A5053954208- Functional Brain Connectivity Studies
- Advanced MRI Techniques and Applications
- Photoacoustic and Ultrasonic Imaging
- Cognitive Abilities and Testing
- Advanced Neuroimaging Techniques and Applications
- Dementia and Cognitive Impairment Research
- Vagus Nerve Stimulation Research
- Fetal and Pediatric Neurological Disorders
- Ultrasound and Hyperthermia Applications
- Heart Rate Variability and Autonomic Control
- Pediatric health and respiratory diseases
- Neurobiology of Language and Bilingualism
- Memory and Neural Mechanisms
- Transcranial Magnetic Stimulation Studies
- Meningioma and schwannoma management
- Genetics and Neurodevelopmental Disorders
- Parkinson's Disease Mechanisms and Treatments
- Educational Outcomes and Influences
- Glioma Diagnosis and Treatment
- Optical Imaging and Spectroscopy Techniques
- Neuroscience, Education and Cognitive Function
- Neuroscience of respiration and sleep
- HIV Research and Treatment
- Infant Health and Development
- Olfactory and Sensory Function Studies
University of California, Los Angeles
2019-2024
Neurobehavioral Systems
2020-2024
Background Low intensity, transcranial focused ultrasound (tFUS) is a re-emerging brain stimulation technique with the unique capability of reaching deep structures non-invasively. Objective/Hypothesis We sought to demonstrate that tFUS can selectively and accurately target modulate in humans important for emotional functioning as well learning memory. hypothesized would result significant longitudinal changes perfusion targeted region selective modulation BOLD activity BOLD-based functional...
Abstract Background To characterize acoustic features of an infant’s cry and use machine learning to provide objective measurement behavioral state in a cry-translator. apply the cry-translation algorithm colic hypothesizing that these cries sound painful. Methods Assessment 1000 mobile app (ChatterBaby TM ). Training by evaluating >6000 predict whether infant was due pain (vaccinations, ear-piercings), fussy, or hunger states. Using infants with reported colic. Results The 90.7% accurate...
Abstract Recent evidence suggests the aging process is accelerated by HIV. Degradation of white matter (WM) has been independently associated with HIV and healthy aging. Thus, WM may be vulnerable to joint effects Diffusion‐weighted imaging (DWI) was conducted HIV‐seropositive ( n = 72) HIV‐seronegative 34) adults. DWI data underwent tractography, which parcellated into 18 tracts interest (TOIs). Functional Analysis Diffusion Tensor Tract Statistics (FADTTS) regression assessing effect...
The amygdala is highly implicated in an array of psychiatric disorders but not accessible using currently available non-invasive neuromodulatory techniques. Low-intensity transcranial focused ultrasound (TFUS) a technique that capable reaching subcortical regions non-invasively. Healthy older adult participants (n = 21; ages 48-79) received TFUS targeting the right and left entorhinal cortex (active control region) two-visit within-participant crossover design. Before after TFUS, behavioral...
Background: This study sought to validate the clinical utility of multimodal magnetic resonance imaging (MRI) techniques in assessment neurodegenerative disorders. We intended demonstrate that advanced neuroimaging commonly used research can effectively be employed practice accurately differentiate heathy aging and dementia subtypes.Methods: Twenty patients with Alzheimer's type (DAT) 18 Parkinson's disease (PDD) were identified using gold-standard techniques. Twenty-three healthy, age sex...
Abstract Introduction Studying neuro‐structural markers of intellectual giftedness (IG) will inform scientific understanding the processes helping children excel academically. Methods Structural and diffusion‐weighted MRI was used to compare regional brain shape connectivity 12 with average high IQ 18 IG children, defined as having greater than 145. Results had larger subcortical structures more robust white matter microstructural organization between those in regions associated explicit...
Abstract Background Low-intensity transcranial focused ultrasound (tFUS) is a brain stimulation approach that holds immense promise for the treatment of brain-based disorders. Several studies in humans have shown tFUS can successfully modulate perfusion focal sonication targets including amygdala; however, limited research has explored how impacts function large-scale neural networks. Objective The aim current study was to address this gap and examine changes resting-state connectivity...
Low-intensity transcranial focused ultrasound (tFUS) is a brain stimulation approach that holds promise for the treatment of brain-based disorders. Studies in humans have shown tFUS can successfully modulate perfusion focal sonication targets, including amygdala; however, limited research has explored how impacts large-scale neural networks.
The impact of previous surgery on the assessment language dominance with preoperative fMRI remains inconclusive in patients recurrent brain tumors. Samples this retrospective study included 17 prior and 21 without (38 total; mean age 43.2, SD = 11.9; 18 females; seven left-handed). All were left dominant, as determined clinically. two samples matched 10 known confounds, including, for example, tumor laterality location (all tumors affected Brodmann areas 44/45/47). We calculated indices...