Post-traumatic osteoarthritis can develop as a result of the initial mechanical impact causing injury and also chronic changes in loading joint. Aberrant initiates excessive production reactive oxygen species, oxidative damage, stress that appears to damage mitochondria surviving chondrocytes. To probe benefits increasing superoxide removal with small molecular weight dismutase mimetics under severe loads, we applied both overload scenarios bovine osteochondral explants using characterized...

Abstract Importance The indications, technology, and surgical technique for cochlear implantation have evolved over the last three decades. Understanding risk of implant revision (CIR) is important patient counseling. Objective objective this study was to analyze rates, audiologic outcomes CIR decades experience at a single academic medical center. Design A retrospective chart review performed center individuals who underwent between 1985 2022. Setting Single Participants Three thousand...

Survival outcomes for advanced non-melanoma skin cancers of the head and neck treated with surgical resection are not well described in literature. We aimed to describe T3 T4 cutaneoous squamous cell carcinoma or at 1 tertiary academic medical center.We analyzed a retrospective cohort patients diagnosed cutaneous (SCC) from 2005 2016 definitive resection. were examined using Kaplan-Meier analysis, multivariate analysis was completed Cox proportional hazard model.Forty-three met inclusion...

To study the relationship between various electrodiagnostic modalities in acute facial palsy.Academic tertiary care center.One-hundred and six patients who presented with traumatic or non-traumatic paralysis (House-Brackmann, HB, grade 6/6) 2008 2017 underwent testing.Electroneurography (ENoG) using nasolabial fold (NLF) nasalis muscle (NM) methods, volitional electromyography (EMG) all patients.Percent degeneration of ipsilateral nerve compound action potentials (CMAP) on NLF- NM-ENoG,...

Objective Cochlear implant (CI) candidacy and postoperative outcomes are assessed using sets of speech perception tests that vary from center to center, limiting comparisons across institutions time periods. The objective this study was determine if scores on one test could be reliably predicted another test. Study Design Arizona Biomedical (AzBio) Sentence Test, Consonant-Nucleus-Consonant word (CNCw), Hearing in Noise Test (HINT) quiet for the implanted ear were collected individuals who...

This Observation describes the case of a man who presented to emergency department with stridor, increased work breathing, and supplement oxygen requirement after falling an e-cigarette in his mouth several hours earlier.

Background Complication rates in many complex surgical procedures are associated with the volume of performed. Objectives To investigate relationship between hospital and complications, mortality, failure to rescue (FTR) patients undergoing vestibular schwannoma (VS) surgery. Design, Setting, Participants The Nationwide Inpatient Sample was used identify 44,336 who underwent VS surgery 1995–2011. Annual case volumes were stratified by quintiles defined as very low (≤5 cases/year), (6–12...

<b><i>Objectives:</i></b> Hypothesized causes of vestibular neuritis/labyrinthitis include neuroinflammatory or vascular disorders, yet disorders the inner ear are poorly understood. Guided by known microvascular diseases retina, we developed 2 hypotheses: (1) there exist vulnerabilities artery channels in cases hypothetical nerve swelling for superior, inferior, and vestibulocochlear (2) arteriovenous crossings that could compromise flow disease states....

The Johns Hopkins Otologic Research Laboratory was founded in 1924 as the first human temporal bone laboratory within United States. To better understand contributions of to our understanding presbycusis, we consulted with a medical librarian and archivist search Alan Mason Chesney Medical Archives, PubMed, JSTOR, Bulletin for published unpublished works from lab. Between 1938, Samuel J. Crowe, Chairman Otolaryngology, anatomist Stacy R. Guild amassed collection ∼1,800 bones. This allowed an...

Attitudes towards conflict of interest (COI) and COI policy are shaped during medical school influence both the education students their future practice. Understanding current attitudes teaching faculty may provide insight into what is taught about within ‘hidden’ curriculum. Differences between student perceptions have not been compared in detail. The authors surveyed first year at one academic center. response rate was 98.7% (150/152) for 34.2% (69/202) faculty. Students were less likely...

Background Melanin pigmentation is present within the auditory and vestibular systems of mammalian inner ear may play a role in maintaining function. Melanocytes stria vascularis (SV) are necessary for generation endocochlear potential (EP) decreased EP has been linked to age-related hearing loss. pigment-containing “dark cells” system, but have less well-defined role. African–American individuals increased SV which hypothesized be related lower rates loss dysfunction. It remains unclear if...

Objective Cochlear implant electrode arrays are categorized based on their design as lateral wall (LW) and perimodiolar (PM) arrays. The objective of this study was to investigate the effect LW versus PM designs postoperative speech perception across multiple manufacturers over long follow-up durations. Design Retrospective cohort study. Setting Single academic medical center. Participants A total 478 adult cochlear recipients, implanted between years 1992 2017. Interventions(s) implants...

To describe the features of antecedent head trauma in patients with superior canal dehiscence syndrome (SCDS).

The living human inner ear is challenging to study because it encased within dense otic capsule bone that limits access biological tissue. Traditional temporal histopathology methods rely on lengthy, expensive decalcification protocols take 9-10 months and reduce the types of tissue analysis possible due RNA degradation. There a critical need develop fresh better understand otologic diseases, such as Ménière's disease, at cellular molecular level. This paper describes technique for harvest...

Video glasses form a virtual image in front of the user. We investigated utility video at US-guided interventions.The were tested 75 consecutive interventions. The operator sees US him, and below glasses, simply by moving his eyes, he can see patient field intervention.The could be used all quality was that monitor, but adequate. working posture improved, it easy to get accustomed using system, there no increased time consumption, patients felt comfortable with set-up.Use facilitates

Background and Purpose: Prior investigations have demonstrated an inverse correlation between the interval from resection of head neck squamous cell carcinoma (HNSCC) to radiotherapy (RT) completion (overall treatment time; OTT) disease control. However, importance OTT in human papillomavirus (HPV)-associated HNSCC remains be determined. This study evaluates whether independently associated with cancer control when evaluated by HPV association. Material Methods: The data patients treated...