A5102735536- Cancer Genomics and Diagnostics
- Breast Cancer Treatment Studies
- Sarcoma Diagnosis and Treatment
- Cardiac tumors and thrombi
- Breast Lesions and Carcinomas
- Vascular Tumors and Angiosarcomas
- Vascular Malformations and Hemangiomas
- Teratomas and Epidermoid Cysts
- Cancer, Lipids, and Metabolism
- Brain Metastases and Treatment
- DNA Repair Mechanisms
- Estrogen and related hormone effects
- Cutaneous Melanoma Detection and Management
- Immunotherapy and Immune Responses
- Glioma Diagnosis and Treatment
- Glycosylation and Glycoproteins Research
- CRISPR and Genetic Engineering
- Molecular Biology Techniques and Applications
- Cancer, Stress, Anesthesia, and Immune Response
- Epigenetics and DNA Methylation
- Gastrointestinal disorders and treatments
- Cancer Cells and Metastasis
- Bone Tumor Diagnosis and Treatments
- RNA Interference and Gene Delivery
The University of Queensland
2012-2021
Douglass Hanly Moir Pathology
2020
Royal Brisbane and Women's Hospital
2018
Royal Prince Alfred Hospital
2016-2018
QIMR Berghofer Medical Research Institute
2018
Westmead Hospital
2015
How cancer cells adapt to stress Bacteria harsh conditions such as antibiotic exposure by acquiring new mutations, a process called stress-induced mutagenesis. Cipponi et al. investigated whether similar programs of mutagenesis play role in the response targeted therapies. Using vitro models intense drug selection and genome-wide functional screens, authors found evidence for an analogous showed that it is regulated mammalian target rapamycin (mTOR) signaling pathway. This pathway appears...
Drugs that target the Renin-Angiotensin System (RAS) have recently come into focus for their potential utility as cancer treatments. The use of Angiotensin Receptor Blockers (ARBs) and Angiotensin-Converting Enzyme (ACE) Inhibitors (ACEIs) to manage hypertension in patients is correlated with improved survival outcomes renal, prostate, breast small cell lung cancer. Previous studies demonstrate Type I (AT1R) linked pathogenesis, unbiased analysis gene-expression identifying significant...
Aims A better understanding of the expression cancer/testis antigens ( CTA s) in breast cancer might enable identification new immunotherapy options, especially for triple‐negative TN ) tumours, which lack conventional therapeutic targets oestrogen receptor, progesterone and human epidermal growth factor receptor 2. The aim this study was to quantify MAGE ‐A NY ‐ ESO ‐1 s cancer, relate known clinicopathological parameters. Methods results We surveyed an unselected cohort 367 tumours (of 65...
Recurrent Ewing sarcoma breakpoint region 1 (EWSR1) gene rearrangements characterize a select group of bone and soft tissue tumours. In our routine diagnostic practice with fluorescence in-situ hybridization (FISH), we have occasionally observed EWSR1 in tumours not associated classically translocations. This study aimed to review institutional experience this phenomenon also highlight the occurrence unusual FISH signals (i.e. 5' centromeric or 3' telomeric signals) that do fulfil published...
Fluorescence in situ hybridization (FISH) is an important ancillary tool for the classification of bone/soft tissue (BST) tumors. The aim this study was to evaluate contribution FISH final common BST entities molecular pathology department Royal Prince Alfred Hospital (RPAH), which one most referral centers management sarcomas Australia.All routine diagnostic tests performed on formalin-fixed paraffin embedded (FFPE) specimens at RPAH a 5-year period (February, 2010-November, 2015) were...
Seeding of a central nervous system malignancy to the abdominal cavity is an uncommon but well documented complication ventriculoperitoneal (VP) shunt. However, metastasis primary gastrointestinal cancer skin via VP shunt extremely rare. We report clinical case 85-year-old male who presented with right upper quadrant nodule over his shunt, which on histopathology and tumour marker profile was diagnosed as adenocarcinoma likely origin. This illustrates importance proceeding biopsy inform...
A bstract Background Intratumoural heterogeneity is a poor prognostic feature in triple-negative breast cancer (TNBC) and other high-grade malignancies. It caused by genomic instability phenotypic plasticity, but how these features co-evolve during tumour development remains unclear. SOX10 transcription factor, neural crest stem cell (NCSC) specifier candidate mediator of cancer-associated plasticity. Methods Using immunophenotyping, we investigated the expression normal human tissue (n=21...