A5103278501- Advanced NMR Techniques and Applications
- Solid-state spectroscopy and crystallography
- Electron Spin Resonance Studies
- Spectroscopy and Quantum Chemical Studies
- Nanoparticle-Based Drug Delivery
- Photosynthetic Processes and Mechanisms
- Muon and positron interactions and applications
- Hydrogen Storage and Materials
- Curcumin's Biomedical Applications
- Thermal Expansion and Ionic Conductivity
- Advanced Battery Materials and Technologies
- Field-Flow Fractionation Techniques
Utrecht University
2021-2025
Curcumin-loaded polymeric micelles composed of poly(ethylene glycol)-b-poly(N-2-benzoyloxypropyl methacrylamide) (mPEG-b-p(HPMA-Bz)) were prepared to solubilize and improve the pharmacokinetics curcumin. by a nanoprecipitation method using mPEG5kDa-b-p(HPMA-Bz) copolymers with varying molecular weight hydrophobic block (5.2, 10.0, 17.1 kDa). At equal curcumin loading, mPEG5kDa-b-p(HPMA-Bz)17.1kDa showed better retention in both phosphate-buffered saline (PBS) plasma at 37 °C than based on...
Cellular dynamic nuclear polarization (DNP) has been an effective means of overcoming the intrinsic sensitivity limitations solid-state magnetic resonance (ssNMR) spectroscopy, thus enabling atomic-level biomolecular characterization in native environments. Achieving DNP signal enhancement relies on doping biological preparations with biradical polarizing agents (PAs). Unfortunately, PA performance within cells is often limited by their to reductive nature cellular lumen. Herein, we report...
Abstract Dynamic nuclear polarization (DNP) is a powerful method to enhance the sensitivity of solid‐state magnetic resonance (ssNMR) spectroscopy. However, its biomolecular applications at high fields (preferably>14 T) have so far been limited by intrinsically low efficiency polarizing agents and sample preparation aspects. Herein, we report new class trityl‐nitroxide biradicals, dubbed SNAPols that combine DNP with greatly enhanced hydrophilicity. SNAPol‐1, best compound in series,...
Abstract Sodium‐based complex hydrides have recently gained interest as electrolytes for all‐solid‐state batteries due to their light weight and high electrochemical stability. Although room temperature conductivities are not sufficiently battery application, nanocomposite formation with metal oxides has emerged a promising approach enhance the ionic conductivity of hydrides. This enhancement is generally attributed space charge layer at hydride‐oxide interface. However, in this study it...
In contrast to the common viewpoint that bacteriochlorophyll (BChl) motion is largely absent within chlorosome assembly, physics-based modeling points a crucial role of nanoscale librational macrocycle for transfer excitons. To elucidate this experimentally, compositional uniformity and high sensitivity are required. We focused on uniformly 13C labeled preparations from bchQ mutant Chlorobaculum tepidum with significantly enhanced structural homogeneity. The characterized using Rotational...