A5001451559- Multiple Myeloma Research and Treatments
- Protein Degradation and Inhibitors
- Acute Myeloid Leukemia Research
- Platelet Disorders and Treatments
- Breast Cancer Treatment Studies
- Eosinophilic Disorders and Syndromes
- Blood groups and transfusion
- Blood disorders and treatments
- Male Breast Health Studies
- Liver Disease Diagnosis and Treatment
- Peptidase Inhibition and Analysis
- BRCA gene mutations in cancer
- Nasal Surgery and Airway Studies
- Bone and Joint Diseases
- Mast cells and histamine
- Cholangiocarcinoma and Gallbladder Cancer Studies
- Myeloproliferative Neoplasms: Diagnosis and Treatment
- Chemotherapy-related skin toxicity
- Drug-Induced Hepatotoxicity and Protection
- Boron Compounds in Chemistry
- Breast Implant and Reconstruction
- Global Cancer Incidence and Screening
- Occupational Health and Performance
- Ethics in Clinical Research
- Infectious Diseases and Tuberculosis
Holy Spirit University of Kaslik
2025
Mayo Clinic
2024
Mayo Clinic Health System
2019-2023
John Wiley & Sons (United States)
2020
Rosalind Franklin University of Medicine and Science
2016-2018
Captain James A. Lovell Federal Health Care Center
2018
University of Wisconsin–Green Bay
2016
Background Male breast cancer (MBC) is a rare disease for which there limited understanding of treatment patterns and prognostic factors. Methods Men with TNM stage I to III diagnosed between 2004 2014 in the National Cancer Data Base were included. Trends modalities described using average annual percentage change (AAPC) estimated Joinpoint software analysis trends. Kaplan‐Meier curves multivariate Cox proportional hazards regression model used compare survival subgroups identify Results A...
Abstract Introduction Structured data capture requires defined languages such as minimal Common Oncology Data Elements (mCODE). This pilot assessed the feasibility of capturing 5 mCODE categories (stage, disease status, performance status (PS), intent therapy and to change therapy). Methods A tool (SmartPhrase) using existing custom structured elements was Built 4 (disease PS, therapy) typically documented free‐text within notes. Existing functionality for stage supported by Build....
ABSTRACT Background Rhinoplasty is a prominent procedure in facial aesthetics, but extended surgical downtime remains its significant limitation. Nonsurgical rhinoplasty has gained popularity as an alternative, offering aesthetic improvements with minimal downtime. This study evaluates the clinical efficacy and safety of three nonsurgical techniques combined, including hyaluronic acid (HA) filler, botulinum toxin type A (BTX), barbed lifting threads. Methods total 85 patients were included...
1089 Background: T-DXd has become an important treatment option in mBC and other malignancies. Interstitial lung disease/pneumonitis (ILD) occurred 10-14% of pts the DESTINY-Breast trials (0-2% G5 ILD), with potential lower incidence/severity earlier line settings (Krop et al, ASCO 2023). We previously reported Mayo Clinic Rochester, MN experience related ILD (Hoppenworth 2024). Here, we expand data to include patients treated at all locations Enterprise. Methods: retrospectively identified...
1652 Background: Tarlatamab is a bispecific T-cell engager targeting DLL3 that has shown promise as therapy in small cell lung cancer. Administering tarlatamab requires careful consideration of immune-related adverse events (AE), including cytokine release syndrome (CRS) and immune effector cell-associated neurotoxicity (ICANS). Prescribing information recommends patients to be monitored for 22-24 hours an appropriate healthcare setting cycle 1 (C1), days 8. At Mayo Clinic Rochester MN...
e20120 Background: In May 2024, the FDA approved tarlatamab, a Delta-like ligand (DLL3)/CD3-targeted bispecific T-cell engager, for patients with extensive-stage small cell lung cancer (SCLC) disease progression following platinum-based chemotherapy and at least one other prior line of therapy. We aim to evaluate real-world outcomes agent. Methods: conducted retrospective multi-site single center analysis adult who received tarlatamab Mayo clinic sites including Arizona, Florida, Iowa,...
To compare clinical characteristics, treatment patterns, and 30-day all-cause readmission mortality between patients hospitalized for heart failure (HF) before during the coronavirus disease 2019 (COVID-19) pandemic.The study was conducted at 16 hospitals across 3 geographically dispersed US states. The included 6769 adults (mean age, 74 years; 56% [5033 of 8989] men) with cumulative 8989 HF hospitalizations: 2341 hospitalizations COVID-19 pandemic (March 1 through October 30, 2020) 6648 in...
Spur cell haemolytic anaemia (SCA) is a form of that can be seen in patients with severely impaired liver function or advanced cirrhosis. It associated high mortality. The treatment options for SCA secondary to cirrhosis are limited. Our patient middle-aged man who developed and was not candidate transplantation splenectomy. High-dose steroids helped ameliorate haemolysis improve general condition our patient.
Non-cirrhotic, non-malignant portal vein thrombosis (PVT) is commonly secondary to inherited or acquired prothrombotic states. However, even after extensive workup, 25% of patients with PVT have no apparent aetiology identified (idiopathic PVT). Inherited conditions include factor V Leiden, PT mutation and protein C/S/AT deficiency. Acquired APS, PNH BCR-ABL 1-negative myeloproliferative neoplasms (MPN). BCR-ABL-1 negative MPNs are the most frequent underlying risk for (15%-30%). peripheral...
Abstract Aleukemic leukemia cutis (LC) is an extremely rare clinical presentation. All patients eventually develop acute leukemia, mostly monocytic and myelomonocytic types. It a diagnostic challenge, resolved by careful immunophenotyping cytochemistry. The diagnosis indicates poor prognosis. Here, we report case of 85-year-old white male with LC, who had normal peripheral blood bone marrow histology. fragility our patient precluded any definite anti-leukemic therapy.
Cholangiocarcinomas (CCA) are uncommon malignancies that present late and have a poor prognosis. The patients may remain undiagnosed for many years because of non-specific presentation. CCA metastasises commonly to liver adjacent lymph nodes. It can rarely metastasise bone, lung, colon, pancreas, adrenal glands spleen. Multiple treatment options available including surgery, chemotherapy, radiotherapy photodynamic therapy. tumours high rate recurrence most require palliative care. Our patient...
Developing new and innovative treatments for cancer is an urgent matter. The National Institute of Cancer estimates that Brazil will have 576,000 cases the disease in 2015. Our research group developing radioactive seeds to be use radiotherapy procedures since early 2000’s. We present surface study two our major projects: iodine-125 prostate, brain eye treatment iridium-192 eyecancer treatment.
Aggressive systemic mastocytosis (ASM) is characterized by mast cell accumulation in organs. Though ASM may be associated with other hematological disorders, the association pure red aplasia (PRCA) rare and has not been reported. Pure a syndrome, normochromic normocytic anemia, reticulocytopenia, severe erythroid hypoplasia. The myeloid megakaryocytic lines usually remain normal. Here, we report an unusual case of ASM, presenting PRCA management challenges.
Context: Evaluation for Immune thrombocytopenic purpura leading to diagnosis of advanced pancreatic adenocarcinoma has not been previously reported in literature. Case report:We present a case 72year old male who presented our center with epistaxis, hematuria and prolonged bleeding from leg wound.Complete blood count revealed platelet 2k/uL.A complete physical exam an extensive work up, ruled out other causes thrombocytopenia including drugs, infections, liver disease coagulation...
Background: The association of in-hospital blood pressure variability (BPV) with readmission or survival after acute ischemic stroke (AIS) have not been fully investigated. We evaluated the relationship between intra-individual systolic (SBP) (SBPV) for duration hospitalization, mean SBP, maximal SBP reached and readmission-free survival, all-cause readmission, mortality to one year hospitalization a new (AIS). Methods: measured reached, SBPV as quartiles standard deviations (SD) coefficient...
e15096 Background: Colorectal cancer is the second leading cause of related deaths in United States. As per current screening guidelines, should begin by age 50 and be continued till 75. Routine over 75 years not recommended. Methods: Our primary objective was to compare survival time patients undergoing colonoscopy aged or older those 50-74. The study conducted at Captain James A. Lovell Federal Health Care Center (FHCC), North Chicago, States between 2002 2012. A retrospective chart review...