A5103187449- Pharmacological Receptor Mechanisms and Effects
- S100 Proteins and Annexins
- Tryptophan and brain disorders
- Receptor Mechanisms and Signaling
- Nicotinic Acetylcholine Receptors Study
- Pain Mechanisms and Treatments
- Traumatic Brain Injury and Neurovascular Disturbances
- Treatment of Major Depression
- Neuroscience and Neuropharmacology Research
- Pain Management and Placebo Effect
- Neuroinflammation and Neurodegeneration Mechanisms
Beijing Institute of Education
2024-2025
Institute of Basic Medical Sciences of the Chinese Academy of Medical Sciences
2024-2025
Abstract Background: Neurological dysfunction is a common complication of traumatic brain injury (TBI), and early treatments are critical for the long-term prognosis. This study aimed to investigate whether hypidone hydrochloride (YL-0919) improves neurological function impairment in mice with TBI. Methods: TBI was induced adult male C57BL/6J using controlled cortical impact (CCI) method. First, modified severity score (mNSS), rotarod test, Morris water maze (MWM) test were conducted assess...
Background/Objectives: The available treatment for attention deficit is drug therapy, but the drugs show poor adverse effect profiles and individual variability in response, especially adults. Hypidone hydrochloride (YL-0919) a selective sigma-1 receptor agonist that demonstrated faster onset antidepressant our previous studies. Current studies aim to study attention-enhancing mechanism of YL-0919. Methods: We used five-choice serial reaction time task (5-CSRTT) measure attention-improving...
JOURNAL/nrgr/04.03/01300535-202508000-00023/figure1/v/2024-09-30T120553Z/r/image-tiff Traumatic brain injury involves complex pathophysiological mechanisms, among which oxidative stress significantly contributes to the occurrence of secondary injury. In this study, we evaluated hypidone hydrochloride (YL-0919), a self-developed antidepressant with selective sigma-1 receptor agonist properties, and its associated mechanisms targets in traumatic Behavioral experiments assess functional...