Abstract The purpose of this investigation was to study the prevalence C‐shaped roots, root canal orifices, and canals in mandibular second molars a Chinese population. A total 581 were collected Hong Kong Taiwan. teeth demineralized placed methyl salicylate induce transparency. pulp chamber floor examined ascertain number orifices. ink then injected into system demonstrate anatomy. had separate roots 66.4%, cone‐shaped 2.1% 31.5%. orifices 68.3% (21.5% whole material). True observed 65.8%...

Objectives/Hypothesis Thermal injury to the recurrent laryngeal nerve (RLN) may not be visually apparent and go unrecognized intraoperatively. This study aimed investigate heat thermal tolerance of RLN evaluate electrophysiologic correlates electromyographic (EMG) signal change during an acute damage. Study Design Prospective porcine model with continuous intraoperative neuromonitoring (CIONM). Methods Ten pigs (20 RLNs) undergoing CIONM had their EMG tracings recorded correlated heated...

Background: Recurrent laryngeal nerve (RLN) palsy remains a major source of morbidity after thyroid surgeries. Intraoperative neural monitoring (IONM) has gained increasing acceptance as an adjunct to standard practice visual RLN identification. Endotracheal tube (ETT) surface recording electrodes systems are now widely used for IONM; however, malpositioned ETT can cause false IONM results and requires time-consuming intraoperative verification the position readjustment by anesthesiologist....

Intraoperative neural monitoring (IONM) has gained widespread acceptance as an adjunct to the gold standard of visual identification recurrent laryngeal nerve (RLN) during thyroid surgery. Currently, electromyography (EMG) recording IONM is almost always performed using endotracheal tube (ETT) surface electrodes placed adjacent vocal folds originating from inner cartilage (TC). Therefore, it was hypothesized that on outer TC should enable access EMG response IONM. The aim this experimental...

Objectives/Hypothesis This study investigated recurrent laryngeal nerve (RLN) real-time electromyography (EMG) data to define optimal safety parameters of the LigaSure Small Jaw (LSJ) instrument during thyroidectomy. Study Design Prospective animal model. Methods Dynamic EMG tracings were recorded from 32 RLNs (16 piglets) various applications LSJ around using continuous electrophysiologic monitoring. At varying distances RLN, was activated (activation study). The also applied RLN at timed...

Over the past decade, use of neuromonitoring in thyroid surgery has become well established and is increasing accepted across world. In addition, new developments energy devices have significantly improved efficacy achieving hemostasis surgery. Few studies focused on complication rates device-assisted sutureless neuro-monitored thyroidectomy. This study investigates a novel LigaSure Small Jaw (LSJ) technique for thyroidectomy compares surgical between LSJ conventional clamp-and-tie one...

Purpose: To examine the effect of hospital volume on positive surgical margin (PSM) and biochemical-failure-free survival (BFS) rates in patients with prostate cancer (PC) undergoing robotic-assisted or nonrobotic-assisted radical prostatectomy (RP). Patients Methods: The were men collected National Taiwan Cancer Registry diagnosed as having PC without distant metastasis who received RP from 44 multi-institutes Taiwan. logistic regression method was used to analyze risk PSM included (i.e.,...

Abstract Elevated levels of NF‐κB are frequently detected in many inflammatory diseases and cancers. Blocking the IKK–NF‐κB pathway has been seen as a promising approach for new therapies. By employing dominant‐negative mutant IKKβ, our data revealed that loss IKKβ activity reduces not only proliferation invasion lung adenocarcinoma A549 cells vitro but also tumour formation, metastasis angiogenesis mouse xenograft model. Treatment inhibitors (CYL‐19s CYL‐26z) leads to arrest cell cycle...

Intraoperative injury to the recurrent laryngeal nerve (RLN) can cause vocal cord paralysis, which interferes with speech and potentially interfere breathing. In recent years, intraoperative neural monitoring (IONM) has been widely adapted as an adjunct technique localize RLN, detect RLN injury, predict function during operations. Many studies have also used animal models investigate new applications of IONM technology develop reliable strategies for preventing injury. The aim this article...

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The purpose of this study was to investigate and define safety parameters for using the Ligasure exact dissector (LED) dissection close recurrent laryngeal nerve (RLN) during thyroidectomy.Real-time electrophysiologic electromyographic (EMG) tracings were recorded in 16 RLNs (8 piglets) various applications LED under continuous intraoperative monitoring prospective porcine model study. In activation study, activated at varying distances from RLN. cooling with different times or after...

Endotracheal tube-based surface electrodes are now commonly applied to measure evoked electromyographic (EMG) response of the vocal cord during monitored thyroidectomy. The aim study was determine incidence difficult intubation and assess effectiveness using video-assisted intubating stylet (Trachway) for EMG tube placement in patients undergoing thyroidectomy.Medical records were collected from consecutive thyroid surgery before after implementation protocol. A total 748 intubated with...

Titration of neuromuscular block (NMB) plays a key role in intraoperative recurrent laryngeal nerve monitoring during thyroid surgery. The combination blocking agent and timely partial reversal NMB was investigated both animal experiments clinical neuro-monitored thyroidectomy.In experiments, 8 piglets received sugammadex to assess the EMG recovery after rocuronium-induced NMB. In monitored thyroidectomy, 40 patients each were allocated conventional group group. Conventional rocuronium 0.3...

Abstract Background Postoperative hypocalcemia (PH) is a serious complication after total thyroidectomy. This study aimed to compare PH rates between LigaSure Small Jaw (LSJ) and clamp‐and‐tie hemostatic technique in patients undergoing Methods Four hundred twenty were divided into two groups: group L (210 patients) performed with LSJ C technique. Serum ionized calcium (iCa) was measured before 12, 24, 48, 72 hours surgery. defined as iCa lower than 4.2 mg/dL at least measurements. Results...

The use of transcartilage (TC) intraoperative neuromonitoring (IONM) in a pediatric population has not been reported. This study evaluated the feasibility and benefit using TC-IONM for thyroid cancer surgery population. retrospective single-center enrolled 33 patients who had received an IONM-assisted thyroidectomy. Demographic characteristics, standardized IONM laryngeal examinations stimulation information (L1-V1-R1-R2-V2-L2) were compared between endotracheal tube (ET) TC methods. In 15...

Intraoperative neuromonitoring can qualify and quantify RLN function during thyroid surgery. This study investigated how the severity mechanism of dysfunction monitored surgery affected postoperative voice. retrospective analyzed 1021 patients that received standardized thyroidectomy. Patients had post-dissection RLN(R2) signal <50%, 50-90% >90% decrease from pre-dissection RLN(R1) were classified into Group A-no/mild, B-moderate, C-severe dysfunction, respectively. Demographic...

Background Neuromuscular blocking agents provide muscular relaxation for tracheal intubation and surgery. However, the degree of neuromuscular block may disturb transmission lead to weak electromyography during intraoperative neuromonitoring. This study aimed investigate a surgeon-friendly titrated sugammadex protocol maintain both neuromonitoring quality surgical thyroid Methods A total 116 patients were enrolled into two groups underwent elective surgery with All followed standardized...

When performing radiofrequency ablation for thyroid nodules, it is essential to avoid thermal injury the recurrent laryngeal nerve. This porcine animal model study used continuous intraoperative neuromonitoring investigate safety parameters of ablation.

Objectives During monitored thyroidectomy, displacement of the recurrent laryngeal nerve (RLN) or vagus (VN) in some complicated cases can increase risk injury. Although increasing stimulus current facilitate mapping and localization, safety a high‐current remains unknown. Therefore, this study evaluated porcine model. Methods Short‐duration (1 minute), (3, 5, 10, 15, 20, 25, 30 mA at 4Hz) pulses were repeatedly applied to RLN VN six anesthetized piglets. The was assessed terms hemodynamic...

Thyrotoxic hypokalemic periodic paralysis (THPP) is a rare, potentially life-threatening endocrine emergency. It characterized by recurrent muscle weakness and hypokalemia. Because many THPP patients do not have obvious symptoms signs of hyperthyroidism, misdiagnosis may occur. The published studies revealed that definitive therapy for control hyperthyroidism medical therapy, radioactive iodine or surgery, but the long-term post-operative follow-up result was observed. We reported two cases...