A5082207605- Antioxidant Activity and Oxidative Stress
- Fatty Acid Research and Health
- Cholesterol and Lipid Metabolism
- Edible Oils Quality and Analysis
- Vitamin C and Antioxidants Research
- Coconut Research and Applications
- Natural Antidiabetic Agents Studies
- Phytochemicals and Antioxidant Activities
- Atherosclerosis and Cardiovascular Diseases
- Metabolism and Genetic Disorders
- African Botany and Ecology Studies
- Folate and B Vitamins Research
- Ginger and Zingiberaceae research
- Eicosanoids and Hypertension Pharmacology
- Helicobacter pylori-related gastroenterology studies
- Medicinal Plants and Neuroprotection
- Piperaceae Chemical and Biological Studies
- Cardiac Fibrosis and Remodeling
- Free Radicals and Antioxidants
- Medicinal Plant Studies
- Neonatal Health and Biochemistry
- Drug-Induced Hepatotoxicity and Protection
- Receptor Mechanisms and Signaling
- Coenzyme Q10 studies and effects
- Psidium guajava Extracts and Applications
National University of Malaysia
2016-2025
Prince of Songkla University
2021
University Kebangsaan Malaysia Medical Centre
2012-2020
Universiti Tun Abdul Razak
2017
OBJECTIVES: This study was conducted to determine whether the blood pressure-lowering effect of Nigella sativa might be mediated by its effects on nitric oxide, angiotensin-converting enzyme, heme oxygenase and oxidative stress markers.METHODS: Twenty-four adult male Sprague-Dawley rats were divided equally into 4 groups.One group served as control (group 1), whereas other three groups (groups 2-4) administered L-NAME (25 mg/kg, intraperitoneally).Groups 3 given oral nicardipine daily at a...
Rutin has been demonstrated to possess potential cardioprotective effects in cardiac remodeling. Thus, the purpose of this review is present gathered information on roles rutin remodeling, which gained attention as a therapeutic target pathology, particularly heart failure. Such studies are focusing more secondary manifestations and primary endpoints dysfunction, rather than targeting cellular molecular mechanisms that responsible for disease progression. Recent scientific evidence revealed...
This study was performed to explore the effects of virgin coconut oil (VCO) in male rats that were fed with repeatedly heated palm on blood pressure, plasma nitric oxide level, and vascular reactivity. Thirty-two Sprague-Dawley divided into four groups: (i) control (basal diet), (ii) VCO (1.42 mL/kg, oral), (iii) five-times-heated (15%) (5HPO), (iv) oral) (5HPO + VCO). Blood pressure significantly increased group given 5HPO diet compared group. lower than Plasma (NO) level group, whereas NO...
Parkia speciosa Hassk., or stink bean, is a plant indigenous to Southeast Asia. It consumed either raw cooked. has been used in folk medicine treat diabetes, hypertension, and kidney problems. contains minerals vitamins. displays many beneficial properties. Its extracts from the empty pods seeds have high content of total polyphenol, phytosterol, flavonoids. demonstrates good antioxidant activity. hypoglycemic effect reported be attributable presence β -sitosterol, stigmasterol,...
Summary Thermally oxidized oil generates reactive oxygen species that have been implicated in several pathological processes including hypertension. This study was to ascertain the role of inflammation blood pressure raising effect heated soybean rats. Male S prague‐ D awley rats were divided into four groups and fed with following diets, respectively, for 6 months: basal diet (control); fresh ( FSO ); five‐time‐heated (5 HSO or 10‐time‐heated (10 ). Blood measured at baseline monthly using...
BackgroundIt is a common practice to heat cooking oil and reuse it in order cut expenses. The use of repeatedly heated predisposes various cardiovascular diseases. Virgin coconut (VCO) reported possess antioxidant action.AimThe study aimed determine the effect heating VCO on blood pressure (BP) inflammatory bio-markers.MethodsThirty male Sprague-Dawley rats were divided into five groups fed with following diet for 24 weeks: normal rat chow (control); + fresh (FVCO); once (1HVCO); times...
Context: Virgin coconut oil (VCO) contains high antioxidant activity which may have protective effects on the heart in hypertensive rats.Objectives: The study investigated of VCO blood pressure and cardiac tissue by measuring angiotensin-converting enzyme (ACE) its histomorphometry rats fed with a heated palm (HPO) diet.Materials methods: Thirty-two male Sprague–Dawley were randomly divided into four groups: (i) control, (ii) orally given (1.42 ml/kg), (iii) HPO (15%) diet, (iv) diet...
Rutin is a flavonoid with antioxidant property. It has been shown to exert cardioprotection against cardiomyocyte hypertrophy. However, studies regarding its antihypertrophic property are still lacking, whether it demonstrates similar effect metabolite, quercetin. Hence, this study aimed investigate the effects of both flavonoids on oxidative stress and mitogen-activated protein kinase (MAPK) pathway in H9c2 cardiomyocytes that were exposed angiotensin II (Ang II) induce Cardiomyocytes Ang...
This study examined the effects of Palm vitamin E (PVE) and α-tocopherol (α-TF) supplementations on adrenalin, noradrenalin, xanthine oxidase plus dehydrogenase (XO + XD) activities gastric lesions in rats exposed to water-immersion restraint stress (WIRS). Sixty male Sprague–Dawley (200-250 g) were randomly divided into three equal sized groups. The control group was given a normal diet, while treated groups received same diet with oral supplementation PVE or α-TF at 60 mg/kg body weight....
This study aimed to investigate the possible gastroprotective effect of tocotrienol against water-immersion restraint stress (WIRS) induced gastric ulcers in rats by measuring its on mucosal nitric oxide (NO), oxidative stress, and inflammatory biomarkers. Twenty-eight male Wistar were randomly assigned four groups seven rats. The two control administered vitamin-free palm oil (vehicle) treatment given omeprazole (20 mg/kg) or (60 orally. After 28 days, from one group both treated subjected...