A5078381318- Cancer-related gene regulation
- Soft Robotics and Applications
- Augmented Reality Applications
- Genetic Syndromes and Imprinting
- Epigenetics and DNA Methylation
- Surgical Simulation and Training
Weizmann Institute of Science
2023
Karlsruhe Institute of Technology
2021
Abstract TET2/3 play a well-known role in epigenetic regulation and mouse development. However, their function cellular differentiation tissue homeostasis remains poorly understood. Here we show that ablation of intestinal epithelial cells results murine phenotype characterized by severe imbalance the small intestine. Tet2/3 -deleted mice pronounced loss mature Paneth as well fewer Tuft more Enteroendocrine cells. Further major changes DNA methylation at putative enhancers, which are...
Neurosurgical interventions in the brain are challenging due to delicate anatomical structures. During surgery, precise navigation of surgical instruments supports surgeons and allows prevention adverse events. Here, an augmented reality-based aid with automated segmentation risk structures path planning is presented. Superimposed patient models visualized during neurosurgical on example ventricular puncture. The proposed system experimentally validated a realistic operating room scenario...