A5068756156- MicroRNA in disease regulation
- Circular RNAs in diseases
- Cancer-related molecular mechanisms research
- Trypanosoma species research and implications
- Mesenchymal stem cell research
- Connective tissue disorders research
- Epigenetics and DNA Methylation
- Bone fractures and treatments
- Natural product bioactivities and synthesis
- Nerve injury and regeneration
- RNA modifications and cancer
- Galectins and Cancer Biology
- Neurogenesis and neuroplasticity mechanisms
- Extracellular vesicles in disease
- Neuroscience and Neuropharmacology Research
- Liver physiology and pathology
- Muscle Physiology and Disorders
- Cardiomyopathy and Myosin Studies
- Phytochemical Studies and Bioactivities
- Macrophage Migration Inhibitory Factor
- Phytochemistry and Bioactive Compounds
- Hemoglobinopathies and Related Disorders
- Spinal Cord Injury Research
- Microbial Metabolism and Applications
- Bacterial biofilms and quorum sensing
Universidade Estadual de Santa Cruz
2013-2024
Universidade de São Paulo
2011-2017
Universidade de Ribeirão Preto
2009-2016
Hospital São Rafael
2011-2014
Faculdade de Medicina de São José do Rio Preto
2011
Abstract Introduction The administration of stem cells holds promise as a potential therapy for spinal cord injury (SCI). Mesenchymal have advantages clinical applications, since they can be easily obtained, are suitable autologous transplantation and been previously shown to induce regeneration the in experimental settings. Here we evaluated feasibility, safety efficacy mesenchymal subjects with chronic complete SCI. Method We conducted phase I, non-controlled study 14 both genders aging...
Carvacrol, a phenolic monoterpene, has been reported to possess anti-inflammatory properties. However, the mechanisms involved in its pharmacological properties are currently not well understood. In present study, contribution of cytokine modulation effects carvacrol was investigated classical inflammation model: complete Freund's adjuvant (CFA)-induced paw mice. The edema measured using plesthismometer. Paw tissue removed 2 h after inflammatory stimulus determine levels prostaglandin E2...
Head and neck squamous cell carcinoma (HNSCC) is a heterogeneous disease affecting the epithelium of oral cavity, pharynx larynx. Conditions most patients are diagnosed at late stages disease, no sensitive specific predictors aggressive behavior have been identified yet. Therefore, early detection prognostic biomarkers highly desirable for more rational management disease. Hypermethylation CpG islands one important epigenetic mechanisms that leads to gene silencing in tumors has extensively...
Diabetes mellitus (DM) is one of the most common and serious chronic diseases in world. Here, we investigated effects mouse dental pulp stem cell (mDPSC) transplantation a streptozotocin (STZ)-induced diabetes type 1 model. C57BL/6 mice were treated intraperitoneally with 80 mg/kg STZ transplanted × 10(6) mDPSCs or injected saline, by an endovenous route, after onset. Blood urine glucose levels reduced hyperglycemic when compared to saline-treated controls. This correlated increase...
The majority of Osteogenesis Imperfecta (OI) cases are caused by mutations in one the two genes, COL1A1 and COL1A2 encoding for chains that trimerize to form procollagen 1 molecule. However, alterations gene expression microRNAs (miRNAs) responsible regulation cell fate determination may be evolved OI phenotype. In this work, we analyzed coding region intron/exon boundaries genes sequence analysis using an ABI PRISM 3130 automated sequencer Big Dye Terminator Sequencing protocol. miR-29b...
Introduction: Breast cancer represents the most prevalent malignancy among women. Recent advancements in translational research have focused on identification of novel biomarkers capable providing valuable insights into patient outcomes. Furthermore, comprehensive investigations aimed at discovering miRNAs, unraveling their biological functions, and deciphering target genes significantly contributed to our understanding roles miRNAs play tumorigenesis. Consequently, these facilitated way for...
Chagas disease, caused byTrypanosoma cruzi infection, is a leading cause of heart failure in Latin American countries.In previous study, we showed beneficial effects granulocyte colony-stimulating factor (G-CSF) administration the function mice with chronic T. infection.Presently, investigated mechanisms by which this cytokine exerts its effects.Mice chronically infected were treated human recombinant G-CSF (3 courses 200 g/kg/d for 5 d).Inflammation and fibrosis reduced hearts G-CSFtreated...
Abstract Objective To evaluate the expression of a set miRNAs to identify differentially expressed that might be considered reliable biomarkers on Diabetic Retinopathy (DR) blood samples. Results Expression levels MiR-320a, MiR-342-3p, MiR-155, MiR-99a, MiR-29a and MiR-27b were analyzed in 60 healthy controls, 48 Diabetes Melitus (DM) without DR patients 62 by qRT-PCR. MiR-320a was shown downregulated plasma compared with DM subjects. Target genes predicted using miRWalk3.0, miR targeting...
Hecogenin is a steroidal sapogenin largely drawn from the plants of genus Agave, commonly known as ‘sisal’, and one important precursors used by pharmaceutical industry for synthesis steroid hormones. acetate (HA) sapogenin-acetylated that produces antinociceptive activity. Thus, we evaluate antihyperalgesic profile HA in mice inflammatory models, well its possible involvement with c-fos expression on spinal cord area cytokines to analgesic profile. Acute pretreatment (5, 10, or 20 mg/kg;...
Recent evidence suggests that cell-derived circulating miRNAs may serve as biomarkers of cardiovascular diseases. However, a few studies have investigated the potential for left ventricular hypertrophy (LVH). In this study, we aimed to characterize miRNA profiles could distinguish hypertensive patients with LHV, without LVH and control subjects, identify LVH. was defined by mass indexed body surface area >125 g/m2 in men >110 women were classified when presenting systolic blood pressure 140...
Background: Chagas disease, caused by the protozoan Trypanosoma cruzi, is a major cause of heart failure in Latin America.Tissue therapy has been investigated as possible therapeutic option for patients with cardiovascular disease.Objective: This study evaluated effects mesenchymal stem cells an experimental model chronic Chagasic cardiomyopathy.Methods: C57BL/6 mice were infected 1000 trypomastigotes from T. cruzi Colombian strain and, after six months infection, treated human...
Abstract Diabetic Retinopathy, the main cause of visual loss and blindness among working population, is a complication Diabetes mellitus (DM), which has been described as major public health challenge, so it important to identify biomarkers predict stratify patient´s possibility for developing DR. MicroRNAs (miRNAs) are small non-coding RNA molecules that have showed be promising disease association miRNAs with develop DR reported. However, evaluating miRNA expression involves normalization...
Summary Infection by Trypanosoma cruzi , the aetiological agent of Chagas disease, causes an intense inflammatory reaction in several tissues, including myocardium. We have previously shown that transplantation bone marrow cells ( BMC ) ameliorates myocarditis a mouse model chronic disease. investigated participation lesion repair heart and skeletal muscle, caused T. infection mice. with myotropic strain induced increase percentage stem monocytes peripheral blood, as well gene expression...
Fungi from the widely distributed genus Trichoderma are of great biotechnological interest, being currently used in a vast range applications. Here, we report that high-molecular weight fraction (HWF) derived asperelloides ethanolic extract exhibits antibiotic activity against staphylococcal biofilms. The antibacterial and anti-biofilm properties T. extracts were evaluated by well-established assays Staphylococcus aureus ATCC strains (29213 6538) one clinical isolate bovine mastitis. HWF...
Stroke is one of the most common causes death and incapacity in world. The benefits reperfusion therapies hospitalization neurologic intensive care units (ICUs) are undeniable. However, these treatments not widely available a continental-sized country like Brazil.
Osteogenesis Imperfecta (OI) (OMIM %259450) is a heterogeneous group of inherited disorders characterized by increased bone fragility, with clinical severity ranging from mild to lethal. The majority OI cases are caused mutations in COL1A1 or COL1A2. Bruck Syndrome (BS) further recessively-inherited OI-like phenotype which fragility associated the unusual finding pterygia and contractures large joints. Notably, several studies have failed show any abnormalities biosynthesis collagen 1 BS...