A5102740500- Immunotherapy and Immune Responses
- Virus-based gene therapy research
- Species Distribution and Climate Change
- interferon and immune responses
- Immune Response and Inflammation
- Viral gastroenteritis research and epidemiology
- Cannabis and Cannabinoid Research
- Herpesvirus Infections and Treatments
- Monoclonal and Polyclonal Antibodies Research
- Insect and Arachnid Ecology and Behavior
- vaccines and immunoinformatics approaches
- CAR-T cell therapy research
- Religion, Spirituality, and Psychology
- Pituitary Gland Disorders and Treatments
- Thyroid and Parathyroid Surgery
- Plant and animal studies
- Viral Infections and Outbreaks Research
- HIV Research and Treatment
Utah State University
2011
Beth Israel Deaconess Medical Center
2009-2011
Harvard University
2010
Augusta University
1960
ABSTRACT The innate immune pathways that contribute to the potent immunogenicity of recombinant adenovirus (rAd) vaccine vectors remain largely undefined. Previous studies assessing immunity triggered by have focused on in vitro involving antigen-presenting cells and early vivo inflammatory responses. Here, we systematically explore Toll-like receptor (TLR) signaling requirements for generation cellular responses intramuscular immunization with common alternative serotype rAd mice....
Rare serotype and chimeric recombinant adenovirus (rAd) vectors that evade anti-Ad5 immunity are currently being evaluated as potential vaccine for human immunodeficiency virus type 1 other pathogens. We have recently reported a heterologous rAd prime-boost regimen expressing simian (SIV) Gag afforded durable partial immune control of an SIV challenge in rhesus monkeys. However, single-shot immunization may ultimately be preferable global delivery. therefore the immunogenicity protective...
Abstract Aim To investigate the phylogeographic patterns among populations of wide‐ranging velvet ant Sphaeropthalma arota to (1) examine biogeographic within this species, and (2) associate major genetic divergences historical vicariance events in order gain insight into processes that drove diversification arid‐adapted organisms. Location Western North America. Methods Phylogenetic relationships were determined by analysing two ribosomal DNA internal transcribed spacers (ITS1 ITS2) M r B...
GREENBLATT, ROBERT B. M.D.; CLARK, SARAH L. LORD, JOHN A. M.D. Author Information