A5033902536- Memory and Neural Mechanisms
- Neuroendocrine regulation and behavior
- Neural dynamics and brain function
- Anxiety, Depression, Psychometrics, Treatment, Cognitive Processes
- Stress Responses and Cortisol
- Nicotinic Acetylcholine Receptors Study
Max Planck Institute of Neurobiology
2019-2021
Ludwig-Maximilians-Universität München
2019-2021
Understanding the neurobiological underpinnings of emotion relies on objective readouts emotional state an individual, which remains a major challenge especially in animal models. We found that mice exhibit stereotyped facial expressions response to emotionally salient events, as well upon targeted manipulations emotion-relevant neuronal circuits. Facial were classified into distinct categories using machine learning and reflected changing intrinsic value same sensory stimulus encountered...
How does the brain maintain fear within an adaptive range? We found that insular cortex acts as a state-dependent regulator of is necessary to establish equilibrium between extinction and maintenance memories in mice. Whereas responsiveness fear-evoking cues increased with their certainty predict harm, this activity was attenuated through negative bodily feedback arose from heart rate decelerations during freezing. Perturbation body-brain communication by vagus nerve stimulation disrupted...