A5028602612- Immune Cell Function and Interaction
- Autoimmune and Inflammatory Disorders Research
- Lymphoma Diagnosis and Treatment
- Renal and related cancers
- Ethics and Legal Issues in Pediatric Healthcare
- Brain Metastases and Treatment
- Fungal Infections and Studies
- Childhood Cancer Survivors' Quality of Life
- Parvovirus B19 Infection Studies
- Hematological disorders and diagnostics
- Neuroblastoma Research and Treatments
- Acute Lymphoblastic Leukemia research
- Neutropenia and Cancer Infections
- Glioma Diagnosis and Treatment
- CNS Lymphoma Diagnosis and Treatment
- Hemoglobinopathies and Related Disorders
- Hemophilia Treatment and Research
- Family and Disability Support Research
- Antifungal resistance and susceptibility
- RNA regulation and disease
- Bone Metabolism and Diseases
- Blood Coagulation and Thrombosis Mechanisms
- Autoimmune and Inflammatory Disorders
- Soft tissue tumor case studies
- Neurogenetic and Muscular Disorders Research
Erciyes University
2019-2025
Sağlık Bilimleri Üniversitesi
2025
Dokuz Eylül University
2021-2023
Antalya Eğitim ve Araştırma Hastanesi
2023
Istanbul University-Cerrahpaşa
2022
Bozok Universitesi
2021
Pediatrics and Genetics
2019
Febrile neutropenia (FN) is an important complication that causes high rates of morbidity and mortality in patients with malignancies. We aimed to investigate the etiology, epidemiological distribution its change over years, clinical courses, outcomes FN children acute leukemia.We retrospectively analyzed demographic data, characteristics, laboratory results, severe complications, pediatric between January 2010 December 2020.In 153 patients, a total 450 episodes (FNEs) occurred. Eighty-four...
Objective: B-cell Non-Hodgkin Lymphoma (B-NHL) is an aggressive malignancy in children requiring prompt multidisciplinary management. This retrospective cohort study aims to evaluate the clinical characteristics, treatment outcomes, and impact of rituximab (RTX) pediatric B-NHL patients. Methods: We retrospectively analyzed 62 patients treated at tertiary centers. Patient demographics, presentation, histopathological subtypes, disease stage, regimens, survival outcomes were assessed....
Aims: Infantile hemangioma (IH) is the most common benign vascular tumor in childhood. Diagnosis, treatment decisionmaking, and monitoring of are challenging. This study aims to investigate utilization platelet (PLT) indices as a marker follow-up IH treatment. Methods: The patients who were admitted followed up outpatient clinic Erciyes University Department Pediatric Hematology Oncology enrolled study. demographical data, results, PLT at certain time points analyzed retrospectively. PLT,...
Although familial hemophagocytic lymphohistiocytosis (FHL) generally manifest with a combination of unremitting fever, hepatosplenomegaly, and pancytopenia; unusual presentations should also be taken into account. Herein, we present 3 FHL cases 2 novel mutations different initial presentations. The first patient bearing homozygous truncation mutation in UNC13D (c.2650C>T.p.Gln884Ter) presented central nervous system involvement skin rash. responded to the HLH-2004 protocol, allogenic...
e14040 Background: To evaluate characteristics and treatment responses of patients with high grade gliomas (HGG) in our center Methods: Medical files malignant CNS tumors between 1987-2020 were analyzed retrospectively. There 44 HGG. Results: Diagnosis as follows: 21 pons glioma, 2 anaplastic astrocytoma, 11 ependimoma, 7 glioblastoma multiforme, 1 glioblastoma, gliomatosis cerebri. The median age at diagnosis was 6,5 yrs (7 – 17 yrs), M/F:25/19. Age distrubution: <5 12 patients, 5-10 18...
Invasive fungal infections are important causes of mortality and morbidity in immunodeficiencies, hematological malignancies, transplant recipients. There is scarce information the literature about diagnosis, treatment methods, management. Herein, a unique involvement site invasive infection caused by Aspergillus flavus nadir induction chemotherapy 13-year-old boy with diagnosis acute lymphoblastic leukemia presented. Despite prolonged intravenous antifungal therapy, patient exhibited an...
Hemophagocytic lymphohistiocytosis (HLH) is a life-threatening disease, with high mortality if left untreated. In addition, the disease has unique diagnostic challenges. Therefore, despite existing guidelines on management, current clinical practice data informative course and outcome. Herein, retrospective chart review study was conducted through collaboration of six centers, located in central southeastern Türkiye. The demographical data, laboratory results, treatment outcomes were...
With the rapid spread of coronavirus disease 2019 (COVID-19) around globe, concerns about management patients with malignancy have risen significantly. This study aimed to investigate possible impact COVID-19 pandemic and prevention policies on incidence etiology febrile neutropenia (FN) episodes in children acute leukemia. Children who had leukemia were diagnosed as FN a tertiary center from March 2018 2021 included study. grouped prepandemic postpandemic based date that was declared....
Hemophagocytic lymphohistiocytosis should be considered in patients with persistent fever, hepatosplenomegaly, pancytopenia. Hypercytokinemia originated from genetic disorder effecting the cellular defects of cytotoxic T and natural killer lymphocyte activity is underlying pathophysiology disorder. In this review we summarized recent advances management hemophagocytic lymphohistiocytosis.
Inherited hemolytic anemia is one of the most commonly seen anemias encountred in pediatric age, especially Türkiye, where consanguineous marriages are common. mainly includes hemoglobinopathies, erythrocyte membrane defects and enzyme defects. Hemolytic have a wide etiology clinical spectrum with acquired hereditary causes childhood. Always careful self family history review synthesis physical examination laboratory findings vital for differential diagnosis. Therefore, physicians should be...
Aim: Hemophilias are inherited bleeding disorders, in which the patients generally present with clinical complaints of hemarthrosis. Intracranial hemorrhage (ICH) is one severe types highest mortality and morbidity throughout childhood, as well a diagnosis hemophilia. Herein, single-center experience intracranial children hemophilia presented.
 Materials Methods: The files hospital records who were followed up by Pediatric Hematology Oncology Department Erciyes University between years...
Aims: The aim is to investigate the association of osteoprotegerin (OPG)/ soluble(s) receptor activator nuclear kappa B ligand (RANKL) with prognosis children acute lymphoblastic leukemia (ALL). Methods: Patients diagnosis ALL between years 2008-2010, were enrolled in study. Demographic characteristics and complete blood count findings, treatment responses, as well OPG sRANKL levels evaluated on admission at end induction treatment. Results: Mean serum 38,6 ±19,03 ng/ml 0,22±0,24 ng/ml,...
Wilms tumor (WT) is an embryonal of the kidneys. It associated with many oncogenic genetic aberrations and congenital anomalies. Owing to worldwide clinical research optimized patient care, curative therapy can be obtained in 90% diagnosed children WT. The decision treatment mainly depends on stage, age, histological type, markers. Except for WT; mesoblastic nephroma, clear cell sarcoma, malignant rhabdoid tumor, renal carcinoma constitute 5% kidney tumors. Herein, WT other tumors will emphasized.
Background. Congenital fibrinogen deficiency is one of the rare inherited coagulation disorders. complicated with a hematological malignancy can be life threatening. Case. We present four-year-old girl congenital acute lymphoblastic leukemia. Conclusion. This case aims to highlight therapeutic approaches for management afibrinogenemia patients
Pelger-Huet anomaly (PHA) is a benign hematological that characterized by impaired lobulation of neutrophils with coarse nuclear chromatin. Skeletal abnormalities may accompany this anomaly. Autosomal recessive deafness-4 (DFNB4) enlarged vestibular aqueduct (EVA) comprises phenotypic spectrum sensorineural hearing loss (SNHL). We report case SNHL, multiple skeletal anomalies including osteochondroma, developmental delay, and PHA. Molecular studies revealed heterozygous pathogenic variant in...
Aim: Hodgkin lymphoma (HL) constitutes 40% of childhood lymphomas and approximately 6% all cancers. It is tried to achieve cure with combined treatment modalities consisting chemotherapy, radiotherapy, monoclonal antibodies, new agents such as nivolumab. Radiotherapy-related infertility, secondary cancer, thyroid dysfunction, cardiovascular diseases, pulmonary fibrosis, local skin reactions can be seen in the pediatric age group a long life expectancy. In this article, patients diagnosed...
To evaluate characteristics and treatment responses of patients with high grade gliomas (HGG) in our center. Medical files malignant CNS tumors between 1987-2020 were analyzed retrospectively. There 44 HGG. Diagnosis as follows: 21 pons glioma, 2 anaplastic astrocytoma, 11 ependimoma, 7 glioblastoma multiforme, 1 glioblastoma, gliomatosis cerebri. The median age at diagnosis was 6,5 yrs (7 – 17 yrs), M/F:25/19. Age distribution: <5 12 patients, 5-10 18 10-18 14 patients. most frequent...