A5102843986- Hearing, Cochlea, Tinnitus, Genetics
- RNA regulation and disease
- Hearing Loss and Rehabilitation
- Hearing Impairment and Communication
- Sex and Gender in Healthcare
- Asthma and respiratory diseases
- Cancer-related molecular mechanisms research
- Inclusion and Disability in Education and Sport
- RNA Research and Splicing
- Disability Education and Employment
- Assistive Technology in Communication and Mobility
- Health Systems, Economic Evaluations, Quality of Life
- Phytoplasmas and Hemiptera pathogens
- Advanced Fluorescence Microscopy Techniques
- Biochemical Analysis and Sensing Techniques
- Vestibular and auditory disorders
- Genomics and Phylogenetic Studies
- Frailty in Older Adults
- Digital Accessibility for Disabilities
- Nutrition and Health in Aging
- Noise Effects and Management
- bioluminescence and chemiluminescence research
University College London
2007-2022
King's College London
2020-2022
Gray's Inn
2021-2022
Since estrogen is thought to protect pre-menopausal women from age-related hearing loss, we investigated whether variation in estrogen-signalling genes linked status the 1958 British Birth Cohort. This analysis implicated estrogen-related receptor gamma (ESRRG) gene determining adult function and was further a total of 6134 individuals 3 independent cohorts: (i) Cohort; (ii) London ARHL case-control cohort; (iii) cohort isolated populations Italy Silk Road countries. Evidence an association...
Deafness is a highly heterogenous disorder with over 100 genes known to underlie human non-syndromic hearing impairment. However, many more remain undiscovered, particularly those involved in the most common form of deafness: adult-onset progressive loss. Despite several genome-wide association studies adult status, it remains unclear whether genetic architecture this sensory loss consists multiple rare variants each large effect size or susceptibility small medium effects. As next...
Disability is an important and often overlooked component of diversity. Individuals with disabilities bring a rare perspective to science, technology, engineering, mathematics, medicine (STEMM) because their unique experiences approaching complex issues related health disability, navigating the healthcare system, creatively solving problems unfamiliar many individuals without disabilities, managing time resources that are limited by physical or mental constraints, advocating for themselves...
Abstract Cell cycle associated protein 1 (Caprin1) is an RNA-binding that can regulate the cellular post-transcriptional response to stress. It a component of both stress granules and neuronal RNA implicated in neurodegenerative disease, synaptic plasticity long-term memory formation. Our previous work suggested Caprin1 also plays role cochlea Here, targeted inner ear-deletion mice leads early onset, progressive hearing loss. Auditory brainstem responses from -deficient show reduced...
Abstract An increasing volume of data suggests that changes in cellular metabolism have a major impact on the health tissues and organs, including auditory system where metabolic alterations are implicated both age-related noise-induced hearing loss. However, difficulty access complex cyto-architecture organ Corti has made interrogating individual states diverse cell types present challenge. Multiphoton fluorescence lifetime imaging microscopy (FLIM) allows label-free measurements...
Disability is an important and often overlooked component of diversity. Individuals with disabilities bring a rare perspective to science, technology, engineering, mathematics, medicine (STEMM) because their unique experiences approaching complex issues related health disability, navigating the healthcare system, creatively solving problems unfamiliar many individuals without disabilities, managing time resources that are limited by physical or mental constraints, advocating for themselves...
Abstract Cell cycle associated protein 1 (Caprin1) is an RNA-binding that can regulate the cellular post-transcriptional response to stress. It a component of both stress granules and neuronal RNA implicated in neurodegenerative disease, synaptic plasticity long-term memory formation. Our previous work suggested Caprin1 also plays role cochlea Here, targeted inner ear-deletion mice leads early onset, progressive hearing loss. Auditory brainstem responses from -deficient show reduced...