A5000645891- Cardiac Arrhythmias and Treatments
- Atrial Fibrillation Management and Outcomes
- Cardiac pacing and defibrillation studies
- Cardiac electrophysiology and arrhythmias
- Cardiovascular Syncope and Autonomic Disorders
- Cancer-related molecular mechanisms research
- Glioma Diagnosis and Treatment
- Head and Neck Surgical Oncology
- Medical Imaging and Analysis
- Cerebrospinal fluid and hydrocephalus
- CRISPR and Genetic Engineering
- MicroRNA in disease regulation
- Bone Tumor Diagnosis and Treatments
- Spine and Intervertebral Disc Pathology
- Neurofibromatosis and Schwannoma Cases
- Circular RNAs in diseases
- Spinal Dysraphism and Malformations
- Sarcoma Diagnosis and Treatment
- Pluripotent Stem Cells Research
- Management of metastatic bone disease
- Gene expression and cancer classification
- Cardiovascular Function and Risk Factors
- Cognitive Functions and Memory
- Memory Processes and Influences
- Intracranial Aneurysms: Treatment and Complications
Huashan Hospital
2015-2025
Fudan University
2015-2025
Shanghai Clinical Research Center
2022-2024
Shanghai Center for Brain Science and Brain-Inspired Technology
2022-2023
Beijing Institute of Neurosurgery
2022
Recent evidence has suggested that long non-coding RNAs (lncRNAs) may play a significant role in the pathogenesis of several neurological diseases, including spinal cord injury (SCI). However, little is known about lncRNAs SCI. The aim present study was to evaluate potential functions SCI and identify underlying mechanisms action. We firstly analyzed Gene Expression Omnibus (GEO) datasets investigate aberrantly-expressed which might be involved RNA X-inactive specific transcript (XIST) found...
The journal retracts the article titled “Long Coding RNA XIST Contributes to Neuronal Apoptosis through Downregulation of AKT Phosphorylation and Is Negatively Regulated by miR-494 in Rat Spinal Cord Injury” [...]
Study Design. The expression of HOXB13 and HOXA9 proteins was detected. Objective. purpose this study to investigate the molecular signature spinal ependymoma (EPN) astrocytoma, 2 most common types intramedullary tumor. Summary Background Data. Intramedullary tumor is unusual. It leads high neurological morbidity mortality without treatment. Till now, its feature has been elucidated up a little extent. Methods. A total 37 cases EPN, including 12 myxopapillary EPNs (MEPNs), 18 classic EPNs, 7...
Aberrant activation of hedgehog (Hh) signaling pathway plays an important role in the development and proliferation glioblastoma (GBM) cells.However, its mechanism remains unknown.MicroRNAs (miRNAs) are short non-coding RNA molecules which involved post-transcriptional regulation genes, enrolled transduction network tumors.This study was designed to investigate miRNAs targeting Hh GBMs.According expression level Gli1 mRNA measured by real time PCR, GBM samples were assigned high or low...
Using microarray data, the present study identified differentially expressed microRNAs (miRNAs) and evaluated their regulatory characteristics in high-grade glioma patients, with aim to further understanding into underlying etiology of condition. Previously, studies have generally implemented regression or variance analysis, which ignores various background biological factors. However, study, analysis was performed data collected from Gene Expression Omnibus database using a partial least...
Gene expression profiling facilitates the understanding of biological characteristics gliomas. Previous studies mainly used regression/variance analysis without considering various background and environmental factors. The aim this study was to investigate gene differences between grade III IV gliomas through partial least squares (PLS) based analysis. data set from Expression Omnibus database. PLS performed with R statistical software. A total 1,378 differentially expressed genes were...
Abstract Introduction Acute pulmonary vein reconnection (PVR) via epicardial fibers can be found during observation period after PV isolation, the characteristics and related factors have not been fully studied. We aimed to investigate prevalence, locations, electrogram characteristics, ablation parameters acute (AEPVR). Methods PVR was monitored isolation. AEPVRs were mapped distinguished from endocardial conduction gaps. The clinical, electrophysiological lesion set compared between...
An Isoproterenol Dependent Broad QRS Tachycardia: What is the Mechanism?Weizhuo Liu MD1, Nanqing Xiong MD2*, Wentao Gu MD21. Department of Critical Care Medicine, Shanghai Chest Hospital, Jiaotong University, 241 West Huaihai Road, 200030, China2. Cardiology, Huashan Hospital Fudan 12 Wulumuqizhong 200040, China*Corresponding author: MD, China. E-mail: huashancardio@163.comKey words: wide complex tachycardia, intermittent preexcitation, Wolff-Parkinson-White syndrome, antidromic AV reentrant...
Aberrant conduction during orthodromic reciprocating tachycardia (ORT) prolongs the ventriculoatrial time, which can be essential for maintenance of in specific cases. We searched ORT relying on aberrancy among 220 cases our center. Three patients showed phenomenon aberrancy-dependent ORT. All accessory pathways were located at lateral regions atrioventricular annulus. None them had a baseline bundle branch block (BBB). Creating functional BBB was necessary to induce tachycardias. In two...
Objective To investigate the clinical features and surgical treatment of intramedullary spinal schwannomas.Methods 8 cases iutramedullary schwannomas were respectively reviewed related data,including manifestations,imaging features,operative outcomes was analyzed.Results Tumors totally removed in all patients.During follow - up period from 3 months to 9 years,muscle strength significantly improved 5 patients with limb weakness before operation.6 complained abnormal sensitivity.No tumor...
Background. Far-field electrograms from superior vena cava (SVC) can be present in right pulmonary vein (RSPV) after (PV) isolation. Objectives. To analyze the characteristics of far-field SVC potentials RSPV PV isolation and local anatomy difference between patients with without potentials. Methods. Patients undergoing were retrospectively reviewed, contrast-enhanced computed tomography (CT) was performed before procedure for observing anatomical relationship SVC. The prevalence described...
Background Ablation of accessory pathway from the region anterolateral tricuspid annulus remains most challenging although multiple approaches have been introduced. Objective To evaluate feasibility a sequential supra-to-subvalvular approach for mapping and ablation right pathway. Methods Cases were reviewed divided into group A (conventional approach) B (sequential comparison. In B, initial radiofrequency delivery was performed in atrium along annulus, with target marked on 3D map....
Abstracts Importance Neurological function recovery after intramedullary microsurgery is susceptible to various factors. Investigating alterations in cerebrospinal fluid (CSF) protein profiles associated with spinal could provide valuable insights into prognosis and the development of postoperative therapeutic approaches. Objective The aim this research was identify CSF sets linked outcomes microsurgery. Design This an observational cohort investigation that collected data from August 2020...