A5078484659- Advanced Drug Delivery Systems
- Advancements in Transdermal Drug Delivery
- Ocular Surface and Contact Lens
- Pharmacological Effects of Natural Compounds
- Lipid Membrane Structure and Behavior
- Hydrogels: synthesis, properties, applications
- Lysosomal Storage Disorders Research
- Advanced Chemical Sensor Technologies
- Neurological Disorders and Treatments
- Acne and Rosacea Treatments and Effects
- Drug Solubulity and Delivery Systems
- Protein Interaction Studies and Fluorescence Analysis
- Bee Products Chemical Analysis
- Autophagy in Disease and Therapy
- Flavonoids in Medical Research
- Nanoparticle-Based Drug Delivery
- Cellular transport and secretion
- Inflammatory mediators and NSAID effects
University of Szeged
2018-2023
Eötvös Loránd University
2020
The aim of this study was to perform a preformulation dexamethasone (DXM)-loaded nanostructured lipid carriers (NLCs) for ocular use. Lipid screening applied find the most suitable solid and liquid lipids surfactant NLC formulation. visual observation proved with XRD measurements establishment soluble state DXM. Thermoanalytical indicated that relevant depression crystallinity index could be ensured when using 7:3 lipid:oil ratio. In order optimize composition, 23 full factorial experimental...
Thiolated poly(aspartic acid) is known as a good mucoadhesive polymer in aqueous ophthalmic formulations. In this paper, cyclodextrin-modified thiolated was synthesized for the incorporation of prednisolone, lipophilic drug, an situ gellable solution. This combines advantages cyclodextrins and polymers. The formation cyclodextrin-drug complex gels analyzed by X-ray powder diffraction. ocular applicability characterized means physicochemical, rheological drug diffusion tests. It established...
Generally, topically applied eye drops have low bioavailability due to short residence time and penetration of the drug. The aim present study was incorporate dexamethasone (DXM) into nano lipid carriers (NLC), which contain mucoadhesive polymer, in order increase A 23 factorial experimental design applied, three factors were DXM, emulsifier concentrations. samples analyzed for particle size, zeta potential, polydispersity index, Span value. significant identified. biocompatibility...
The present study aimed at developing a potential in situ gellable dexamethasone (DXM) eye drop. Poly(aspartic acid) (PASP) derivatives were synthesized with dual functionality to improve the solubility of DXM, and achieve gelation. First, amine-modified β-cyclodextrin (CD) was attached polysuccinimide (PSI), second, thiol functionalities added by reaction cysteamine succinimide rings. Finally, PSI hydrolysed corresponding PASP get water-soluble polymers. Phase-solubility studies confirmed...
The present study aimed at developing a potential in situ gellable dexamethasone (DXM) eye drop. Poly(aspartic acid) (PASP) derivatives were synthesized with dual functionality to improve the solubility of DXM, and achieve gelation. First, amine-modified β-cyclodextrin (CD) was attached polysuccinimide (PSI), second, thiol functionalities added by reaction cysteamine succinimide rings. Finally, PSI hydrolysed corresponding PASP get water-soluble polymers. Phase-solubility studies confirmed...
Abstract Macroautophagy is a lysosomal-dependent degradational pathway of eukaryotic cells, during which toxic, unnecessary, and damaged intracellular components are broken down. Autophagic activity declines with age, this change could contribute to the accumulation damage at advanced ages, causing cells lose their functionality vitality. This be particularly problematic in post-mitotic include neurons, mass destruction leads different neurodegenerative diseases. We aim discover new...
Today, the development of an effective ophthalmic drug delivery system is a major challenge.The most commonly used preparations are eye drops, which have low bioavailability due to complex structure and elimination mechanism [1].Nanostructured lipid carrier (NLC) second-generation solid nanoparticles that contain matrix mixed liquid lipids.These systems ideal for incorporation drugs with water solubility, such as corticosteroids [2].The aim study was incorporate dexamethasone (DXM) into...