass surgery.A multicenter retrospective, noncomparative case series of patients who developed following surgery were assessed.Twenty-four cases identified across 12 institutions. Tubes inserted as a primary procedure with external dacryocystorhinostomy (DCR) (1; 4%) or without DCR (10; 42%) secondary (8; 33%) endonasal (5; 21%) DCR. Factors predisposing to local damage noted in 17 (71%): these...
A 16-year-old boy presented with a 4-week history of sudden onset and progressively worsening occipital headache. Symptoms were exacerbated on sitting standing, initially alleviated recumbency extensive neck flexion. There was no medical or familial history. He keen line skater, regularly executing back flips skating ramp. However, there …
A 16-year-old boy presented with a 4-week history of sudden onset and progressively worsening occipital headache. Symptoms were exacerbated on sitting standing, initially alleviated recumbency extensive neck flexion. There was no medical or familial history. He keen line skater, regularly executing back flips skating ramp. However, there trauma sustained preceding the …
The incidence of skin cancer is increasing and surgery the mainstay management. James Lind Alliance (JLA) priority setting partnership (PSP) was designed to address research uncertainties in surgery. We report outcome top ten priorities from JLA PSP
Abstract Background Peri-orbital surgical emphysema is a rare complication that can occur after lacrimal surgery. It has only been described in isolated cases, following external dacryocystorhinostomy ( n = 2) and Lester Jones tube insertion 1). Method A retrospective, non-comparative case series was conducted of patients who developed endoscopic dacryocystorhinostomy. Results total 356 cases (primary, 316; revision, 40) were performed over six-year period. Seven post-operative identified,...
Basal cell carcinoma (BCC) is associated with aberrant Hedgehog (HH) signalling through mutational inactivation of PTCH1; however, there conflicting data regarding MEK/ERK in BCC and the pathway interactions these carcinomas. To address this, expression active phospho (p) MEK ERK was examined a panel 15 non-aggressive 14 aggressive BCCs. Although not uniformly expressed, both phospho-proteins were detected nuclei and/or cytoplasm normal tumour-associated epidermal cells whereas phospho-MEK...
Primary blepharospasm is an adult-onset focal dystonia characterised by involuntary contractions of the orbicularis oculi, leading to bilateral spasmodic closure eyelids. While spasms this muscle constitute hallmark disease, other motor manifestations include increased spontaneous blinking and apraxia eyelid opening. Originally misdiagnosed as a psychiatric condition, now well established being neurological origin although questions remain its pathophysiological mechanisms. We report...