A5056978779- Inflammasome and immune disorders
- Cancer, Lipids, and Metabolism
- Cancer Research and Treatments
- Cancer Cells and Metastasis
- Metabolism, Diabetes, and Cancer
- RNA modifications and cancer
- Esophageal Cancer Research and Treatment
- Mesenchymal stem cell research
- Escherichia coli research studies
- CAR-T cell therapy research
- Toxoplasma gondii Research Studies
- Gout, Hyperuricemia, Uric Acid
- Drug Transport and Resistance Mechanisms
- Peroxisome Proliferator-Activated Receptors
- Cancer-related gene regulation
- Neutrophil, Myeloperoxidase and Oxidative Mechanisms
- Cancer-related molecular mechanisms research
National Institute of Biological Sciences, Beijing
2020-2023
Anhui University of Traditional Chinese Medicine
2021-2022
Sun Yat-sen University
2020
Chinese Academy of Medical Sciences & Peking Union Medical College
1988
Cytotoxic lymphocyte-mediated immunity relies on granzymes. Granzymes are thought to kill target cells by inducing apoptosis, although the underlying mechanisms not fully understood. Here, we report that natural killer and cytotoxic T lymphocytes gasdermin B (GSDMB)-positive through pyroptosis, a form of proinflammatory cell death executed family pore-forming proteins. Killing results from cleavage GSDMB lymphocyte-derived granzyme A (GZMA), which unleashes its activity. Interferon-γ (IFN-γ)...
Taurochenodeoxycholic acid (TCDCA) is the principal ingredient of Compound Shougong Powder. Despite traditional Chinese medicine (TCM) research demonstrates that Powder can restrict tumor growth, whether TCDCA exerts a role in suppressing cancer as major remains unknown. This study aims to clarify regulatory mechanism on gastric cancer. Gastric cells SGC-7901 were cultured investigate effects proliferation and apoptosis. Furthermore, subcutaneously implanted model was established using...
Abstract Background This study aimed to determine the effect of type 2 diabetes mellitus (T2DM) on overall survival (OS) patients with stage IIIB–IV non‐small cell lung cancer (NSCLC). Methods We retrospectively analyzed NSCLC from January 2015 December 2018 in Department Oncology at First Affiliated Hospital Anhui University Traditional Chinese Medicine. Kaplan–Meier plots, log‐rank tests, and Cox proportional hazards regression models were used describe T2DM OS NSCLC. Results collected...