A5103041622- Schizophrenia research and treatment
- Substance Abuse Treatment and Outcomes
- Pharmaceutical Practices and Patient Outcomes
- Mental Health Treatment and Access
- Probiotics and Fermented Foods
- Enzyme Structure and Function
- Child and Adolescent Psychosocial and Emotional Development
- Opioid Use Disorder Treatment
- Child Abuse and Trauma
- Legume Nitrogen Fixing Symbiosis
- Psychopathy, Forensic Psychiatry, Sexual Offending
- Bacteriophages and microbial interactions
- Neurotransmitter Receptor Influence on Behavior
- Salmonella and Campylobacter epidemiology
- Suicide and Self-Harm Studies
- Genomics and Phylogenetic Studies
- Prenatal Substance Exposure Effects
- Adolescent Sexual and Reproductive Health
- Personality Disorders and Psychopathology
- Glycosylation and Glycoproteins Research
- Psychiatric care and mental health services
- Protein Structure and Dynamics
University of York
2019-2022
University of Houston
2021
University of Exeter
2000
Membrane bound acyltransferase-3 (AT3) domain-containing proteins are implicated in a wide range of carbohydrate O-acyl modifications, but their mechanism action is largely unknown. O-antigen acetylation by AT3 acetyltransferases Salmonella spp. can generate specific immune response upon infection and influence bacteriophage interactions. This study integrates situ vitro functional analyses two these proteins, OafA OafB (formerly F2GtrC), which display an "AT3-SGNH fused" domain...
The acylation of sugars, most commonly via acetylation, is a widely used mechanism in bacteria that uses simple chemical modification to confer useful traits. For structures like lipopolysaccharide, capsule and peptidoglycan, function outside the cytoplasm, their during export or post-synthesis requires transport an activated acyl group across membrane. In this linked family integral membrane proteins – acyltransferase-3 (AT3). Numerous studies examining production diverse extracytoplasmic...
Adults with long-term health conditions (LTCs) are more likely to experience depressive symptoms which can worsen outcomes and quality of life, increase healthcare costs. Subthreshold depression may go undetected and/or untreated. The Community Pharmacies Mood Intervention Study (CHEMIST) explored whether community pharmacies represent a suitable setting offer brief psychological support people LTCs comorbid subthreshold depression. A feasibility intervention study nested mixed methods...
Objectives:Refine a bespoke enhanced support intervention (ESI) (including self-help materials, manual and training) for implementation by community pharmacy (CP) staff to people with sub-threshold depression long-term conditions (LTCs) based upon evidence-supported interventions in primary careDevelop refine study procedures (recruitment strategies set up, screening, participant recruitment, assessment, suitability of outcome measures data collection procedures) testing the pilot...
Background Depression is common in people with long-term health conditions, and this combination can lead to worsened outcomes increased health-care costs. Subthreshold depression, a risk factor for major prevalent population, but many remain untreated due the demand on services. The community pharmacy may be an alternative setting offer mental support; however, insufficient evidence exists support implementation. Objectives To conduct feasibility study pilot randomised controlled trial of...
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Impairments in mothers' reflective function (RF), the ability to imagine mental states of self and others, underlies maladaptive parenting strategies, which have been associated with borderline personality disorder (BPD). The current study evaluated association between mother's RF adolescents' BPD mediating role a range behaviors. Five hundred thirty-one inpatient adolescents their mothers participated study. A multimethod assessment was used alongside self-reported quality RF. Children...