A5098753335- Carcinogens and Genotoxicity Assessment
- Pesticide and Herbicide Environmental Studies
- SARS-CoV-2 and COVID-19 Research
- Synthesis and Biological Evaluation
- Sulfur Compounds in Biology
- Aquaculture Nutrition and Growth
- Inflammasome and immune disorders
- Science, Research, and Medicine
- Effects and risks of endocrine disrupting chemicals
- COVID-19 Clinical Research Studies
- Glutathione Transferases and Polymorphisms
Federal Service for Surveillance on Consumer Rights Protection and Human Wellbeing
2024
Engelhardt Institute of Molecular Biology
2024
Introduction. Available data indicate the SARS-CoV-2 coronavirus to be potent of impairing DNA repair processes and cause oxidative stress, which can lead accumulation damage in human cells. However, DNA-damaging effect virus has not yet been sufficiently studied. The purpose research was study ability peripheral blood lymphocytes. Materials methods. One hundred forty COVID-19 patients 24 donors control group are included study. level fragmentation lymphocytes determined by alkaline...
Abstract Here, we describe the effect of knockout (KO) two key genes ( cbs , cse ) responsible for H 2 S synthesis in transsulfuration pathway as well inactivation sulfurtransferase gene dtst1 encoding single domain rhodanese on Drosophila melanogaster genome expression and several life-history traits. The analysis production KO flies showed its minimal level strain with double CBS-/-; CSE-/- while triple CBS -/-; CSE dTST1 -/-) exhibited higher improvements lifespan. transcriptomic fly...
Introduction. Over recent decades, toxicogenetic studies have focused on the issues of genome instability under action genotoxicants, taking into account biomarkers sensitivity. The question about genotoxic potential chlorpyrifos remains open, since both positive and negative effects been revealed in various tests. aim study is investigation sensitivity donor peripheral blood lymphocytes to vitro evaluation contribution polymorphism antioxidant defense system genes (CAT (rs1001179), SOD2...
Introduction. Cyprodinil is a broad-spectrum systemic fungicide of the anilinopyrimidine class. Available literature data on genotoxicity this pesticide are contradictory. The aim work to study cytotoxic and genotoxic effects ciprodinil. Material methods. mutation activity cyprodinil was assessed in Ames test. level DNA fragmentation peripheral blood lymphocytes determined by conducting alkaline gel electrophoresis individual cells (DNA comet assay). Cell viability using TC20 cell counter...