A5034643585- Pancreatic and Hepatic Oncology Research
- Gastric Cancer Management and Outcomes
- CAR-T cell therapy research
- Phagocytosis and Immune Regulation
- Retinal and Optic Conditions
- Hepatocellular Carcinoma Treatment and Prognosis
- Liver Disease Diagnosis and Treatment
- RNA modifications and cancer
- Topic Modeling
- Neuroendocrine Tumor Research Advances
- Cholangiocarcinoma and Gallbladder Cancer Studies
- Lung Cancer Research Studies
- Radiology practices and education
- Bone Tumor Diagnosis and Treatments
- Estrogen and related hormone effects
- Endometrial and Cervical Cancer Treatments
- Colorectal Cancer Screening and Detection
- Esophageal Cancer Research and Treatment
- Gastrointestinal Tumor Research and Treatment
- Adrenal and Paraganglionic Tumors
- Sarcoma Diagnosis and Treatment
- Neuroblastoma Research and Treatments
- Machine Learning in Healthcare
- Heat shock proteins research
- Gastrointestinal disorders and treatments
Emory University
2021-2025
Henry Ford Health System
2025
Henry Ford Hospital
2017-2024
Okayama University
2023
Chiba University
2023
Winship Cancer Institute
2019-2023
Emory Healthcare
2019-2023
Emory University Hospital
2022
The Barbara Ann Karmanos Cancer Institute
2019
Wayne State University
2015-2019
Pancreatic ductal adenocarcinoma (PDAC) is an aggressive tumor. Prognosis poor and survival low in patients diagnosed with this disease, a rate of ~12% at 5 years. Immunotherapy, including adoptive T cell transfer therapy, has not impacted the outcomes PDAC, due part to hostile tumor microenvironment (TME) which limits trafficking persistence. We posit that murine models serve as useful tools study fate therapy. Currently, genetically engineered mouse (GEMMs) for PDAC are considered...
Gastric cancer remains an unmet clinical problem in urgent need of newer and effective treatments. Here we show that the nuclear export protein, Exportin 1 (XPO1, chromosome region maintenance or CRM1), is a promising molecular target gastric cancer. We demonstrate significant overexpression XPO1 cohort histologically diverse patients with primary metastatic disease. RNA interference suppressed cell growth. Anti-tumor activity was observed specific inhibitor (SINE) compounds...
We conducted a phase Ib/II clinical trial to evaluate the safety, feasibility, and activity of combining pembrolizumab (anti-PD-1) with XL888 (Hsp90 inhibitor) in patients advanced colorectal cancer (CRC). hypothesized that this regimen would modulate soluble cellular immune mediators enhance outcomes. The employed 3 + open-label design, an expansion cohort at recommended II dose (RP2D) treatment-refractory, mismatch repair-proficient CRC patients. Comprehensive analyses plasma cytokines,...
Insufficient clinical information provided in radiology requests, coupled with the cumbersome nature of electronic health records (EHRs), poses significant challenges for radiologists extracting pertinent data and compiling detailed reports. Considering time involved navigating medical (EMR), an automated method to accurately compress text while maintaining key semantic could significantly enhance efficiency radiologists' workflow. The purpose this study is develop demonstrate tool note...
Endometrial carcinomas (ECs) are the most common gynecologic cancers in western world. The impact of androgen receptor (AR) on clinicopathologic parameters EC is not well studied. aim our study to assess role AR expression ECs and correlate its with estrogen (ER) progesterone (PR). A retrospective review 261 was conducted. H&E slides were reviewed analyzed. Immunohistochemical stains for AR, ER, PR performed a tissue microarray. hormonal evaluated data analyzed using Fisher exact test...
Alcohol use disorder is associated with increased mortality in septic patients. Murine studies demonstrate that ethanol/sepsis changes gut integrity. This study examined intestinal permeability after and investigated mechanisms responsible for alterations barrier function. Mice were randomized to drink either 20% ethanol or water 12 weeks then subjected sham laparotomy cecal ligation puncture (CLP). Intestinal was disproportionately ethanol/septic mice via the pore, leak, unrestricted...
Abstract Objectives Metastases are common in non-cirrhotic livers but considered unlikely the setting of cirrhosis. However, degree fibrosis cirrhosis may vary; thus metastases still access liver vasculature and present as a mass cirrhotic livers. This possibility affect pathologists’ diagnostic algorithms when faced with biopsy. Methods We hypothesized that can occur if fibrous remodeling is not severe or abnormal veno-arterial shunting exists to override an obstructed portal system....
Aim Barrett's esophagus (BE) is a predisposing factor of esophageal adenocarcinoma/gastroesophageal junction adenocarcinoma (ECA/GEJ Aca). BE patients are stratified and subsequently monitored according to the risk malignant progression by combination endoscopy biopsy. This study evaluate maspin expression patterns as early diagnostic markers malignancy in patients. Materials methods Immunohistochemistry (IHC) staining was performed on 62 archival core biopsies from 35 patients, including...
Objective: To determine if gaze deviation is a good predictor for large artery occlusions and interventional therapies Background: IV thrombolysis Mechanical thrombectomy are changing outcomes in acute stroke patients. Acute care strategies to reduce the time of intervention prehospital hospital setting can help the9 Time brain9 concept saving brain tissue. Stroke Guideline improve 9Time onset symptoms treatment9 has focused on using clinical scales, rapid triage, single call system,...
Abstract A 55-year-old woman admitted for hypertensive emergency and myocardial infarction reported weight gain, muscle weakness, easy bruising, recent-onset diabetes in the past 3 to 12 months. Urinary salivary cortisol adrenocorticotropin hormone (ACTH) levels were elevated. Pituitary imaging detected a macroadenoma. ACTH did not increase after corticotropin-releasing administration. Imaging revealed large pancreatic mass. Pathology indicated well-differentiated World Health Organization...
T regulatory (Treg) cells represent a unique subset of lymphocytes. Although they small fraction circulating (< 10%) are increasingly implicated in providing immuoregulatory function towards maintaining immune homeostasis. Treg dysregulation has been associated with autoimmune disease general, as well specific organ systems. This review provides an overview the characterization and health states emphasis their involvement gastrointestinal diseases. <b>ABBREVIATIONS:</b>DC – dendritic...
Abstract Pancreatic ductal adenocarcinoma (PDAC) is an aggressive tumor. Prognosis poor and survival low in patients diagnosed with this disease; ∼12% at 5 years. Immunotherapy, including adoptive T cell transfer therapy, has not impacted outcomes PDAC patients, due part to the hostile tumor microenvironment (TME) which limits trafficking persistence. We posit that murine models serve as useful tools study fate of therapy. Currently, genetically engineered mouse (GEMM) for are considered a...
<h3>Background</h3> Pancreatic ductal adenocarcinoma (PDAC) is an aggressive tumor with poor prognosis and low survival in patients (~12% at 5-years). Immunotherapy approaches, including adoptive T cell therapy, have not appreciably impacted PDAC patients. This outcome due part to the hostile microenvironment (TME) which limits trafficking persistence. We posit that murine models serve as useful tools study fate of adoptively transferred cells <i>in vivo</i>. Currently, genetically...
Abstract The high mortality rate associated with Gastric Cancer (GC) indicates the urgent need for actionable therapeutic targets. nuclear exporter protein exportin 1 (XPO1/CRM1) is exclusive of many tumor suppressor proteins (TPSs) and growth regulators. XPO1 often over-expressed in different malignancies leading to aberrant cytoplasmic localization TSPs subsequent inactivation. A detailed analysis on correlation inflammation-metaplasia-dysplasia-carcinoma sequence progression was performed...
Introduction: Neoadjuvant therapy is being increasingly employed to decrease tumor burden and improve outcomes in patients with pancreatic adenocarcinoma (PDAC). However, neoadjuvant creates challenges current size-based criteria used for pathologic staging as well regression grading. We aimed determine the utility of grading schemes PDAC receiving therapy. Materials Methods: 114 post-neoadjuvant pancreatectomy specimens were reviewed. Demographics, clinical information, standard parameters,...