A5064989667- Visual perception and processing mechanisms
- Ophthalmology and Visual Impairment Studies
- Ophthalmology and Eye Disorders
- Vestibular and auditory disorders
- Glaucoma and retinal disorders
- Tactile and Sensory Interactions
- Motor Control and Adaptation
- Multisensory perception and integration
- Circadian rhythm and melatonin
- Retinal Development and Disorders
- Cerebral Venous Sinus Thrombosis
- Olfactory and Sensory Function Studies
- Mindfulness and Compassion Interventions
- Intraocular Surgery and Lenses
- Ophthalmology and Visual Health Research
- Spatial Neglect and Hemispheric Dysfunction
- Botulinum Toxin and Related Neurological Disorders
- Skin Protection and Aging
- Migraine and Headache Studies
- Cerebrospinal fluid and hydrocephalus
- Retinal Diseases and Treatments
- Ocular and Laser Science Research
- Diversity and Career in Medicine
- Spaceflight effects on biology
- Facial Nerve Paralysis Treatment and Research
University of Toronto
2015-2024
Hospital for Sick Children
2015-2024
St. Michael's Hospital
2024
Public Health Ontario
2019-2024
SickKids Foundation
2013-2023
New York University
2022
Canada Research Chairs
2022
Toronto Western Hospital
1998-2020
Krembil Research Institute
2017-2020
Great Ormond Street Hospital
2010-2020
We investigated whether the sensory impairments of amblyopia are associated with a decrease in eye position stability (PS).The positions both eyes were recorded simultaneously three viewing conditions: binocular, monocular fellow (right for controls), and amblyopic (left controls). For conditions, movements covered also (open-loop testing). Bivariate contour ellipses (BCEAs), representing region over which found 68.2% time, calculated normalized by log transformation.For controls, there no...
Purpose.: Impairment of spatiotemporal visual processing is the hallmark amblyopia, but its effects on eye movements during visuomotor tasks have rarely been studied. Here authors investigate how deficits in anisometropic amblyopia affect saccadic movements. Methods.: Thirteen patients with and 13 control subjects participated. Participants executed saccades manual reaching to a target presented randomly 5° or 10° left right fixation three viewing conditions: binocular, amblyopic, fellow...
Neuronal ceroid lipofuscinoses (NCLs; Batten disease) are collectively the most frequent autosomal-recessive neurodegenerative disease of childhood, but underlying cellular and molecular mechanisms remain unclear.Several lines evidence have highlighted important role that non-somatic compartments neurons (axons synapses) play in instigation progression NCL pathogenesis.Here, we report a progressive breakdown axons synapses brains two different mouse models NCL: Ppt1 2/2 model infantile Cln6...
Vision plays an important role in controlling posture and balance children. Reduced postural control has been reported children with strabismus, but little specifically amblyopia.To investigate whether amblyopia have reduced compared to both strabismus without healthy controls.In this cross-sectional study, a total of 56 patients controls were recruited from the Ophthalmology Otolaryngology Clinics at The Hospital for Sick Children, Toronto. Participants divided into three groups: (1) 18...
The effects of impaired spatiotemporal vision in amblyopia on visuomotor skills have rarely been explored detail. goal this study was to examine the influences visually guided reaching.Fourteen patients with anisometropic and 14 control subjects were recruited. Participants executed reach-to-touch movements toward targets presented randomly 5° or 10° left right central fixation three viewing conditions: binocular, monocular amblyopic eye, fellow eye (left for subjects). Visual feedback...
It has previously been shown that anisometropic amblyopia affects the programming and execution of saccades. The aim current study was to investigate impact strabismic on saccade performance.Fourteen adults with amblyopia, 13 strabismus without 14 visually normal performed saccades reach-to-touch movements targets presented at ± 5° 10° eccentricity during binocular monocular viewing. Latency, amplitude, peak velocity primary secondary were measured.In contrast participants who had shorter...
To examine the effects of anisometropic amblyopia on temporal pattern eye-hand coordination during visually-guided reaching.Eighteen patients with and 18 control subjects were recruited. Participants executed reach-to-touch movements toward visual targets under three viewing conditions: binocular, monocular amblyopic eye, fellow eye viewing. Temporal between hand was examined reach planning (interval initiation saccade reaching) execution peak velocity). The frequency dynamics secondary...
To examine the effects of impaired spatiotemporal vision on reaching movements in participants with strabismic amblyopia and to compare their performance those strabismus only without visually normal participants.Sixteen adults amblyopia, 14 only, 16 were recruited. Participants executed reach-to-touch toward targets presented randomly 5° or 10° left right central fixation three viewing conditions: both eyes, monocular amblyopic eye (nondominant for amblyopia), fellow (dominant amblyopia)....
We previously showed that anisometropic amblyopia affects the programming and execution of saccades reaching movements. In our current study, we investigated whether these amblyopia-related changes simply are due to a reduction in visual acuity alone by inducing artificial blur one eye visually-normal participants.Twelve participants performed reach-to-touch movements targets presented on computer screen during binocular monocular viewing. A contact lens was used vision mean level 20/50....
Purpose.: The postillumination pupil response (PIPR) is produced by intrinsically photosensitive retinal ganglion cells (ipRGCs). We aimed to refine the testing conditions for PIPR investigating whether a greater can be induced using full-field light stimuli of shorter duration and lower intensity than that existing protocols use central-field stimuli. Methods.: Pupil was recorded with an eye tracker in 10 visually-normal subjects. Red blue were presented Ganzfeld system. In Experiment 1...
To evaluate the efficacy and safety of fluoroscopic-guided repositioning peritoneal dialysis (PD) catheter using guidewire manipulation in our center Hong Kong. All patients underwent PD institution between November 1, 2017 to December 31, 2022 were reviewed. Patients fulfilling selection criteria identified, with their clinical notes, relevant radiological reports, interventional images, operative records retrospectively The success rate was evaluated, technical defined as improved free...
Objective: To determine the sensitivity and specificity of a new upright-supine test to differentiate skew deviation from trochlear nerve palsy other causes vertical strabismus in large number patients. Methods:The study consisted 125 consecutive patients who sought treatment January 1, 2008, through December 31, 2010, for various causes: (25 patients), (58 restrictive (14 (eg, myasthenia gravis childhood strabismus) (28 patients).Twenty healthy participants served as controls.The was...
Impairment of spatiotemporal visual processing in amblyopia has been studied extensively, but its effects on visuomotor tasks have rarely examined. Here, we investigate how deficits affect motor planning and online control visually-guided, unconstrained reaching movements.Thirteen patients with mild amblyopia, 13 severe visually-normal participants were recruited. Participants reached touched a target during binocular monocular viewing. Motor was assessed by examining spatial variability the...