A5101901755- Chemical Synthesis and Analysis
- Carbohydrate Chemistry and Synthesis
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- Organophosphorus compounds synthesis
- Inorganic and Organometallic Chemistry
- Porphyrin and Phthalocyanine Chemistry
- Synthesis of Organic Compounds
- Synthesis and Catalytic Reactions
- Agricultural and Food Sciences
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- Fluorine in Organic Chemistry
- Synthesis and Reactivity of Sulfur-Containing Compounds
- Analytical Chemistry and Chromatography
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- Rural Development and Agriculture
- Asymmetric Synthesis and Catalysis
- Click Chemistry and Applications
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- Microbial Metabolites in Food Biotechnology
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Instituto de Medicina Integral Professor Fernando Figueira
2024
Universidade Estadual do Rio Grande do Sul
2021-2023
National Council for Scientific and Technological Development
2021-2023
Institut Charles Gerhardt Montpellier
2012
Université de Montpellier
2012
Universidade Federal do Rio Grande do Sul
2005-2008
Hôpital Maison Blanche
2006
Sanofi (France)
1990-1993
Chimie ParisTech
1993
Inserm
1978-1992
ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTSynthesis and biological activities of some pseudo-peptide analogs tetragastrin: the importance peptide backboneJean Martinez, Jean Pierre Bali, Marc Rodriguez, B. Castro, R. Magous, Jeanine Laur, Marie Francoise LignonCite this: J. Med. Chem. 1985, 28, 12, 1874–1879Publication Date (Print):December 1, 1985Publication History Published online1 May 2002Published inissue 1 December...
Several protease inhibitors were found in the seeds of a Cucurbitacea, Ecballium elaterium , and separated from one another by affinity molecular sieve chromatography. Three main trypsin iso‐inhibitors purified ion‐exchange chromatography sequence major one, EETI II, was elucidated compared with other squash family. It is peptide M.W. 3020 strong inhibitory activity (Ka = 8 × 10 11 M ‐1 ) against trypsin, showing high Gly content, six half‐cystine residues, but devoid histidine, threonine,...
Antibodies were raised against a synthetic tetradecapeptide which is component of the non-renin portion (prosegraent) human renin precursor. Inactive from kidney and plasma strongly adsorbed to gel coupled iramunoglobulins purified such an antiserum. These results suggest that renal circulating inactive renins contain in their structure prosegment prorenin.
The primary structure of human preprorenin has recently been determined from its cDNA sequence. It includes a 46-amino acid NH2-terminal prosegment. Six peptides corresponding to the entire prosegment (9-40), except for (1-8) and COOH-terminal (41-46) ends have synthesized. These were tested their inhibitory effect on plasma renin activity. Boc-Tyr-Thr-Thr-Phe-Lys-Arg-Ile-Phe-Leu-Lys-Arg-Met-Pro-OMe (where Boc represents t-butoxycarbonyl OMe methoxy) (h Y(9-20) fragment...
Abstract The three disulfide Ecballium elaterium trypsin inhibitor II (EETI II) reduction with dithiothreitol (DTT) and re‐oxidation of the fully reduced derivative have been examined. A common stable intermediate has observed for both processes. Isolation sequencing carboxymethylated material showed that lacks [2–19] bridge. NMR study a very strong structural conservation as compared to native EETI II, suggesting bridges are [9–21] [15–27] ones. differences occurred in sections 2–7...
The complete sequence of the structural gene coding for mouse submaxillary gland renin was recently reported and amino acid preprorenin deduced. This includes a 45-amino peptide that corresponds to prosegment precursor. To investigate whether peptides related are able inhibit activity, we have synthesized four having following structures: Arg-Ile-Pro-OMe, butyloxycarbonyl(Boc)-Leu-Lys-Lys-Met-Pro-OMe, Boc-Arg-Ile-Pro-Leu-Lys-Lys-Met-Pro-OMe, Boc-Glu-Arg-Ile-Pro-Leu-Lys-Lys-Met-Pro-OMe...
Four homologues of pepstatin, the potent but poorly soluble inhibitor aspartic proteinases, were synthesized by coupling to C-terminus natural pentapeptide following amino acid residues: L-arginine methyl ester, L-aspartic acid, L-glutamic and dipeptide L-aspartyl-L-arginine. The peptide-coupling reagent we used, benzotriazolyloxytris(dimethylamino)phosphonium hexafluorophosphate, allowed us obtain readily pure pepstatin with high yields (60-83%). Pepstatylarginine ester pepstatylglutamic...
Several species of the genus Paspalum L. are important forages, due their to quality, productivity and tolerance environmental stresses. Chromosome numbers, meiotic configurations pollen fertility were evaluated in a collection 85 accessions notatum Flügge seven Pensacola (P. var saurae). All P. tetraploid, with 2n = 4x 40, except one diploid accession, considered as an escape Pensacola. plants had 2x 20. Meiotic at diakinesis metaphase I varied among tetraploid accessions, from only...
Polyclonal and monoclonal antibodies were raised against pure human renin, but nothing was known about the regions which they directed.Using a three-dimensional model of mouse submandibular we selected seven peptide sequences as belonging to potential epitopes.The main criteria for their choice location near catalytic region on surface renin molecule hydrophilicity, After transposition 340-amino acid sequence peptides (corresponding amino acids 287-295) synthesized, coupled bovine serum...
The syntheses of pseudo‐tetrapeptides Boc‐Trp‐ψ(CH 2 ‐NH)‐Met‐Asp‐Phe‐NH 21 and Boc‐Trp‐Met‐ψ(CH ‐NH)‐Asp‐Phe‐NH 20 , representing the C ‐terminal tetrapeptide sequence gastrin, in which amide bonds were replaced by CH ‐NH bond, are described, as well pseudo‐peptide analogues ‐NH)‐Nle‐Asp‐Phe‐NH 16 Boc‐Trp‐Nle‐ψ(CH 11 Boc‐Trp‐Nle‐Asp‐ψ(CH ‐NH)‐Phe‐NH 5 methionyl residue was a norleucyl residue. Pseudo‐peptides bond between Trp Met (or Nle) substituted ‐NH) stimulated gastric acid secretion...
Oxyntomodulin is a peptide isolated from porcine intestine which consists of the whole glucagon sequence extended at its C-terminal part by basic octapeptide. The analogue (Nle-27)-oxyntomodulin human has been synthesized solid-phase synthesis, purified HPLC and identified. Its biological activities are same as those natural hormone.
Uma fração significativa da safra produzida no Brasil é perdida durante o armazenamento. O objetivo do estudo foi avaliar a qualidade de grãos milho armazenados com diferentes umidades iniciais em ambientes hermético e não hermético. Os foram tonéis metálicos 200 litros, sendo que, ambiente hermético, tonel fechado tampa e, utilizada tampa, partir três (13,0, 17,0 29,0%). No início armazenamento cada dois meses, até oitavo mês armazenamento, realizadas as seguintes análises: umidade;...