A5085832671- Synthesis and biological activity
- Synthesis and Characterization of Heterocyclic Compounds
- Crystallization and Solubility Studies
- X-ray Diffraction in Crystallography
- Synthesis and Biological Evaluation
- Synthesis of Indole Derivatives
- Cynara cardunculus studies
- Quinazolinone synthesis and applications
- Molecular Sensors and Ion Detection
- Click Chemistry and Applications
- Bioactive Compounds and Antitumor Agents
- Multicomponent Synthesis of Heterocycles
- Phytochemicals and Antioxidant Activities
- Cancer therapeutics and mechanisms
- Graphene and Nanomaterials Applications
- Synthesis and bioactivity of alkaloids
- Phenothiazines and Benzothiazines Synthesis and Activities
- TiO2 Photocatalysis and Solar Cells
- Polysaccharides Composition and Applications
- 14-3-3 protein interactions
- Drug-Induced Hepatotoxicity and Protection
- Microfluidic and Capillary Electrophoresis Applications
- Botanical Research and Applications
- Analytical Chemistry and Sensors
- Microbial Metabolites in Food Biotechnology
Vietnam Academy of Science and Technology
2016-2025
Hanoi University of Science and Technology
2022
University of Science and Technology
2020
Institute of Chemical Technology
2020
Thai Nguyen University
2019-2020
Vietnam National University, Hanoi
2011
Improving lipophilicity for drugs to penetrate the lipid membrane and decreasing bacterial fungal coinfections patients with cancer pose challenges in drug development process. Here, a series of new N-alkylated-2-(substituted phenyl)-1H-benzimidazole derivatives were synthesized characterized by 1H 13C NMR, FTIR, HRMS spectrum analyses address these difficulties. All compounds evaluated their antiproliferative, antibacterial, antifungal activities. Results indicated that compound 2g...
2-Amino-4,6-diarylpyrimidines were synthesized in a two-step procedure using MW irradiation. In vitro and silico experiments showed that 1e is promising stable inhibitor of wild mutant-type ABL1 chronic myeloid leukemia treatment.
Electrochemical sensors based on a GCE modified with rice-shaped bimetallic MOFs incorporated rGO for the detection of lead( ii ) ions.
In this study, a series of 14 Cu (II), Zn Ni (II) and Ag (I) complexes containing bis-benzimidazole derivatives were successfully designed synthesized from 2-(1H-benzimidazole-2-yl)-phenol corresponding metal salt solutions. The compound structures identified by FT-IR, 1H-NMR, powder X-ray diffraction ESI-MS analyses, the presence in was confirmed ultraviolet-visible spectroscopy ICP optical emission spectrometry. Electronic structure calculations also carried out to describe detailed...
In order to explore and develop new anticancer agents, three series of 2-phenylbenzimidazoles, 15-46, were condensed under simple mild conditions using sodium metabisulfite as an oxidation agent another series, 47-55, obtained via a reduction reaction borohydride. All the compounds synthesized evaluated for their in vitro activities against human cancer cell lines. The novel compound 38 was found be most potent multi inhibitor A549, MDA-MB-231, PC3 lines (IC50 values 4.47, 4.68 5.50 μg mL-1,...
Abstract This research aims to create innovative compounds that incorporate 1,2,4‐triazole and exhibit α‐glucosidase inhibitory potential. Similar our previously reported series of N ‐aryl 2‐{[5‐(naphthalen‐1‐ylmethyl)‐4‐phenyl‐4 H ‐1,2,4‐triazol‐3‐yl]thio}acetamide compounds, we explore here 4‐ethyl instead 4‐phenyl as substituent. The synthesis process effectively yielded these with the highest yield reaching up 91 % for compound ‐phenyl‐2‐{[5‐(naphthalen‐1‐ylmethyl)‐4‐ethyl‐4 5 a . Their...
This study reports a simple process of synthesizing and separating 3-substituted indole derivatives, which are 3-aminoalkylated indoles (AAIs, (C8H7N)CH(CnH2n+1N) (C8H7N)CH(CnH2n+1NO)) bis-(3-indolyl) methanes (BIMs, (C8H7N)2CH(CnHn-1O), (C8H7N)2CH(CnHn-2ClO), (C8H7N)2CH(CnHn+1O3)), via an efficient one-pot multicomponent reaction under catalyst-free conditions. The structures all obtained compounds were determined FT-IR, 1D 2D NMR, HRMS. Fourteen novel (4f–p 5e−g) reported for the first...
Abstract The Diosmetin Phytosome (Dt‐Ph) was developed to enhance the complex's aqueous solubility and in vitro drug release compared pure (Dt). process variables such as reactants’ molar ratio, reaction time, stirring speed, temperature were varied identify most appropriate conditions for synthesis. resulting Dt‐Ph possessed a particle size of 213.9 nm, zeta potential −115.1 mV, 95.6% encapsulation effectiveness, indicating successful formation phytosome. Scanning electron microscopy (SEM)...
Abstract Diosmetin (DT) exhibits various biological activities, including anticancer, antibacterial, antioxidant, estrogenic, and, most notably, anti‐inflammatory properties. Although it has a great deal of promise for advancement in therapeutic usage, DT yet to be the subject many applicable investigations realm pharmacology or medicine oral dermal form due drawback being insoluble water. In this study, fabrication carboxymethyl cellulose/polyvinyl alcohol (CMC/PVA) nanofibers loaded with...
Natural products from plants are an alternative resource in the search for anti-cancer drugs and can have a direct impact on eliminating cancer cells also reduce side effects. Recently, we isolated few flavonoid quercetin cynaroside leaf of cynara scolymus L artocarpus incisa Vietnam, with cytotoxic activity relatively strong Hela cells. The compound is target, research development agents clinical use. To clarify important nature activity, subject QSAR studies cell line use multiple linear...
Reducing graphene dioxide (rGO) and titanium (TiO2) composites with various rGO/TiO2 ratios were prepared by hydrothermal method, in which rGO was synthesized from powder according to modified Hummers method using microwave. Physico-chemical characteristics of the samples investigated methods N2 adsorption-desorption measurements, X-ray diffraction, Raman, Fourier transform infrared spectroscopy (FT-IR), UV-Vis spectroscopy, scanning electron microscopy (SEM) transmission (TEM). rGO-TiO2...
3-Aminoalkylated indoles, synthesized via a multicomponent Mannich-like reaction, are evaluated for enzyme inhibition; 5e and 5f shown to be prospective multitargeted anticancer agents, the cytotoxic mechanism of action is demonstrated molecular docking study.
Abstract This research has progressed to an effective detection chemosensor of zinc, aluminum ions and oxytetracycline hydrochloride antibiotic based on the fluorescence technique. A straightforward method utilizing microwave irradiation was employed synthesize salen‐type Schiff base ligand N,N′‐bis(salicylaldehyde)4,5‐dichloro‐1,2‐phenylenediamine ( H 2 I ), providing a good 70 % yield. In ethanol, sensor demonstrated remarkable rapidity, selectivity, sensitivity in detecting zinc ions. The...
Sunlight exposure can lead to photoaging that reduces the quality of life, from inside outside. Tomato contains a lot nutrients and valuable compounds which are powerful antioxidants. Hence, utilization safe effective natural for creation phytocosmetic is undoubtedly attractive sustainable development. Herein, small pieces tomato were dried at 60oC 6 hours remove water. The chloroform solvent was used extraction by 1:10 (w/v) ratio 24 without light exposure. yield 0.273% compared with dry...
There are many options for reducing greenhouse gas emissions from energy systems while still meeting the global needs. One of could be renewable energy. Renewable has a huge potential to mitigate climate change, that can also provide people with utilities when using them. energy, if properly implemented, would contribute socio-economic development, access as safe source and reduction negative impacts on environment health. In most demanding conditions, increasing share in mix will require...
In this work, the compounds quercetin and cynaroside of flavonoid derivatives were isolated from Cynara scolymus L. Artocarpus Incisa with toxigenicity activity for Hela cell line. The models QSARMLR (k = 9) R2train 0.955, R2pred 0.932 QSARANN I(9)-HL(5)-O(1) 0.996 0.988 constructed to define pGI50 flavonoids line Hela. model was used predict 10 new designed lead compouds cynaroside. value MARE,% 1.864 predicted results smaller than 3.906% model. anticancer activities cynaroside, coumpounds...