A5052326713- Chemical Synthesis and Reactions
- Multicomponent Synthesis of Heterocycles
- Chemical Synthesis and Analysis
- Synthesis and biological activity
- Cancer therapeutics and mechanisms
- Synthesis and pharmacology of benzodiazepine derivatives
- Inorganic and Organometallic Chemistry
- Oxidative Organic Chemistry Reactions
- Synthesis and Biological Evaluation
- Advanced Synthetic Organic Chemistry
- Microwave-Assisted Synthesis and Applications
- Synthesis of heterocyclic compounds
- Synthetic Organic Chemistry Methods
- Cancer Treatment and Pharmacology
- Analytical Chemistry and Chromatography
- Quinazolinone synthesis and applications
- Asymmetric Synthesis and Catalysis
- Synthesis and Reactivity of Sulfur-Containing Compounds
- Carbohydrate Chemistry and Synthesis
- Synthesis and Catalytic Reactions
- Synthesis and Characterization of Heterocyclic Compounds
- Sulfur-Based Synthesis Techniques
- Asymmetric Hydrogenation and Catalysis
- Phenothiazines and Benzothiazines Synthesis and Activities
- Chemical Reaction Mechanisms
Indian Institute of Technology Kharagpur
2025
University of Calcutta
2024
National Institute of Technology Durgapur
2023-2024
Indian Institute of Chemical Technology
2003-2020
3M (United States)
2004-2005
Yorkshire Cancer Research
2003
University of Portsmouth
1992-1999
University of Ferrara
1999
University of Greenwich
1999
Pandit Ravishankar Shukla University
1993-1996
A general and practical green chemistry route to the Biginelli cyclocondensation reaction using cerium(III) chloride as catalyst (25% mol) is described under three different sets of conditions. This method provides an efficient much improved modification original reported in 1893, terms high yields, short times, simple work-up procedure, it has ability tolerate a wide variety substitutions all components, which lacking existing procedures.
A new, mild, and efficient method has been developed for the synthesis of 2-substituted benzothiazoles via intramolecular cyclization thioformanilides by using hypervalent iodine reagents in CH2Cl2 at ambient temperature. The reaction proceeds a thiyl radical high yields to give novel compound oxybis benzothiazole is also amenable generating combinatorial libraries heterocyclic compounds solid-phase synthesis.
ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTRational design of a highly efficient irreversible DNA interstrand cross-linking agent based on the pyrrolobenzodiazepine ring systemD. Subhas Bose, Andrew S. Thompson, Jingshan Ching, John A. Hartley, Mark D. Berardini, Terence C. Jenkins, Stephen Neidle, Laurence H. Hurley, and David E. ThurstonCite this: J. Am. Chem. Soc. 1992, 114, 12, 4939–4941Publication Date (Print):June 1, 1992Publication History Published online1 May 2002Published inissue...
An efficient convergent synthesis of a homologous series C8-linked pyrrolobenzodiazepine dimers with remarkable DNA interstrand cross-linking activity and potent in vitro cytotoxicity is reported. The "amino thioacetal" cyclization procedure was used to produce the electrophilic DNA-interactive N10-C11 imine moiety during final synthetic step. In order construct key A-ring fragments (9a-d), versatile approach has been developed join two units vanillic acid alpha,omega-dihaloalkanes varying...
Several A-ring-modified analogues of the DNA-binding antitumor agent DC-81 (5) have been synthesized in order to study structure-reactivity/cytotoxicity relationships. For two molecules (23 and 30) modifications required addition a fourth ring give novel dioxolo[4,5-h]- dioxano[5,6-h]pyrrolo[2,1-c][1, 4]benzodiazepin-11-one (PBD) systems, respectively. Another three (34, 38, 48) native benzenoid A-ring replaced with pyridine, diazine, or pyrimidine rings pyrrolo[2,1-c][1,4]pyridodiazepine,...
An efficient synthesis of a homologous series C8-linked pyrrolobenzodiazepine dimers is reported; compounds with an odd number methylenes (n= 3 or 5) in the linker show higher affinity for DNA, enhanced cross-linking efficiency, and are more cytotoxic compared either n= 4 6.
A simple, efficient, and cost-effective method has been developed for the synthesis of 3,4dihydropyrimidin-2(1H)-ones by a one-pot three component cyclocondensation reaction 1,3 dicarbonyl compound, aldehyde, urea using benzyltriethylammonium chloride as catalyst, under solvent-free conditions: scope this protocol is utilized mitotic Kinesin EG5 inhibitor monastrol.
Several substituted benzothiazoles were synthesized by the intramolecular cyclization of thioformanilides using 2,6-dichloro-3,5-dicyano-1,4-benzoquinone (DDQ) in dichloromethane at ambient temperature high yields. The resulting 2-arylbenzothiazoles separated from reduced DDQ byproduct 4,5-dichloro-3,6-dihydroxyphthalonitrile treatment reaction mixture with a strongly basic ion-exchange resin. This protocol offers degree flexibility regard to functional groups that can be placed on...
An efficient and practical method has been manifested for the diversity-oriented synthesis of quinolines via Friedländer annulation reaction generation a wide range structurally interesting pharmacologically significant compounds by using ceric ammonium nitrate as catalyst (10 mol %) at ambient temperature in 45 min. A variety functional groups are introduced various positions quinoline moiety, further diversity core skeleton was expanded R1 R2 hybrids. Initial screening cytotoxicity against...
ADVERTISEMENT RETURN TO ISSUEPREVNoteNEXTReagents for Organic Synthesis: Use of Organostannyl Oxides as Catalytic Neutral Agents in the Preparation Nitriles from Primary Amides under Microwave Irradiation†D. Subhas Bose and B. JayalakshmiView Author Information Chemistry Division III, Indian Institute Chemical Technology, Hyderabad 500 007, India Cite this: J. Org. Chem. 1999, 64, 5, 1713–1714Publication Date (Web):February 10, 1999Publication History Received9 September 1998Published...
Dess-Martin periodinane (DMP), a highly versatile hypervalent iodine(V) reagent, was found to efficiently mediate the intramolecular cyclization of phenolic azomethines/Schiff bases at ambient temperature leading rapid and expeditious synthesis substituted benzoxazoles benzothiazoles. Furthermore, solution-phase strategy has been developed by treating reaction mixtures sequentially with Amberlyst A-26 thiosulfate resin diisopropylaminomethyl (PS-DIEA), which remove excess reagent byproducts,...
1-Hydroxy-1,2-benziodoxol-3(1H)-one 1-oxide (IBX) was found to be an efficient and selective reagent for the mild oxidative cleavage of C=N oximes tosylhydrazones yield their corresponding carbonyl compounds rapidly at room temperature in high yields.
Abstract: Peroxymonosulfate ion (oxone®) was found to be an efficient oxidant in the conversion of oximes carbonyl compounds.
A general and practical route for the synthesis of 3,4-dihydropyrimidin-2(1H)-ones by a one-pot condensation aldehydes, β-ketoesters, urea is described using trimethylsilyltriflate (1 mol%)-mediated cyclocondensation reaction at room temperature within 15 minutes. Yields are significantly higher than utilizing classical Biginelli conditions. Synthesis mitotic Kinesin Eg5 inhibitor monastrol has been achieved in 95% isolated yield.
The Knoevenagel condensation of carbonyl compounds with active methylene was readily carried out benzyltriethylammonium chloride as a catalytic agent, under solvent-free conditions to produce olefinic products in high yields: the scope this protocol is utilised for synthesis antibacterial agent trimethoprim.