Trust is one of the most important concepts guiding decision-making and contracting in human societies. In artificial societies, this concept has been neglected until recently. The inherent benevolence assumption implemented many multiagent systems can have hazardous consequences when dealing with deceit open systems. aim paper to establish a mechanism that helps agents cope environments inhabited by both selfish cooperative entities. This achieved enabling evaluate trust others. A...

Die Cochrane Collaboration hat 2012 - nach 2000, 2002 und 2009 zum vierten Mal einen Review über die Wirksamkeit von Serenoa repens (Sägepalme) bei benigner Prostatahyperplasie (BPH) publiziert. Im Gegensatz zur positiven Beurteilung 2000 sprechen Publikationen der Sägepalme ab. Doch wie bereits im findet man in Publikation verschiedene Fehler, welche Schlussfolgerungen Autoren infrage stellen.Die Collaboration, ein virtuelles Fachgremium, publiziert Reviews medizinischen Behandlungen. Diese...

Abstract Background Functional dyspepsia ( FD ) is a very common condition affecting more than 10% of the population. While there no cure, few drugs have been found to be effective for relief symptoms, although most are only in subgroup patients. We assess and compare efficacy fixed peppermint/caraway‐oil‐combination (Menthacarin) on symptoms quality life (QoL) patients with consistent epigastric pain syndrome EPS postprandial distress PDS ). Methods In prospective, double‐blind, multicenter...

During recent years, several case reports have been published in which the authors voiced their suspicion of a causal relationship between hemorrhagic complications and intake Ginkgo biloba preparations. Therefore, trial was conducted to investigate influence special extract EGb 761 on hemostasiological parameters. Fifty healthy, male volunteers underwent 7 days crossover treatment with 2 × 120 mg/day placebo randomized sequence. Between two phases, washout-period at least 3 weeks inserted....

Abstract Heartburn and acid regurgitation are main symptoms of gastro-esophageal reflux, a widespread complaint with significant impact on quality life (QoL). Refluthin® for chewable tablets (Refluthin) symptomatic treatment option containing combination an antacid (CaCO 3 , MgCO ) polysaccharide-rich extract mucoprotective substances from Opuntia ficus-indica cladodes. To investigate performance safety Refluthin in the rapid long lasting relief heartburn related gastric discomfort under...

The aim of this prospective, randomized, double-blind, double-dummy, multicenter clinical trial was to investigate the efficacy and safety PRO 160/120 (Prostagutt^® forte), a fixed combination preparation 160 mg Sabal fruit extract WS^® 1473 120 Urtica root 1031 per capsule, in comparison α₁-adrenoceptor antagonist tamsulosin (CAS 106463-17-6) lower urinary tract symptoms (LUTS) caused by benign prostatic hyperplasia (BPH). 140 elderly out-patients suffering...

A simulation model of the flow intermodal terminal units (ITUs) among inland terminals is presented. The are interconnected by rail corridors. Each serves a user catchment area via road network. modelled as set platforms that served number gantry cranes and front lifters. Given schedule train connections terminals, an agent-based system, transport planner (ITP), books ITUs on trains assigns trucks to deliver them source pick up in destination terminal. corridor software has been implemented...

Acute bronchitis commonly associated with cough is predominantly caused by viral infections. The burden on health-care systems and society enormous. A randomised, placebo-controlled, multicentre clinical trial to investigate the efficacy safety of a liquid herbal drug preparation from roots Pelargonium sidoides (EPs 7630) was conducted in 217 adult outpatients acute bronchitis. primary variable symptom score (BSS) ranging 0 20. Primary data this study were already published 2007. Now, we...

Background: Experience in treating human coronavirus (HCoV) infections might help to identify effective compounds against novel coronaviruses. We therefore performed a secondary subgroup-analysis of data from an open-label, uncontrolled clinical trial published 2015 investigating the proanthocyanidin-rich Pelargonium sidoides extract EPs 7630 patients with common cold. Methods: 120 cold and at least 2 out 10 symptoms received one film-coated 20 mg tablet thrice daily for days uncontrolled,...

Introduction: Phytopharmaceutical products are successfully used for acute respiratory infections and may therefore be promising candidates adjuvant symptomatic treatment of COVID-19. In vitro clinical studies suggest that the proprietary Pelargonium sidoides DC. root extract EPs 7630 has antiviral immunomodulatory properties, effects on SARS-CoV-2 propagation have been shown in . Medicinal containing approved viral tract infections. Methods: We present a retrospective review case reports...

The efficacy and tolerability of Pelargonium sidoides DC. root extract EPs 7630 in children with acute bronchitis (AB) have been widely demonstrated. We investigated the safety a syrup formulation an oral solution pre-school children.In open-label, randomized clinical trial (EudraCT number 2011-002652-14), aged 1-5 years suffering from AB received or for 7 days. Safety was assessed by frequency, severity, nature adverse events (AE), vital signs, laboratory values. Outcome measures evaluating...

Cough is a leading symptom of viral acute respiratory infections such as bronchitis (AB) and the common cold (CC), which can be debilitating may persist for several weeks. We investigated whether treatment with Pelargonium extract EPs 7630 reduce cough improve disease-related quality life (QoL).We performed meta-analysis randomized, placebo-controlled trials investigating efficacy in AB or CC. Efficacy analyses included change from baseline intensity score, remission cough,...

The extract EPs 7630 from the roots of Pelargonium sidoides has been proven safe and effective in treatment acute respiratory tract infections (aRTI).The aim this study was to perform a meta-analysis on efficacy patients suffering non-streptococcal tonsillopharyngitis (ATP) or common cold (CC) regarding symptoms sore throat hoarseness.This encompasses double-blind, placebo-controlled, randomized clinical trials investigating ATP CC.Relevant publications were identified by searching PubMed...

Background: Acute bronchitis (AB) has an enormous economic impact through lost working time. We investigated whether treatment with Pelargonium extract EPs 7630 may reduce the time of inability to work. Methods: A meta-analysis double-blind, randomized, placebo-controlled trials adult patients suffering from AB was performed. The average number days work and proportion who were still unable after one week’s assessed. Results: Four clinical a total 1,011 evaluable received marketed dosage...

Abstract Objective In the pediatric population, acute bronchitis (AB) is a leading cause of illness absence from childcare, school, or apprenticeship. We report meta-analysis double-blind, randomized trials with children and adolescents AB (aged 1–18 years), who were treated Pelargonium extract EPs 7630 placebo for 7 days. Methods The average number days absent apprenticeship due to proportion patients still unable return their normal activities at treatment end assessed. Results Literature...