A5012413299- Occupational and environmental lung diseases
- Nanoparticles: synthesis and applications
- Graphene and Nanomaterials Applications
- Cancer Research and Treatments
- Carbon Nanotubes in Composites
- Air Quality and Health Impacts
- Occupational exposure and asthma
- Cancer Cells and Metastasis
- Carcinogens and Genotoxicity Assessment
- Heavy Metal Exposure and Toxicity
- Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
- Carbon and Quantum Dots Applications
- 3D Printing in Biomedical Research
- Graphene research and applications
- Immunotoxicology and immune responses
- Microplastics and Plastic Pollution
- Cancer-related Molecular Pathways
- Pleural and Pulmonary Diseases
- Environmental Toxicology and Ecotoxicology
- Tissue Engineering and Regenerative Medicine
- Aluminum toxicity and tolerance in plants and animals
- Advanced Nanomaterials in Catalysis
- Mercury impact and mitigation studies
- Selenium in Biological Systems
- Drug-Induced Hepatotoxicity and Protection
John Brown University
2005-2022
Brown University
2012-2021
Providence College
2003-2020
Center for Nanoscale Science and Technology
2011-2018
Emory University Hospital
2008
Southern Illinois University School of Medicine
2007
Tokai University
2000
Rhode Island Hospital
2000
Union for International Cancer Control
1997
Temple University
1976-1982
Primary cultures of adult rat hepatocytes were treated in the presence or absence extracellular calcium with ten different membrane-active toxins. In all cases more than half cells killed 1 to 6 hours but not calcium. An effect on primary mechanism membrane injury by any agents cannot be implicated. Viability, as determined trypan blue exclusion correlated well other indices viability such plating efficiency and hydrolysis fluorescein diacetate. It is concluded that are processes involve at...
Understanding and controlling the interaction of graphene-based materials with cell membranes is key to development graphene-enabled biomedical technologies management graphene health safety issues. Very little known about fundamental behavior exposed ultrathin 2D synthetic materials. Here we investigate interactions few-layer (FLG) microsheets three types model lipid bilayers by combining coarse-grained molecular dynamics (MD), all-atom MD, analytical modeling, confocal fluorescence...
Graphene-based materials are shown to be a new class of antioxidants. They show promise as dispersed oxidation retarders, 2D antioxidant coatings, and 3D encapsulation shells that passivate redox-active surfaces.
The widespread use of silver nanoparticles (Ag-NPs) in consumer and medical products provides strong motivation for a careful assessment their environmental human health risks. Recent studies have shown that Ag-NPs released to the natural environment undergo profound chemical transformations can affect bioavailability, toxicity, risk. Less is known about Ag-NP biological systems, though literature clearly reports chronic ingestion produces argyrial deposits consisting silver-, sulfur-,...
Copper-based nanoparticles are an important class of materials with applications as catalysts, conductive inks, and antimicrobial agents. Environmental safety issues particularly for copper-based nanomaterials because their potential large-scale use high redox activity toxicity reported from in vitro studies. Elemental nanocopper oxidizes readily upon atmospheric exposure during storage use, so copper oxides highly relevant phases to consider studies environmental health impacts. Here we...
Material stability and dissolution in aqueous media are key issues to address the development of a new nanomaterial intended for technological application. Dissolution phenomena affect biological environmental persistence; fate, transport, biokinetics; device product stability; toxicity pathways mechanisms. This article shows that MoS2 nanosheets thermodynamically kinetically unstable O2-oxidation under ambient conditions variety media. The oxidation is accompanied by nanosheet degradation...
Engineered nanomaterials (ENMs) are increasingly entering the environment with uncertain consequences including potential ecological effects.Various research communities view differently whether ecotoxicological testing of ENMs should be conducted using environmentally relevant concentrations-where observing outcomes is difficult-versus higher ENM doses, where responses observable.What exposure conditions typically used in assessing hazards to populations?What test ecosystem-scale...
Hungry nanotubes: Single-walled carbon nanotubes (SWNTs) compete with cells by interacting folate and other essential micronutrients in cell culture medium (see picture). Sequestering of can cause apparent toxicity even without direct nanotube–cell contact through a new "starvation" mechanism.
Water microdroplets containing graphene oxide and a second solute are shown to spontaneously segregate into sack-cargo nanostructures upon drying. Analytical modeling molecular dynamics suggest the sacks form when slow-diffusing preferentially accumulates adsorbs at receding air–water interface, followed by capillary collapse. Cargo-filled nanosacks can be nanomanufactured simple, continuous, scalable process promising for many applications where nanoscale materials should isolated from...
The biomolecular mechanism of nickel carcinogenicity is driven by intracellular Ni cation. role catalyst in single-wall carbon nanotube toxicity will therefore depend on its bioavailability, which highly uncertain due to encapsulation shells. This article measures the material-specific release into extra- and physiological fluid phases suggests practical techniques for managing metals contribution SWNT toxicity. Supporting information this available WWW under...
Micron-sized particles of poorly soluble nickel compounds, but not metallic nickel, are established human and rodent carcinogens. In contrast, little is known about the toxic effects a growing number Ni-containing materials in nano-sized range. Here, we performed physicochemical characterization NiO Ni nanoparticles examined their metal ion bioavailability toxicological properties lung epithelial cells. Cellular uptake nanoparticles, microparticles, was associated with release Ni(II) ions...
Abstract This article reports a direct chemical pathway for antioxidant deactivation on the surfaces of carbon nanomaterials. In absence cells, nanotubes are shown to deplete key physiological glutathione (GSH) in reaction involving dissolved dioxygen that yields oxidized dimer, GSSG, as primary product. both and electrochemical experiments, oxygen is only consumed at significant steady‐state rate presence GSH. GSH occurs single‐ multi‐walled nanotubes, graphene oxide, nanohorns, black...
For nanotechnology to meet its potential as a game-changing and sustainable technology, it is important ensure that the engineered nanomaterials nanoenabled products gain entry marketplace are safe effective. Tools methods needed for regulatory purposes allow rapid material categorization according human health environmental risk potential, so materials of high concern can be targeted additional scrutiny, while categories pose least receive expedited review. Using carbon nanotubes an...
Significance Recent experimental studies report correlations between carbon nanotube toxicity and tube length stiffness. Very little is known, however, about the actual behavior of these fibrous nanomaterials inside living cells following uptake, fundamental mechanistic link stiffness unclear. Here we reveal a nanomechanical mechanism by which sufficiently long stiff nanotubes damage lysosomes, class membrane-enclosed organelles found that are responsible for breaking down diverse...
There has been a conceptual shift in toxicological studies from describing what happens to explaining how the adverse outcome occurs, thereby enabling deeper and improved understanding of biomolecular mechanistic profiling can inform hazard identification improve risk assessment. Compared traditional toxicology methods, which have heavy reliance on animals, new approaches generate data are becoming available for safety assessment chemicals, including high-throughput high-content screening...
Abstract The key characteristics (KC) of human carcinogens provide a uniform approach to evaluating mechanistic evidence in cancer hazard identification. Refinements the were requested by organizations and individuals applying KCs. We assembled an expert committee with knowledge carcinogenesis experience KCs leveraged this expertise examined literature more clearly describe each KC, identify current emerging assays vivo biomarkers that can be used measure them, make recommendations for...