A5031995383- Intracranial Aneurysms: Treatment and Complications
- Brain Metastases and Treatment
- Traumatic Brain Injury and Neurovascular Disturbances
- Cerebrospinal fluid and hydrocephalus
- Vascular Malformations Diagnosis and Treatment
- Lung Cancer Research Studies
- Meningioma and schwannoma management
- Neurosurgical Procedures and Complications
- Glioma Diagnosis and Treatment
- Neurofibromatosis and Schwannoma Cases
- Facial Nerve Paralysis Treatment and Research
- Spinal Fractures and Fixation Techniques
- Inflammatory Biomarkers in Disease Prognosis
- Metabolomics and Mass Spectrometry Studies
- Cerebrovascular and Carotid Artery Diseases
- Moyamoya disease diagnosis and treatment
- Intraoperative Neuromonitoring and Anesthetic Effects
- Analytical Chemistry and Chromatography
- Intracerebral and Subarachnoid Hemorrhage Research
- Management of metastatic bone disease
- Radiopharmaceutical Chemistry and Applications
- Craniofacial Disorders and Treatments
- Liver Disease and Transplantation
- Free Radicals and Antioxidants
- Spinal Hematomas and Complications
Medical University of Vienna
2019-2025
University of Bern
1980
To evaluate the risk of tumor relapse after Simpson grade 1 resection spinal meningiomas compared to other grades. Furthermore, incidence cerebrospinal fluid (CSF) leak affected dura and use a patch for dural repair. We retrospectively analyzed consecutive series patients who underwent meningioma at our department between 1980 2020. Overall, 153 were included, 1, 2, 3 4 was achieved in 13%, 75%, 9% 3%, respectively. The median time radiological follow-up 28.5 (1-261) months. Tumor occurred...
Abstract Background Few safety data of concurrent stereotactic radiosurgery and targeted therapy (TT) or immunotherapy (IT) are available. The aim the study was to evaluate outcome melanoma patients with brain metastases (MBM) after Gamma Knife Radiosurgery (GKRS) in relation IT/TT. Methods We evaluated 182 MBM patients, who were treated GKRS modern radiosurgical oncological era. Results median time between initial diagnosis occurrence 2.4 years. overall survival 5.4 years diagnosis....
Cerebral vasospasm largely contributes to a devastating outcome after aneurysmal subarachnoid hemorrhage (aSAH), with limited therapeutic options.
The combination of Gamma Knife radiosurgery (GKRS) and systemic immunotherapy (IT) or targeted therapy (TT) is a novel treatment method for brain metastases (BMs) in non-small cell lung cancer (NSCLC). To elucidate the safety efficacy concomitant IT TT on outcome after GKRS, 496 NSCLC patients with BMs, who were treated GKRS retrospectively reviewed. median time between initial diagnosis was one month. survival BM significantly longer than predicted by prognostic scores. After first (GKRS1),...
The predictive value of the pre-radiosurgery Neutrophil-to-Lymphocyte Ratio (NLR), Platelet-to-Lymphocyte (PLR), Lymphocyte-to-Monocyte (LMR) and modified Glasgow Prognostic Score (mGPS) was assessed for first time in a homogenous group NSCLC brain metastaes (BM) patients.We retrospectively evaluated 185 NSCLC-BM patients, who were treated with Gamma Knife Radiosurgery (GKRS). Patients immunotherapy or targeted therapy excluded. Routine laboratory parameters reviewed within 14 days before...
OBJECTIVE The purpose of this study was to assess the impact temporal muscle thickness (TMT), a surrogate marker for sarcopenia, in radiosurgically treated patients with brain metastases (BMs) from non–small cell lung cancer (NSCLC). METHODS For 566 BMs NSCLC period between June 2012 and December 2019, TMT values were retrospectively measured on planning magnetic resonance imaging (MRI) studies that had been obtained before their first Gamma Knife radiosurgery treatment (GKRS1). Predefined...
Background Gamma Knife radiosurgery (GKRS) in the treatment of arteriovenous malformations (AVMs) is still controversially discussed. Objective To present long-term follow-up data on patients after for cerebral AVMs. Methods Overall, 516 received AVMs between 1992 and 2018 at our department, whom 265 alone 207 were treated with a combined endovascular-radiosurgical approach. Moreover, 45 volume-staged Two eras analyzed, pre-modern era 2002 modern thereafter. Results In GKRS-only patients,...
Complex aneurysms do not have a standard protocol for treatment. In this study, we investigate the safety and efficacy of microsurgical revascularization combined with parent artery occlusion (PAO) in giant complex internal carotid (ICA) aneurysms.Between 1998 2017, 41 patients 47 ICA were treated by an priori planned treatment strategy. Clinical radiological outcomes stratified according to mRS Raymond classification. Bypass patency was assessed. Median follow-up time 3.9 years.After...
The authors sought to evaluate clinical outcome in patients with large, high-risk brain metastases (BMs) treated different dose strategies by use of two-fraction dose-staged Gamma Knife radiosurgery (GKRS).A retrospective analysis was performed data from 142 two centers who had been GKRS between June 2015 and January 2020. Depending on the changes marginal first (GKRS1) second (GKRS2) treatments, study population divided into three treatment groups: escalation, maintenance, de-escalation.The...
We introduce TRAM, a triple acquisition strategy on high-speed, time-of-flight mass spectrometry for merging non-targeted and targeted metabolomics into one run. TRAM stands “quasi-simultaneous” of (1) full scan MS1, (2) top 30 data-dependent MS2 (DDA), (3) scheduled multiple reaction monitoring (MRM) within measurement cycles ~ 1 second. combines the selectivity sensitivity state-of-the-art MRM-based methods with scope analysis enabled by high-resolution spectrometry. In this work, we...
Abstract Objective Cranioplasty (CP) is considered as a straightforward and technically unchallenging operation; however, complication rates are high reaching up to 56%. Presence of ventriculoperitoneal shunt (VPS) timing CP reported risk factors for complications. Pressure gradients scarring at the site cranial defect seem be critical in this context. The authors present their experiences lessons learned. Methods A consecutive series all patients who underwent authors’ institution between...
Since the publication of A Randomized Trial Unruptured Brain AVMs (ARUBA), management unruptured brain arteriovenous malformations (bAVMs) has been controversially discussed. Long-term follow-up data on exclusively conservative bAVMs are scarce. The authors evaluated long-term outcomes patients with untreated in a real-life cohort.A retrospective observational cohort 107 (of 897 bAVM referred to authors' institution) diagnosis and conservatively managed is presented. all Spetzler-Martin...
Abstract Background New-onset seizures after cranioplasty (NOSAC) are reported to be a frequent complication of (CP) decompressive hemicraniectomy (DHC). There considerable differences in the incidence NOSAC and contradictory data about presumed risk factors literature. We suggest consequence patients’ initial condition which led DHC, rather than subsequent CP. conducted retrospective analysis verify our hypothesis. Methods The medical records all patients ≥ 18 years who underwent CP between...
The purpose of this study was to identify independent risk factors for incidental durotomy (ID) during decompressive lumbar spine surgery, and describe its treatment.This retrospective review includes 650 patients who underwent decompression at a tertiary institution between January 2015 October 2019. Data collection obtained through one researcher. incidence rate treatment ID evaluated by chart operative notes, patient charts, physiotherapy reports, nursing reports.The 12.6%. most common...
The objective is to provide a treatment algorithm for pediatric patients with intracranial cavernous malformations (CMs) based on our experience. Patients < 18 years of age who were treated either surgically or conservatively at the authors' institution between 1982 and 2019 retrospectively evaluated. A total 61 institution: 39 lobar CMs; deep CMs, including 12 in brainstem 6 basal ganglia; 4 CMs cerebellar hemispheres. Forty-two underwent surgery, 19 conservatively. median follow-up time...
Angiography was carried out in 27 patients with acute intestinal ischaemia. In 23 a primary, and four secondary vascular cause found. Plain films are of little value the early diagnosis mesenteric infarcts, since radiologically demonstrable changes first develop after 10 to 12 hours following incident. A definitive an infarct can only be made by angiography. Surgical intervention for proximal artery occlusion is likely successful if within hours. 80% six major occlusions five angiospastic...
Objective: Evoked potentials are widely used in comatose patients to evaluate neurological function; however, prognostic relevance after SAH is barely investigated. Therefore, we aimed investigate the value of proposed Potential Score (EPS) for somatosensory (SSEP) and brainstem auditory evoked (BAEP) on outcome poor-grade SAH. Methods: We retrospectively analyzed poor grade (Hunt Hess (HH) IV V) that were admitted ICU at Department Neurosurgery, MUV, between 2014 2017. Measurements SSEP...
Summary Objective To identify factors for tumor relapse and poor outcome in patients with meningiomas the first two decades of life. Methods All ≤ 21 years age who underwent resection a meningioma at department neurosurgery, Medical University Vienna between 1989 2022 were included this retrospective study. Clinical radiological data extracted from medical records. Outcome analyzed location, histological findings extent resection. Results In study 18 included, 6 located skull base, 5...
We introduce TRAM, a triple acquisition strategy on high-speed quadrupole time-of-flight mass spectrometer for merging non-targeted and targeted metabolomics into one run. TRAM stands "quasi-simultaneous" of (1) full scan MS1, (2) top 30 data-dependent MS2 (DDA), (3) scheduled multiple reaction monitoring (MRM) within measurement cycles ∼1 s. combines the selectivity sensitivity state-of-the-art MRM-based methods with scope analysis enabled by high-resolution spectrometry.
There is accumulating evidence that cerebrospinal fluid (CSF) concentrations of nimodipine correlate with long‐term outcome patients after subarachnoidal hemorrhage (aSAH) by impeding cerebral ischemia. However, pharmacological data on simultaneous serum vs. CSF and intraparenchymal values are rarely reported in larger patient groups. Nimodipine were determined plasma, CSF, interstitial (ISF), at steady state oral (6 × 60 mg/day) intravenous (0.5, 1, 1.5 2 mg/h) administrations 10 aSAH. Area...
So far, only limited studies exist that evaluate patients with brain metastases (BM) from GI cancer and associated primary cancers who were treated by Gamma Knife Radiosurgery (GKRS) concomitant immunotherapy (IT) or targeted therapy (TT).Survival after GKRS was compared to the general specific Graded Prognostic Assessment (GPA) Score Index for (SIR). Further, influence of age, sex, Karnofsky Performance Status Scale (KPS), extracranial (ECM) status at BM diagnosis, number BM, Recursive...
Background/Objectives: Digital subtraction angiography (DSA) is the gold standard in diagnosis of cerebral vasospasm, frequently observed after subarachnoid hemorrhage (SAH). However, less-invasive methods, such as computed tomography (CTA), may be equally accurate. To further clarify comparability, this study evaluated reliability CTA detecting vasospasm. Methods: This retrospective included 51 patients with SAH who underwent both and DSA within 24 h. The smallest diameter proximal arterial...