A5032770052- Metal complexes synthesis and properties
- Porphyrin and Phthalocyanine Chemistry
- Nanoplatforms for cancer theranostics
- Ferrocene Chemistry and Applications
- DNA and Nucleic Acid Chemistry
- Photodynamic Therapy Research Studies
- Metal-Catalyzed Oxygenation Mechanisms
- Advanced biosensing and bioanalysis techniques
- Magnetism in coordination complexes
- Synthesis and Biological Evaluation
- Molecular Sensors and Ion Detection
- Crystallization and Solubility Studies
- Heme Oxygenase-1 and Carbon Monoxide
- X-ray Diffraction in Crystallography
- Computational Drug Discovery Methods
- Synthesis and Characterization of Heterocyclic Compounds
- COVID-19 Clinical Research Studies
- Luminescence and Fluorescent Materials
- Click Chemistry and Applications
- Lanthanide and Transition Metal Complexes
- SARS-CoV-2 and COVID-19 Research
- Vanadium and Halogenation Chemistry
- Organoselenium and organotellurium chemistry
- RNA modifications and cancer
- Free Radicals and Antioxidants
National Institute of Technology Agartala
2024-2025
National Institute of Technology Manipur
2016-2025
KPC Medical College and Hospital
2020
Indian Institute of Science Bangalore
2007-2019
Bangalore University
2011-2019
Christian Medical College & Hospital
2011
Christian Medical College
2011
Ferrocene-conjugated l-tryptophan (l-Trp) reduced Schiff base (Fc-TrpH) copper(II) complexes [Cu(Fc-Trp)(L)](ClO4) of phenanthroline bases (L), viz. 2,2′-bipyridine (bpy in 1), 1,10-phenanthroline (phen 2), dipyrido[3,2-d:2′,3′-f]quinoxaline (dpq 3), and dipyrido[3,2-a:2′,3′-c]phenazine (dppz 4), were prepared characterized their photocytotoxicity studied. Cationic (Ph-TrpH) [Cu(Ph-Trp)(L)(H2O)](ClO4) (L = phen 5; dppz 6) having the ferrocenyl moiety replaced by a phenyl group Zn(II)...
We report the anticancer activity of a red light-activable hetero-bimetallic [Fe(iii)–Ru(ii)] complex as next-generation dual-modality PDT tool for photo-activated therapy.
Ternary iron(III) complexes [FeL(B)] (1−3) of a trianionic tetradentate phenolate-based ligand (L) and phenanthroline base (B), namely, 1,10-phenanthroline (phen, 1), dipyridoquinoxaline (dpq, 2), dipyridophenazine (dppz, 3), have been prepared structurally characterized their DNA binding, cleavage, photocytotoxic properties studied. The with FeN3O3 core show the Fe(III)/Fe(II) redox couple near −0.6 V in DMF, magnetic moment value ∼5.9 μB, binding propensity to both calf thymus bovine serum...
Ferrocene-appended copper(II) complexes [Cu(Fc-tpy)(B)](ClO4)2 (1−3) and [Cu(Ph-tpy)(dppz)](ClO4)2 (4) as control, where Fc-tpy is 4′-ferrocenyl-2,2′:6′,2′′-terpyridine, Ph-tpy 4′-phenyl-2,2′:6′,2′′-terpyridine, B a phenanthroline base, viz., 1,10-phenanthroline (phen, 1), dipyridoquinoxaline (dpq, 2), dipyridophenazine (dppz, 3), were prepared structurally characterized, their DNA binding, photoactivated cleavage activity, cytotoxic properties studied [Fc = (η5-C5H4)FeII(η5-C5H5)]....
Ferrocene-conjugated ternary copper(II) complexes [Cu(L)(B)](ClO4)2, where L is FcCH2N(CH2Py)2 (Fc = (η5-C5H4)FeII(η5-C5H5)) and B a phenanthroline base, viz., 2,2′-bipyridine (bpy, 1), 1,10-phenanthroline (phen, 2), dipyrido[3,2-d:2′,3′-f]quinoxaline (dpq, 3), dipyrido[3,2-a:2′,3′-c]phenazine (dppz, 4), have been synthesized characterized by various spectroscopic analytical techniques. The bpy complex 1, as its hexafluorophosphate salt, has structurally X-ray crystallography. molecular...
Ferrocene-conjugated reduced Schiff base (Fc-metH) copper(II) complexes of l-methionine and phenanthroline bases, namely, [Cu(Fc-met)(B)](NO3), where B is 1,10-phenanthroline (phen in 1), dipyrido[3,2-d:2′,3′-f]quinoxaline (dpq 2), dipyrido[3,2-a:2′,3′-c]phenazine (dppz 3), 2-(naphthalen-1-yl)-1H-imidazo[4,5-f][1,10]phenanthroline (nip 4), were prepared characterized their photocytotoxicity studied (Fc = ferrocenyl moiety). Complexes [Cu(Ph-met)(B)](NO3) the from benzaldehyde (Ph-metH) 5,...
Iron(III) complexes [FeL(B)] (1−5) of a tetradentate trianionic phenolate-based ligand (L) and modified dipyridophenazine bases (B), namely, dipyrido-6,7,8,9-tetrahydrophenazine (dpqC in 1), dipyrido[3,2-a:2′,3′-c]phenazine-2-carboxylic acid (dppzc 2), dipyrido[3,2-a:2′,3′-c]phenazine-11-sulfonic (dppzs 3), 7-aminodipyrido[3,2-a:2′,3′-c]phenazine (dppza 4) benzo[i]dipyrido[3,2-a:2′,3′-c]phenazine (dppn 5), have been synthesized their photocytotoxic properties studied along with analogue (6)....
Screening of selected transition metal-based antiviral agents,<italic>in silico</italic>, predicted the potential inhibition RNA-dependent RNA polymerase (RdRp) SARS-CoV-2 which emerged as drug candidate for COVID-19.
A new ternary iron(III) complex [FeL(dpq)] containing dipyridoquinoxaline (dpq) and 2,2-bis(3,5-di-tert-butyl-2-hydroxybenzyl)aminoacetic acid (H3L) is prepared structurally characterized by X-ray crystallography. The high-spin with a FeN3O3 core shows quasi-reversible iron(III)/iron(II) redox couple at -0.62 V (vs SCE) in DMF/0.1 M TBAP broad visible band 470 nm DMF/Tris buffer. Laser photoexcitation of this phenolate (L)-to-iron(III) charge-transfer wavelengths including red light >or=630...
Dipyridoquinoxaline (dpq) complexes of bivalent 3d-metal ions, viz., [FeII(dpq)3](PF6)2 (1), [CoII(dpq)3](ClO4)2 (2), [NiII(dpq)3](ClO4)2 (3), [CuII(dpq)2(H2O)](ClO4)2 (4), [ZnII(dpq)3](ClO4)2 (5), and [ZnII(dpq)2(DMF)2](ClO4)2 (5a) (DMF = N,N-dimethylformamide), are prepared their photoinduced DNA cleavage activity studied. Structural characterization for the 1 5a is done by single-crystal X-ray crystallography. All show efficient binding propensity to calf thymus with a constant (K) value...
Three oxo-bridged diiron(III) complexes of L-histidine and heterocyclic bases [Fe2(μ-O)(L-his)2(B)2](ClO4)2 (1–3), where B is 2,2′-bipyridine (bpy), 1,10-phenanthroline (phen), dipyrido[3,2-d:2′,3′-f]quinoxaline (dpq), were prepared characterized. The bpy complex 1 was structurally characterized by X- ray crystallography. molecular structure showed a {Fe2(μ-O)} core in which iron(III) FeN4O2 coordination bound to tridentate monoanionic bidentate ligands. Fe⋯Fe distance ∼3.5 Å. Fe–O–Fe unit...
Ferrocene-appended ternary copper(II) complexes of phenanthroline bases having CuN3OS coordination with an axial Cu−S bond derived from l-methionine reduced Schiff base shows red light induced oxidative DNA cleavage activity following a hydroxyl radical pathway. The dipyridophenazine complex, in addition, displays photoinduced bovine serum albumin protein UV-A light.
Water soluble cationic imidazopyridine species (<bold>1</bold>) having metal binding sites induces metal-assisted caspase dependent apoptosis in cancer cells and enhanced photodynamic effect the presence of Fe<sup>2+</sup>or Zn<sup>2+</sup>ions.
Improved ISC in La(<sc>iii</sc>) complex of curcumin, on activation with visible light, has resulted high yield <sup>1</sup>O<sub>2</sub> HeLa/MCF-7 cells, leading to the oxidative stress which was responsible for remarkable caspase 3/7-dependent apoptotic photocytotoxicity.
New iron( iii )-phenolate/carboxylate complex-functionalized selenium nanowires (Fe@SeNWs) were synthesized, which have emerged as strategic tools for next generation chemo-phototherapeutic applications.
Four (mu-oxo)diiron(iii) complexes [Fe(2)(mu-O)(H(2)O)(2)B(4)](ClO(4))(4) ( and ) [Fe(2)(mu-O)(mu-O(2)CMe)B(4)](ClO(4))(3) ), where B = 1,10-phenanthroline (phen) dipyrido[3,2-d:2',3'-f]quinoxaline (dpq), are prepared their DNA binding cleavage activity studied. The show propensity giving K(b) values of 3.6-9.3 x 10(4) M(-1). viscosity melting data suggest a surface and/or groove nature the to calf thymus (CT) DNA. obtained from isothermal calorimetric study indicate two modes involving...