A5036086320- Dialysis and Renal Disease Management
- Acute Kidney Injury Research
- Muscle and Compartmental Disorders
- Central Venous Catheters and Hemodialysis
- Chronic Kidney Disease and Diabetes
- Health Systems, Economic Evaluations, Quality of Life
- COVID-19 Clinical Research Studies
- Mental Health and Patient Involvement
- Urticaria and Related Conditions
- Cardiac, Anesthesia and Surgical Outcomes
- Participatory Visual Research Methods
- Physical Activity and Health
- Dermatology and Skin Diseases
- Image Processing and 3D Reconstruction
- Autoimmune Bullous Skin Diseases
- Heart Failure Treatment and Management
- Historical and Cultural Archaeology Studies
- Pancreatitis Pathology and Treatment
- Archaeology and Natural History
- Canadian Identity and History
- SARS-CoV-2 and COVID-19 Research
- Renal Diseases and Glomerulopathies
- Trauma, Hemostasis, Coagulopathy, Resuscitation
- Palliative Care and End-of-Life Issues
- Dermatologic Treatments and Research
Leicester General Hospital
2013-2024
University of Leicester
2013-2024
University Hospitals of Leicester NHS Trust
2017-2024
Leicester College
2023
National Health Service
2021
NIHR Leicester Cardiovascular Biomedical Research Unit
2021
National Institute for Health Research
2021
Glenfield Hospital
2021
University of Birmingham
2020
Katherine Hospital
2019
People with chronic kidney disease (CKD) report high levels of physical inactivity, a major modifiable risk factor for morbidity and mortality. Understanding the biological, psychosocial demographic causes activity behaviour is essential development improvement potential health interventions promotional initiatives. This study investigated prevalence inactivity determined individual correlates this in large sample patients across spectrum disease.A total 5656 people all stages CKD (1-2, 3,...
Exercise has the potential to modulate a number of complications associated with chronic kidney disease (CKD). However, typically, CKD patients lead very sedentary lifestyles, reasons for which are not fully known. The aim this qualitative study was gain an understanding motivators, barriers and beliefs held by regarding exercise.We conducted 3 focus groups 22 semi-structured interviews. Data were collected from nephrology outpatient clinics in United Kingdom. A total 36 individuals stages...
The disposal of apoptotic bodies by professional phagocytes is crucial to effective inflammation resolution. Our ability improve the impaired a limited understanding molecular mechanisms that regulate engulfment and digestion efferocytic cargo. Macrophages are necessary for liver inflammation, fibrosis, resolution, switching their phenotype from proinflammatory restorative. Using sterile injury models, we show STAT3-IL-10-IL-6 axis positive regulator macrophage efferocytosis, survival,...
Patients with chronic kidney disease frequently present elevations in markers of inflammation, a condition that appears to be exacerbated by progression and onset haemodialysis. Systemic inflammation is interlinked malnutrition muscle protein wasting implicated number morbidities including cardiovascular disease: the most common cause mortality this population. Research general population other cohorts suggests an increase habitual activity levels over prolonged period may help redress basal...
Studies exploring the relationship between time and chronic illness have generally focused on measurable aspects of time, also known as linear time. Linear follows a predictable, sequential order past, present future; measured using clock predicated normative assumptions. Sociological concepts addressing lifecourse disruption following diagnosis served to enhance understanding lived experience. To understand nuanced illness, however, requires further exploration. Here, we show how implicit...
<h3>ABSTRACT</h3> Around 3 million people in the UK have chronic kidney disease and 20% of hospital admissions are complicated by acute injury. Decline function is not a diagnosis; it essential to identify treat underlying causes either achieve recovery or slow decline function. Thorough clinical assessment simple investigations help determine category injury (pre-renal, intrinsic post-renal) inform need for biopsy, which can provide significant information evaluation suspected disease,...
Reduced physical function is associated with an increased risk of mortality among patients chronic kidney disease (CKD) not requiring renal replacement therapy (RRT). Assessments performance can help to identify those at for adverse events. However, objective measures are always feasible and self-reported may provide a suitable surrogate.We performed cohort study examining associations between walking behaviour survival in CKD RRT. Data were analysed from the QCKD (Physical activity opinions...
Here we propose the term 'biographical dialectics' as a sister to disruption' capture ongoing problem solving that characterises lives of many people living with life limiting chronic illnesses. The paper is based on experiences 35 adults end-stage kidney disease (ESKD) in receipt haemodialysis. Photovoice and semi-structured interviews showed ESKD use haemodialysis was widely agreed be biographically disruptive. In talking about showing disruption through photographs participants' universal...
There is a significant burden of cardiovascular disease morbidity and mortality in the end-stage kidney population, driven by traditional non-traditional risk factors. Despite its prevalence, heart failure difficult to diagnose dialysis population due overlapping clinical presentations, limitations investigations, impact on cardiorenal axis. ‘Foundation therapies’ are key medications which improve patient outcomes with reduced ejection fraction include beta-blockers,...
Evidence suggests extended-hours haemodialysis (HD) may improve cardiovascular, medical and quality-of-life outcomes. In-centre nocturnal (INHD) is an established but underutilized method of providing treatment. This 6-month, non-randomized controlled trial (ISRCTN16672784) recruited 13 INHD patients 12 control on conventional HD. The effects treatment left ventricular (LV) structure, function myocardial fibrosis were assessed using cardiac magnetic resonance imaging native T1 mapping....
Objectives To assess the applicability of risk factors for severe COVID-19 defined in general population patients on haemodialysis. Setting A retrospective cross-sectional study performed across thirty four haemodialysis units midlands UK. Participants All 274 maintenance who tested positive SARS-CoV-2 PCR testing between March and August 2020, participating centres. Exposure The utility obesity, diabetes status, ethnicity, Charlson Comorbidity Index (CCI) socioeconomic deprivation scores...
Purpose of review There is an excess cardiovascular morbidity and mortality in the maintenance haemodialysis population. Targeting traditional risk factors (e.g. hypercholesterolaemia) do not improve outcomes. Repeated myocardial stunning during important nontraditional risk, resulting pathological cardiac remodelling fibrosis. This explores dialysate cooling as a management strategy to promote haemodynamic stability, reduce injury, disease outcomes for individuals receiving haemodialysis....
Haemodialysis is a common treatment option offered internationally for people requiring kidney replacement therapy. Research exploring haemodialysis predominantly clinical and quantitative, improvements to its provision receipt tends also be clinically focused. In recent years, however, number of studies have sought explore the lived experience haemodialysis. These tend use semi-structured interviews present descriptive findings. Such findings serve raise profile patient perspectives...
Abstract Introduction End‐stage kidney disease causes significant morbidity, mortality, and reduced quality of life. Despite improvements in conventional hemodialysis, these problems persist. In‐center nocturnal hemodialysis (INHD) has been shown to be beneficial observational studies. This report outlines a 4‐year renal network experience INHD from the patient frontline staff perspective. Methods Staff patients' experiences were evaluated through two work streams. Work stream one: 12...
Abstract Background In-centre nocturnal haemodialysis (INHD) offers extended-hours haemodialysis, 6 to 8 h thrice-weekly overnight, with the support of dialysis specialist nurses. There is increasing observational data demonstrating potential benefits INHD on health-related quality life (HRQoL). a lack randomised controlled trial (RCT) confirm these and assess safety. Methods The NightLife study pragmatic, two-arm, multicentre RCT comparing impact months conventional (thrice-weekly daytime...
The haemodialysis (HD) population is sedentary, with substantial cardiovascular disease risk. In the general population, small increases in daily step count associate significant reductions mortality. This study explores relationship between and surrogate markers of disease, including left ventricular ejection fraction (LVEF) native T1 (a marker diffuse myocardial fibrosis), within HD population.