A5062382705- Effects and risks of endocrine disrupting chemicals
- Sperm and Testicular Function
- Reproductive Biology and Fertility
- Animal Genetics and Reproduction
- Cytomegalovirus and herpesvirus research
- Botulinum Toxin and Related Neurological Disorders
- Genetic and Clinical Aspects of Sex Determination and Chromosomal Abnormalities
- Antibiotics Pharmacokinetics and Efficacy
- Herpesvirus Infections and Treatments
- Protein Interaction Studies and Fluorescence Analysis
- Carcinogens and Genotoxicity Assessment
- Pluripotent Stem Cells Research
- Medical History and Research
- Congenital Anomalies and Fetal Surgery
- Birth, Development, and Health
- Diphtheria, Corynebacterium, and Tetanus
- Sexual Differentiation and Disorders
- Toxic Organic Pollutants Impact
- Drug Transport and Resistance Mechanisms
- Intramuscular injections and effects
Universidade Federal do Paraná
2012-2019
Universidade Federal do Pará
2018
We examined the anogenital distance (AGD) plasticity in rats through manipulation of androgen environment utero and during puberty. Dams were treated from gestation days 13-20 with vehicle, flutamide (20mg/kg/day), di-(2-ethylhexyl) phthalate (DEHP, 750mg/kg/day), or testosterone (1.0mg/kg/day). After weaning, male pups randomly assigned to one four postnatal groups, which received same treatments given prenatally. Sixteen treatment groups established based on combination pre- exposures. The...
Prenatal exposure to phthalates is associated with reproductive and metabolic systems alterations. We investigated the effects of in utero lactational Di-(2-ethyl-hexyl) phthalate (DEHP) Di-n-butyl (DBP) on system glycemic homeostasis male female offspring rats. Pregnant rats were exposed equimolar doses (0.018, 0.18 1.8 mmol/kg/day) DEHP or DBP corresponding 7, 70, 700 mg/kg/day for 5, 50, 500 DBP, respectively, by oral gavage from gestation day 13 postnatal 21, using canola oil as vehicle...
Ganciclovir (GCV) has been implicated in the development of testicular alterations. Exposure on gestational day (GD) 10 rats induced permanent effects, including focal reduction or absence germ cells (Sertoli cell-only tubules). Because timing exposure can be critical for we exposed rat dams to 300 mg/kg GCV (3 100 subcutaneous injections) GD10, 14 and 19, when have high rates migration, proliferation are mitotically quiescent, respectively. Males utero GD10 were evaluated androgenization...
Human exposure to phthalates and other non-persistent chemicals in emerging market countries is largely unknown. A preliminary analysis of urine samples from pregnant Brazilian women indicated the presence metabolites Diisopentyl phthalate (DiPeP). Because its chemical structure, DiPeP probably located hot-spot toxicity. In a rapid approach we tried identify origin exposure, reliably quantify specific human for assessment investigate antiandrogenic potency this rats.We identified iso-amyl...