A5032970588- Stress Responses and Cortisol
- Estrogen and related hormone effects
- Neuroscience and Neuropharmacology Research
- Hormonal and reproductive studies
- Menopause: Health Impacts and Treatments
- Advanced Electron Microscopy Techniques and Applications
- Cell Image Analysis Techniques
- Memory and Neural Mechanisms
- Neurogenesis and neuroplasticity mechanisms
- Psoriasis: Treatment and Pathogenesis
- Biotechnology and Related Fields
- Antioxidant Activity and Oxidative Stress
- Circadian rhythm and melatonin
- Genomics, phytochemicals, and oxidative stress
- Dermatology and Skin Diseases
- Pelvic floor disorders treatments
- Neuropeptides and Animal Physiology
- Inflammatory Bowel Disease
- Hypothalamic control of reproductive hormones
- Dermatological diseases and infestations
- Hemophilia Treatment and Research
- Urinary Tract Infections Management
- Health Systems, Economic Evaluations, Quality of Life
- Opioid Use Disorder Treatment
- Advanced Fluorescence Microscopy Techniques
EVERSANA (Canada)
2022
University of Guelph
2013-2019
Cornerstone Research Group (United States)
2019
Abstract Object recognition tasks detect cognitive deficits in transgenic Alzheimer’s disease (AD) mouse models. recognition, however, is not a unitary process, and there are many uncharacterized facets of object processing with relevance to AD. We therefore systematically evaluated 5xFAD 3xTG AD mice clarify the nature recognition-related deficits. Twelve-month-old male female were assessed on for identity spatial multisensory perception. Memory perceptual impairments observed, interesting...
Low free T levels in men are associated with age-related cognitive decline and increased risk for neurotoxicity, resulting disease. The mechanisms underlying these observations remain poorly defined. Although rapid, androgen receptor-dependent activation of ERK has been postulated as a neurotrophic neuroprotective mechanism, actions metabolites such 5α-androstane-3α,17β-diol (3α-diol) may also be involved. We investigated the influence 3α-diol on induction phosphorylation SH-SY5Y human...
The Golgi-Cox method of neuron staining has been employed for more than two hundred years to advance our understanding morphology within histological brain samples. While it is preferable from a practical perspective prepare sections at the greatest thickness possible, in order increase probability identifying stained neurons that are fully contained single sections, this approach limited technical by working distance high-magnification microscope objectives. We report here protocol stain...
The Golgi-Cox method of neuron staining has been employed for more than two hundred years to advance our understanding morphology within histological brain samples. While it is preferable from a practical perspective prepare sections at the greatest thickness possible, in order increase probability identifying stained neurons that are fully contained single sections, this approach limited technical by working distance high-magnification microscope objectives. We report here protocol stain...

 Canada continues to experience an opioid crisis that has had a devastating impact on public health, highlighting the importance of management strategies for use disorder (OUD). Several agonist therapies (OATs) OUD are available in Canada, including recent approvals new brand name drugs and generic versions widely used OATs.
 Coverage criteria OATs comparable across drug plans Canada. Methadone hydrochloride (HCL) combination buprenorphine HCL naloxone (buprenorphine HCL-naloxone...
Dehydroepiandrosterone (DHEA), the most abundant adrenal androgen in primates, is also synthesized from cholesterol brain. Like testosterone, DHEA induces spine synapse formation hippocampus. In female rats, this response blocked by co-administration of an inhibitor aromatase, enzyme responsible for estrogen biosynthesis. males, contrast, hippocampal synaptic to unaffected treatment with aromatase inhibitor. We hypothesized that sex difference might reflect differential dependence responses...

 Several regulatory agencies have implemented processes to facilitate timely access innovative therapies for patients with rare or life-threatening diseases high unmet medical needs, typically additional data-generation requirements address important uncertainties in the existing evidence base at time of approval. Many health technology assessment (HTA) adapted their include time-limited recommendations (TLRs) such therapies, which allows these medications while data are collected...

 This report provides an overview of the evolving therapeutic landscape for moderate to severe ulcerative colitis (UC), including recent changes clinical practice guidelines, key trends in strategies, and new or emerging treatment options, with a focus on biologics small-molecule therapies.
 Recent guidelines medical management patients UC include those American Gastroenterological Association (AGA), College Gastroenterology (ACG), European Crohn’s Colitis Organisation (ECCO),...