A5103052095- Advancements in Transdermal Drug Delivery
- Genetic Mapping and Diversity in Plants and Animals
- Toxin Mechanisms and Immunotoxins
- Monoclonal and Polyclonal Antibodies Research
- Genetics and Plant Breeding
- Telomeres, Telomerase, and Senescence
- Legume Nitrogen Fixing Symbiosis
- Ginseng Biological Effects and Applications
- Plant Diversity and Evolution
- Morphological variations and asymmetry
- Cassava research and cyanide
- Plant and Fungal Species Descriptions
- Dermatology and Skin Diseases
- Genomics and Phylogenetic Studies
- Epigenetics and DNA Methylation
- Optical measurement and interference techniques
- Plant Molecular Biology Research
- Image Processing Techniques and Applications
- Chromosomal and Genetic Variations
- Cancer Genomics and Diagnostics
- RNA and protein synthesis mechanisms
- Bacteriophages and microbial interactions
- Cannabis and Cannabinoid Research
- Topological and Geometric Data Analysis
- Photosynthetic Processes and Mechanisms
Beijing University of Agriculture
2024
Institute of Botany
2014-2023
Chinese Academy of Sciences
2013-2023
Technical Institute of Physics and Chemistry
2023
Shanghai Institute of Nutrition and Health
2020
Shanghai Institutes for Biological Sciences
2020
Technology and Engineering Center for Space Utilization
2020
Kunming Institute of Zoology
2013
Universal conventional DNA barcodes will become more and popular in biological material identifications. However, many cases such as processed medicines or canned food, the universal are unnecessary and/or inapplicable due to degradation. mini-barcode is a solution for specific purposes. Here we exemplify how develop best mini-barcodes taxa using ginseng genus (Panax) an example. The chloroplast genome of P. notoginseng was sequenced. compared with that ginseng. Regions highest variability...
Abstract DNA methylation is a ubiquitous chromatin feature, present in 25% of cytosines the maize genome, but variation and evolution landscape during domestication remain largely unknown. Here, we leverage whole-genome sequencing (WGS) bisulfite (WGBS) data on populations modern maize, landrace, teosinte ( Zea mays ssp. parviglumis) to estimate epimutation rates selection coefficients. We find weak evidence for direct any context, thousands differentially methylated regions (DMRs) are...
Purpose: Transdermal Drug Delivery System (TDDS) offers a promising alternative for delivering poorly soluble drugs, challenged by the stratum corneum's barrier effect, which restricts pool of drug candidates suitable TDDS. This study aims to establish delivery platform specifically highly lipophilic drugs requiring high doses (log P > 5, dose 10 mg/kg/d), improve their intradermal and enhance solubility. Methods: Cannabidiol (CBD, log = 5.91) served as model drug. A CBD nanosuspension...
Bacteriophages, the viruses of eubacteria, have developed unique mechanisms to interact with their host bacteria. They been viewed as potential antibacterial therapeutics. Mycobacteriophage-derived compounds may Mycobacterium tuberculosis (MTB) and/or its components, such cord factor, trehalose-6,6'-dimycolate (TDM), which is most abundant glycolipid produced on surface MTB. TDM emulsion injected intravenously into mice induces lung immunopathology that mimics many aspects MTB infection....
Common purslane (Portulaca oleracea) integrates both C4 and crassulacean acid metabolism (CAM) photosynthesis pathways is a promising model plant to explore C4-CAM plasticity. Here, we report high-quality chromosome-level genome of nicotinamide adenine dinucleotide (NAD)-malic enzyme (ME) subtype common that provides evidence for 2 rounds whole-genome duplication (WGD) with an ancient WGD (P-β) in the ancestor Portulacaceae Cactaceae around 66.30 million years ago (Mya) another (Po-α)...
Abstract Hybrid plants are found extensively in the wild, and they often demonstrate superior performance of complex traits over their parents other selfing plants. This phenomenon, known as heterosis, has been applied plant breeding for decades. However, process decoding hybrid genomes seriously lagged due to challenges associated with genome assembly lack appropriate methodologies subsequent representation analysis. Here, we present analysis 2 hybrids, an intraspecific between maize (Zea...
Real-time state estimation is critical in rapidly assessing structural health to empower real-time feedback mitigation strategies. Of interest this paper the of high-rate system dynamics. High-rate systems are defined as dynamic experiencing (< 100 ms) and high-amplitude (acceleration > gn) events. Examples include hypersonic vehicles active impact The advanced operation these mechanisms can only be achieved through control capable operating sub-millisecond range, thus necessitating...
Abstract Cellular senescence restrains the expansion of neoplastic cells through several layers regulation, including epigenetic decoration chromatin structure and functional modulation bioactive components. Here we report that expression histone H3-specific demethylase KDM4 is upregulated in human stromal upon cellular senescence. In clinical oncology, diminished H3K9/H3K36 methylation are correlated with adverse survival cancer patients post-chemotherapy. Global accessibility mapping via...