A5047075846- Radiation Therapy and Dosimetry
- Effects of Radiation Exposure
- Spaceflight effects on biology
- MicroRNA in disease regulation
- Radiation Effects and Dosimetry
Columbia University
2020
Space radiation inhibits angiogenesis by two mechanisms depending on the linear energy transfer (LET). Using human 3D micro-vessel models, blockage of early motile stage was determined to occur after exposure low LET ions (<3 KeV/AMU), whereas inhibition later stages occurs high (>8 KeV/AMU). Strikingly, combined effect is synergistic, detectible as 0.06 Gy making mixed ion space more potent. Candidates for bystander transmission are microRNAs (miRNAs), and analysis miRNA-seq data from...
We have identified and validated a spaceflight-associated microRNA (miRNA) signature that is shared by rodents humans in response to simulated real spaceflight regulates vascular damage deep space radiation. In previous studies, we miRNAs are predicted regulate rodent responses low-Earth orbit. Here the expression of key reacting conditions (exposure ionizing radiation combined with microgravity) astronaut samples from NASA Twin Study. To demonstrate their physiological relevance, utilized...
Space Radiation inhibits angiogenesis by two mechanisms depending on the linear energy transfer (LET). Using human 3D micro-vessel models, blockage of early motile stage was determined to occur after exposure low LET ions (< 3 KeV/AMU) whereas inhibition later stages occurs high (> 8 KeV/AMU). Strikingly, combined effect is synergistic, detectible as 0.6 cGy making mixed ion more potent. Candidates for bystander transmission are microRNAs (miRNAs) and analysis miRNA-seq data from irradiated...