ABSTRACT Purpose Hypomagnesemia associated with proton pump inhibitor (PPI) therapy has been documented in case reports. We performed a cross‐sectional study to examine the association between PPI use and serum magnesium (Mg) levels or hypomagnesemia. Methods Data were extracted from hospitalized adults basic metabolic panels and/or available during hospital stays. The first Mg value was used for data analysis. is defined as less than 1.7 mg/dL (or 0.70 mmol/L). Multiple linear logistic...

Abstract Concurrent hemolysis in patients with vitamin B12 deficiency is a well-recognized phenomenon and has been attributed to intramedullary destruction of erythrocytes (ineffective erythropoiesis). Recent studies revealed that homocysteine increased the risk vitro there high frequency (30%) asymptomatic homozygous methylene tetrahydrofolate reductase (MTHFR) C677T mutation, known cause hyperhomocysteinemia. Here we report three MTHFR mutations presenting hemolytic anemia severely...

Proton pump inhibitor (PPI) may suppress adrenal cortical steroid synthesis and release, thereby leading to electrolyte disturbances. Both hyponatremia hyperkalemia in the setting of PPI therapy have been documented case reports. The objective this study was examine association between serum potassium (K(+)) level use.A retrospective data analysis hospitalized adults aged > or = 65 years during 2006, including users (N 257) non-users 388), conducted. Multiple linear logistic regression...

Subclinical features of zinc deficiency can be challenging to recognize. The prevalence based on blood concentration in an adult outpatient clinic setting has not been well-studied.To estimate the low serum concentrations among community-dwelling adults, and characterize clinical risk factors associated with deficiency.This retrospective pilot study took place from 2014 2017 at southeast Ohio. Patients aged 50 years or older a stable health status were categorized into case group (serum...

Abstract Background Serum zinc (Zn) levels have been shown to be associated with functional status; however, it is not clear whether this association differs by other sociodemographic characteristics. We examined the between serum Zn and physical functioning difficulty in a representative sample of older adults US. Design methods A cross-sectional study was conducted on participants 50 years from 2011–12 2013–14 National Health Nutrition Examination Surveys ( n = 1136). were analyzed as...

ABSTRACT Aim The concept of metabolically healthy obesity (MHO) has not been studied in type 1 diabetes (T1D). By analysing datasets from the DCCT/EDIC study, we compared development diabetic complications by and metabolic health over 30 years follow up. Materials Methods Insulin resistance was calculated estimated glucose disposal rate (eGDR). participants ( n = 1127) were then divided into four groups based on time‐weighted mean body mass index eGDR: non‐obesity (MHN, 874), unhealthy (MUN,...

Aging may affect ascending colon (AC) differently from descending (DC) and increase the risk of fecal loading (FL) in AC.

Abstract Endotoxin-responsive (C3H/HeN) and -hyporesponsive (C3H/HeJ) murine Blymphocytes purified by adherence to anti-immunoglobulin (“antibodypanning”) possess identical gangliosides but different gangliosidesurface accessibilities. We investigated the distribution surfaceaccessibility of B lymphocytes toplastic (“plastic panning”) or subtraction non-B-lymphocytecomponents. As with antibody panning, there were no entirely new orabsent in plastic-panned subtraction-purified each strain....

Abstract Pyoderma gangrenosum (PG) is a rare but serious neutrophilic dermatosis characterized by ulcerative lesions with violaceous borders. The disease mainly occurs in young or middle-aged adults. authors present the case of 79-year-old female nursing home patient who had an idiopathic PG-like ulcer on her lower extremity. Initial treatment 3 courses antibiotics and topical wound care for assumed cellulitis failed to improve lesion, healed rapidly after 1-week course prednisone therapy...