A5071795326- Hemoglobinopathies and Related Disorders
- Hematopoietic Stem Cell Transplantation
- Healthcare Systems and Reforms
- Blood groups and transfusion
- Global Maternal and Child Health
- Mesenchymal stem cell research
- Blood donation and transfusion practices
- Neutropenia and Cancer Infections
- Central Venous Catheters and Hemodialysis
- Renal Transplantation Outcomes and Treatments
- Hepatitis B Virus Studies
- Anesthesia and Pain Management
- Iron Metabolism and Disorders
- Prenatal Screening and Diagnostics
- Ethics and Legal Issues in Pediatric Healthcare
- Organ Donation and Transplantation
- Blood transfusion and management
- Antibiotics Pharmacokinetics and Efficacy
- Transplantation: Methods and Outcomes
- Antibiotic Resistance in Bacteria
- Platelet Disorders and Treatments
- Pluripotent Stem Cells Research
- T-cell and B-cell Immunology
- Erythrocyte Function and Pathophysiology
- CAR-T cell therapy research
Asha Foundation
2017-2025
General Hospital Ernakulam
2017
Introduction This study aimed to the effectiveness of high-performance liquid chromatography (HPLC) as initial step for thalassemia/hemoglobinopathy carrier identification in contrast conventional complete blood count (CBC)-first approach. Materials and methods multicenter was conducted four hospitals South Central India from July 2021 December 2022, enrolling 6,549 antenatal women. Complete HPLC tests beta-thalassemia trait common variants were performed. Cost-effectiveness efficacy three...
Matched-related bone marrow transplantation (BMT) may cure >80% of low-risk children with severe thalassemia (ST). Very long-term follow-up studies have shown how the standard busulfan-cyclophosphamide (BuCy) regimen be associated normalization health-related quality life, no second malignancies in absence chronic graft-versus-host disease, and fertility preservation many patients. However, because BuCy high rejection rates, some centers incorporate thiotepa (Tt) busulfan- or...
Three-loci low-resolution (LR) or intermediate-resolution HLA typing is generally considered adequate in the related blood and marrow transplantation (BMT) context. However, a single high-resolution (HR) mismatch may have similar adverse impact on BMT outcome as an LR one. We sought to determine frequency of mismatches that go undetected when standard (LR 3-loci HR) used compared with 6-loci HR for donor compatibility testing, assess its relevant outcomes. analyzed data from total 2554...
<b>Introduction:</b> Complications associated with blood donation significantly lower odds of subsequent donations. The aim the study is to assess prevalence complications related donation, identify influencing factors, and come up suggestions for minimizing discomfort donors making outdoor voluntary camps safer. <b>Materials Methods:</b> This covered 181 organized by Sankalp India Foundation where 16 banks participated from 01-04-2011 01-08-2014 in Karnataka. Uniform protocols donor...
Thalassemias are the most common inherited genetic disorder in India and a major public health burden with bone marrow transplant (BMT) considered only established curative therapy. We describe outcomes for patients (n = 71) standard-risk thalassemia (liver size < 2 cm age <15 years), receiving BMT 6 low-cost start up centers Indian sub-continent from August-2013 to July-2016. Patients received HLA-matched sibling donor unmanipulated BMT. Conditioning was busulfan (14 mg/kg oral total over...
• Participating centres seemed to achieved reasonable equity in delivery of transfusion therapy. No sex based inequity is seen though fewer girls than boys get enrolled for treatment. Centres offering transport support do not see the impact distance from hospital on patient care. Despite absence factors reviewed, chelation therapy remained sub-optimal.
Successful models of information and communication technology (ICT) applied to cost-effective delivery quality care in low- middle-income countries (LMIC) are an increasing necessity. Severe thalassemia is one the most common life-threatening noncommunicable diseases children globally.The aim was study impact ICT on for severe patients LMIC.A total 1110 with from five centers India were followed over a 1-year period. The consistent use Web-based platform designed assist comprehensive...
The utility of weekly rectal swab surveillance cultures (RSSCs) as a resource to identify gut colonization with extended-spectrum beta-lactamase (ESBL)-producing Escherichia coli or Klebsiella pneumoniae carbapenemase (KPC)-producing organisms and guide empirical antibiotic therapy in hematopoietic stem cell transplantation (HSCT) recipients continues be subject interest. There is an urgent need assess justify modifications antibiotics based on regional epidemiology patient groups. This...
The compliance of safety and quality parameters laid out by national international guidelines in outdoor blood donation camps has not been studied India. Our study aimed at identifying, monitoring, analyzing, developing preventive strategies for several key associated with the voluntary (VBDC).The covered a total 424 VBDCs various locations Bengaluru, Karnataka (South India) from 2009 to 2013. Seven government hospitals based banks, three private banks two standalone participated included...
Rejection of paternal vs maternal fully matched bone marrow grafts in children with thalassemia
• Mean pre-transfusion Hb was 8.8 g/dl. 99% of blood available on-site. Saline washing red cells seems to be effective in controlling transfusion reactions. Rate reactions 0.7% without pre-medication. Low rates transfusion-transmitted infections were seen. Voluntary donation may reduce transmitted infections. Median duration entire day care stay 8 h (IQR 6–8).
Severe thalassemia syndromes (ST) are highly curable by bone marrow transplant (BMT), but rejection may still occur. We retrospectively analyzed our fully matched related donor transplants to establish if isolated splenomegaly is an independent risk factor for and this can be reduced modifying the conditioning protocol. In study, we compared rates between patients with without in 189 consecutive low-risk ST across 2 sequential regimens: regimen A (August 2013 December 2016): busulfan (14...
Abstract Background Patients with tunneled central venous lines (CVL) may develop bloodstream infections which at times are difficult to control without line removal. Concomitant severe thrombocytopenia platelet transfusion refractoriness is often considered a major contraindication any procedure involving blood vessel. There very little literature on the clinical risks of removal in febrile pancytopenia patients. Procedure We analyzed complications and outcomes all our patients, total 52,...