A5085045040- Atrial Fibrillation Management and Outcomes
- Cardiac Arrhythmias and Treatments
- Cardiac pacing and defibrillation studies
- Cardiac electrophysiology and arrhythmias
- Cardiovascular Function and Risk Factors
- Health Systems, Economic Evaluations, Quality of Life
- Obstructive Sleep Apnea Research
- Alcohol Consumption and Health Effects
- Cardiac Imaging and Diagnostics
- Cardiovascular Syncope and Autonomic Disorders
- Venous Thromboembolism Diagnosis and Management
- Acute Myocardial Infarction Research
- Primary Care and Health Outcomes
- Cardiac Health and Mental Health
- Cardiac Structural Anomalies and Repair
- Takotsubo Cardiomyopathy and Associated Phenomena
- Health Policy Implementation Science
- Diet and metabolism studies
- Mental Health and Patient Involvement
- Coronary Artery Anomalies
- Mechanical Circulatory Support Devices
- Aortic Disease and Treatment Approaches
- Interprofessional Education and Collaboration
- Cardiovascular Effects of Exercise
- Cardiac, Anesthesia and Surgical Outcomes
University of Oxford
2017-2025
The Royal Melbourne Hospital
2016-2024
The University of Melbourne
2016-2024
London School of Hygiene & Tropical Medicine
2024
Austin Health
2021-2024
Northern Hospital
2024
Northern Health
2023
Austin Hospital
2014-2023
Epworth Hospital
2023
St Bartholomew's Hospital
2021
Excessive alcohol consumption is associated with incident atrial fibrillation and adverse remodeling; however, the effect of abstinence from on secondary prevention unclear.We conducted a multicenter, prospective, open-label, randomized, controlled trial at six hospitals in Australia. Adults who consumed 10 or more standard drinks (with 1 drink containing approximately 12 g pure alcohol) per week had paroxysmal persistent sinus rhythm baseline were randomly assigned 1:1 ratio to either...
Pulmonary vein isolation (PVI) alone is less effective in patients with persistent atrial fibrillation (AF) compared paroxysmal AF. The left posterior wall may contribute to maintenance of AF, and (PWI) a common PVI adjunct. However, PWI has not been subjected randomized comparison.
Background: Population studies have demonstrated a range of sex differences including higher prevalence atrial fibrillation (AF) in men and risk AF recurrence women. However, the underlying reasons for this are unknown. This study evaluated whether sex-based electrophysiological substrate exist to account worse ablation outcomes Methods: High-density electroanatomic mapping left atrium was performed 116 consecutive patients with AF. Regional analysis across 6 segments. maps were created...
Importance The impact of atrial fibrillation (AF) catheter ablation on mental health outcomes is not well understood. Objective To determine whether AF associated with greater improvements in markers psychological distress compared medical therapy alone. Design, Setting, and Participants Randomized Evaluation the Impact Catheter Ablation Psychological Distress Atrial Fibrillation (REMEDIAL) study was a randomized trial symptomatic participants conducted 2 centers Australia between June 2018...
Abstract Background and Aims Patterns of atrial fibrillation (AF) recurrence post-catheter ablation for persistent AF (PsAF) are not well described. This study aimed to describe the pattern seen following catheter PsAF implications healthcare utilization quality life (QoL). Methods was a post-hoc analysis CAPLA study, an international, multicentre that randomized patients with symptomatic pulmonary vein isolation plus posterior wall or alone. Patients underwent twice daily single lead ECG,...
Realist synthesis is a recognized methodological approach to evidence inform evidence-based health policy and practice. The implicit assumption behind research that the it generates should be generalizable––drawing broad inferences from specific observations. While this understanding generally shared among social scientists, tensions exist between having generalizable how can useful in contexts. This paper considers role of mechanism-based middle-range theories obtained realist bridging...
Inhibition of established left ventricular hypertrophy (LVH) and fibrosis may bring clinical benefits by reducing cardiac morbidity mortality. The mammalian target rapamycin, mTOR, is known to play a critical role in determining cell organ size. We investigated whether mTOR inhibition can inhibit the chronic pressure-overload-induced LVH fibrosis.Male FVB/N mice underwent transverse aortic constriction (TAC) for 5 weeks allow establishment LVH, followed treatment with inhibitor, Rapamune (2...
Obesity is associated with higher electrical cardioversion (ECV) failure in persistent atrial fibrillation (PeAF). For ease-of-use, many centers prefer patches over paddles. We assessed the optimum modality and shock vector, as well safety efficacy of Manual Pressure Augmentation (MPA) technique.Patients obesity (BMI ≥ 30) PeAF undergoing ECV using a biphasic defibrillator were randomized into one four arms by (adhesive or handheld paddles) vector (anteroposterior [AP] anteroapical [AA]). If...