A5003018141- Hibiscus Plant Research Studies
- Autophagy in Disease and Therapy
- Andrographolide Research and Applications
- Cynara cardunculus studies
- Bioactive natural compounds
- Cell death mechanisms and regulation
- Pharmacological Effects of Natural Compounds
- Phytochemicals and Antioxidant Activities
- Natural Products and Biological Research
- Chromatography in Natural Products
- Natural Antidiabetic Agents Studies
- Drug-Induced Hepatotoxicity and Protection
- Chemotherapy-induced cardiotoxicity and mitigation
- Heme Oxygenase-1 and Carbon Monoxide
- Magnolia and Illicium research
- Alcohol Consumption and Health Effects
- NF-κB Signaling Pathways
- Berberine and alkaloids research
- Phytochemistry and biological activities of Ficus species
- Genomics, phytochemicals, and oxidative stress
- Inflammasome and immune disorders
- Pomegranate: compositions and health benefits
- Cancer-related Molecular Pathways
- Traditional Chinese Medicine Analysis
- Immune Response and Inflammation
Chung Shan Medical University
2015-2025
Chung Shan Medical University Hospital
2014-2025
University of Bristol
2011
National Taiwan University of Science and Technology
2009
Chung Hwa University of Medical Technology
2008
Taichung Veterans General Hospital
2004
Protocatechuic acid (PCA) is plentiful in edible fruits and vegetables thus one anti-oxidative component of normal human diets. However, the molecular mechanisms involved chemopreventive activity PCA are poorly understood. Here, we investigated mechanism(s) underlying anti-metastatic potential PCA.We used AGS cells a wound healing model Boyden chamber assays vitro injection B16/F10 melanoma mice (metastasis vivo) to analyse effect on cancer cell invasion metastasis. The activities expression...
Hibiscus sabdariffa leaf has been previously shown to possess hypoglycemic, hypolipidemic, and antioxidant effects, induce tumor cell apoptosis. However, the molecular mechanisms involved in anticancer activity of H. extract (HLE) are poorly understood. The object study was examine anti-invasive potential HLE. First, HLE demonstrated be rich polyphenols. results wound-healing assay vitro transwell revealed that dose-dependently inhibited migration invasion human prostate cancer LNCaP (lymph...
Doxorubicin (DOX) induces oxidative stress leading to cardiotoxicity. Diosgenin, a steroidal saponin of Dioscorea opposita, has been reported have antioxidant activity. Our study was aimed find out the protective effect diosgenin against DOX-induced cardiotoxicity in mice. DOX treatment led significant decrease ratio heart weight body weight, and increases blood pressure serum levels lactate dehydrogenase (LDH), creatine phosphokinase (CPK) kinase myocardial bound (CK-MB), markers In tissue...
Andrographolide (Andro), a diterpenoid lactone isolated from traditional herbal medicine Andrographis paniculata, has been shown to suppress the growth and invasion of human colorectal carcinoma (CRC) Lovo cells, trigger apoptosis in vitro. The potential Andro as chemotherapeutic agent CRC was evaluated by investigating its cytotoxic effects single or coadministration with cisplatin (CDDP). potentiated effect CDDP cells through apoptosis. molecular mechanism for these favorable cellular...
Chronic alcohol intake leads to alcoholic fatty liver. The pathogenesis of liver is related abnormal lipid accumulation, oxidative stress, endotoxins, and cytokines. Solanum muricatum Ait. (Pepino) a plant food commonly cultivated in the Penghu island, Taiwan. Previous studies indicated that aqueous extract pepino was able attenuate diabetic progression via its antioxidative anti-inflammatory effects. However, mechanisms effects leaf preventing remain unknown. In this study, Lieber–DeCarli...
The proliferation and migration of vascular smooth muscle cells (VSMCs) are major events in the development atherosclerosis following stimulation with proinflammatory cytokines, especially tumor necrosis factor-alpha (TNF-α). Plant-derived polyphenols have attracted considerable attention prevention atherosclerosis. Hibiscus leaf has been showed to inhibit endothelial cell oxidative injury, low-density lipoprotein oxidation, foam formation. In this study, we examined anti-atherosclerotic...
Pulmonary injury is defined as a progressive inflammation. Extensive pro-inflammatory cytokines are secreted from alveolus, associated with the production of reactive oxygen species (ROS) and apoptosis. The model endotoxin lipopolysaccharide (LPS)-stimulated lung cells has been applied to mimic pulmonary injury. Some antioxidants anti-inflammatory compounds can be used chemopreventive agents Quercetin-3-glucuronide (Q3G) showed exert antioxidant, anti-inflammatory, anti-cancer, anti-aging...
Oxidized low-density lipoprotein (ox-LDL) contributes to the pathogenesis of atherosclerosis by promoting vascular endothelial cell injury. Gossypetin, a naturally occurring hexahydroxyflavone, has been shown possess antimutagenic, antioxidant, antimicrobial, and antiatherosclerotic effects. In this study, atheroprotective role gossypetin was examined in cells. The protective effect against ox-LDL-induced injury human umbilical vein cells (HUVECs) first noted at 0.1–0.5 μM. Gossypetin showed...
Metabolic syndrome (MetS) poses considerable toxicological risks due to its association with an increased likelihood of metabolic dysfunction-associated steatotic liver disease (MASLD), and is characterized by hypertension, hyperglycemia, dyslipidemia, obesity. This study aimed investigate the therapeutic potential flavonoid-rich lotus seedpod extract (LSE) in alleviating MetS MASLD-related hepatic disturbances. In vivo, mice subjected a high-fat diet (HFD) streptozotocin (STZ) injection...
AIM: Several epidemiological studies have demonstrated a close association between Helicobacter pylori (H Pylori) infection and non-cardiac carcinoma of the stomach. H induces active inflammation with neutrophilic infiltrations as well production oxygen free radicals that can cause DNA damage. The damage induced by could very harmful consequences, leading to gene modifications are potentially mutagenic and/or carcinogenic. aims present study were assess effect on expression inducible nitric...