A5040240289- Lipid Membrane Structure and Behavior
- Photoreceptor and optogenetics research
- Advanced biosensing and bioanalysis techniques
- RNA Interference and Gene Delivery
- Porphyrin and Phthalocyanine Chemistry
- Hemoglobin structure and function
- Photochromic and Fluorescence Chemistry
- Water Quality Monitoring and Analysis
- Force Microscopy Techniques and Applications
- Cellular transport and secretion
- Spectroscopy and Chemometric Analyses
- Supramolecular Chemistry and Complexes
- Molecular Biology Techniques and Applications
- Heat shock proteins research
- RNA Research and Splicing
- Advanced Polymer Synthesis and Characterization
- Plasmonic and Surface Plasmon Research
- Spectroscopy Techniques in Biomedical and Chemical Research
- Cellular Mechanics and Interactions
- Mitochondrial Function and Pathology
Max Planck Institute of Biochemistry
2021-2025
Abstract Mitochondria play critical roles in regulating cell fate, with dysfunction correlating the development of multiple diseases, emphasizing need for engineered nanomedicines that cross biological barriers. Said often target fluctuating mitochondrial properties and/or present inefficient/insufficient cytosolic delivery (resulting poor overall activity), while many require complex synthetic procedures involving targeting residues (hindering clinical translation). The...
Abstract Membranes are the key structures to separate and spatially organize cellular systems. Their rich dynamics transformations during cell cycle orchestrated by specific membrane‐targeted molecular machineries, many of which operate through energy dissipation. Likewise, man‐made light‐activated rotary motors have previously shown drastic effects on systems, but their physical roles within lipid membranes remain largely unexplored. Here, impact well‐defined biological is systematically...
Lipid membranes are essential for cellular function, acting as barriers and platforms major biochemical activities. The integration of photoisomerizable units into lipid structures allows tunable membrane properties, offering insights membrane-related processes. In this study, we present the first molecular-motor-conjugated phospholipid system. synthesis two phosphatidylcholine derivatives is reported, where one acyl chain replaced with a light-responsive molecular rotary motor moiety. We...
Abstract Self‐assembly of biological molecules and structures is a fundamental property life. Whereas most functions are based on self‐assembled proteins protein complexes, the self‐assembly lipids important for spatial organization heterogeneous cellular reaction environments to catalyze cooperative interactions on/with membranes. Lipid domains or “rafts”, which known selectively recruit proteins, play an functional role in sorting trafficking membrane components between subcellular...
Abstract A key challenge for bottom-up synthetic biology is engineering a minimal module self-division of cells. Actin-based cytokinetic rings are considered promising structure to produce the forces required controlled excision cell-like compartments such as giant unilamellar vesicles (GUVs). Despite prior demonstrations actin ring targeting GUV membranes and myosin-induced constriction, large-scale vesicle deformation has been precluded due lacking spatial control these contractile...
Nanotechnology often exploits DNA origami nanostructures assembled into even larger superstructures up to micrometer sizes with nanometer shape precision. However, large-scale assembly of such structures is very time-consuming. Here, we investigated the efficiency superstructure on surfaces using indirect cross-linking through low-complexity connector strands binding staple strand extensions, instead scaffold loops. Using single-molecule imaging techniques, including fluorescence microscopy...
In biology, membranes are the key structures to separate and spatially organize cellular reaction systems. Their rich dynamics transformations during cell cycle orchestrated by specific membrane-targeted molecular machineries many of which operate through energy dissipation. Likewise, man-made rotary motors powered light have previously shown drastic effects on systems, but their physical roles within lipid remain largely unexplored. Here we systematically investigate impact well-defined...
In biology, membranes are the key structures to separate and spatially organize cellular reaction systems. Their rich dynamics transformations during cell cycle orchestrated by specific membrane-targeted molecular machineries many of which operate through energy dissipation. Likewise, man-made rotary motors powered light have previously shown drastic effects on systems, but their physical roles within lipid remain largely unexplored. Here we systematically investigate impact well-defined...
Abstract One of the challenges bottom-up synthetic biology is engineering a minimal module for self-division cells. To produce contractile forces required controlled excision cell-like compartments such as giant unilamellar vesicles (GUVs), reconstituted cytokinetic rings made actin are considered to be among most promising structures potential division machinery. Although targeting GUV membranes and their myosin-induced constriction have been previously demonstrated, large-scale vesicle...