A5071066502- melanin and skin pigmentation
- Ion Channels and Receptors
- Connexins and lens biology
- Skin Protection and Aging
- Biochemical Analysis and Sensing Techniques
- Bioactive Compounds and Antitumor Agents
First Affiliated Hospital of Dalian Medical University
2020-2022
Dalian Medical University
2020-2022
Abstract Melanocytes stimulated by ultraviolet radiation (UVR) produce melanin and melanosomes, which causes skin pigmentation acts as an important physiological defence process for photoprotection. Neutral luminal pH of melanosomes is critical providing optimal conditions the rate‐limiting, pH‐sensitive synthesizing enzyme tyrosinase (TYR). As a major component extraocular phototransduction pathway, transient receptor potential ankyrin1 (TRPA1) can be activated B (UVB) reported to expressed...
Vitiligo is an acquired pigmentary disorder resulting from selective destruction of melanocytes. Emerging studies have suggested that T helper cell 17 (Th17) potentially implicated in vitiligo development and progression. It was recently discovered metabotropic glutamate receptor 4 (mGluR4) can modulate Th17-mediated adaptive immunity. However, the influence mGluR4 on melanogenesis melanocytes has yet to be elucidated. In present study, we primarily cultured mouse bone marrow-derived...
Ultraviolet radiation (UVR) enhances skin pigmentation, which involves the production of melanin by melanocytes and subsequent transfer to keratinocytes. In epidermis, keratinocyte phagocytosis plays a pivotal role in process melanosome protect DNA epidermal cells against damage from UVR. Previous research suggested that transient receptor potential channels ankyrin 1 (TRPA1) was required for UVR-induced early synthesis melanocytes. Currently, there is no evidence supports detailed mechanism...