A5036581765- Brucella: diagnosis, epidemiology, treatment
- Cell Adhesion Molecules Research
- Immunotherapy and Immune Responses
- Biochemical effects in animals
- Renin-Angiotensin System Studies
- Molecular Sensors and Ion Detection
- Extracellular vesicles in disease
- Burkholderia infections and melioidosis
- Respiratory and Cough-Related Research
- Ubiquitin and proteasome pathways
- RNA Interference and Gene Delivery
- Galectins and Cancer Biology
- Macrophage Migration Inhibitory Factor
- Circular RNAs in diseases
- Antimicrobial Peptides and Activities
- Sulfur Compounds in Biology
- Cardiac Valve Diseases and Treatments
- 14-3-3 protein interactions
- Calpain Protease Function and Regulation
- Asthma and respiratory diseases
- MicroRNA in disease regulation
- Coronary Interventions and Diagnostics
- Escherichia coli research studies
- Monoclonal and Polyclonal Antibodies Research
- Salmonella and Campylobacter epidemiology
Tehran University of Medical Sciences
2014-2022
Integrins are adhesion molecules which play crucial roles in cell-cell and cell-extracellular matrix interactions. Very late antigen-4 or α4β1 lymphocyte Peyer's patch molecule-1 α4β7, key factors the invasion of tumor cells metastasis. Based on previous reports, integrin α4 (ITGA4) is overexpressed some immune disorders cancers. Thus, inhibition ITGA4 could be a therapeutic strategy. In present study, miR-30a was selected order to suppress expression. The 3' UTR amplified, cloned...
In recent years, DNA methylation as a main epigenetic modification in human cancer is found promising biomarker early detection of breast cancer. Possible applications numerous hypermethylated genes have been reported diagnosis but there has little comprehensive study on the clinical usefulness these The aim present was to investigate promoter status 14-3-3 sigma gene with goal developing diagnostic application cancer.Totally 40 cases cancerous and noncancerous tissues were studied....
Blockade of α4 integrin by antibodies could be an appropriate treatment strategy in multiple sclerosis and Crohn's disease. Considering disadvantages antibodies, other elements (e.g. aptamers) have been proposed for replacement. Isolation aptamers through cell-SELEX (systematic evolution ligands exponential enrichment) method requires positive negative expressing cell lines. For a better isolation, we intended to construct line lacking specific ligand binding site integrin. Escherichia coli...
The development of protective vaccines for Brucella spp. has been hampered by the difficulty in transformation cells with foreign DNA genetic manipulation. It seems that formation spheroplasts would increase efficiency transformation. aim this study was to devise an efficient method spp.At first, spheroplast prepared glycine and ampicillin induction transformed using optimized protocols CaCl2, electroporation, lipofection methods. Then, efficacy compared between three-mentioned...
Brucella abortus vaccines help control bovine brucellosis. The RB51 strain is a live attenuated vaccine with low side effects compared other brucellosis vaccines, but it provides insufficient protective efficacy. Cell-mediated immune responses are critical in resistance against intracellular bacterial infections. Therefore, we hypothesized that the listeriolysin O (LLO) expression of Listeria monocytogenes, BAX, and SMAC apoptotic proteins could enhance efficacy safety. B. was transformed...
Introduction: Stroke is the third leading cause of death and second neurological disabilities,after alzheimer's disease in world. NaHS biological systems produce hydrogen sulfide (H2S), which will reduce damage after ischemia different tissues. According to previous studies, protects cardiomyocytes from ischemic injury. In addition, this peptide has neuroprotective effect on mouse hippocampal cultured cortical neurons. The present study was conducted determine whether provides protection...